A network of Gα i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF

G protein–coupled receptors (GPCRs) that couple to the Gα family of G proteins are key regulators of cell and tissue physiology. Our previous work has revealed new roles for Gα in regulating the migration of neutrophils and fibrosarcoma cells downstream of activated chemoattractant receptors. Here,...

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Veröffentlicht in:	Science signaling 2022-01, Vol.15 (717), p.eabi9869-eabi9869
Hauptverfasser:	Chandan, Naincy R, Abraham, Saji, SenGupta, Shuvasree, Parent, Carole A, Smrcka, Alan V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Phenomena Chemotaxis Fibrosarcoma GTP-Binding Protein alpha Subunits, Gi-Go - genetics GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Humans Labeling Leukocytes (neutrophilic) Mass spectrometry Mass spectroscopy Neutrophils Proteins Proteomics Receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Rho Guanine Nucleotide Exchange Factors - metabolism RhoA protein Signal Transduction - physiology
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