Hypocretins (orexins): The ultimate translational neuropeptides

The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively in the lateral hypothalamus. They act on two specific receptors that are widely distributed across the brain and involved in a myriad of neurophysiological functions that include sleep, arousal, feeding, rewar...

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Veröffentlicht in:	Journal of internal medicine 2022-05, Vol.291 (5), p.533-556
Hauptverfasser:	Jacobson, Laura H., Hoyer, Daniel, Lecea, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Arousal Cataplexy Circadian rhythms Circuits Cognition daridorexant Drug delivery Drug development drug discovery and clinical development Drugs Humans hypocretin/orexin Hypothalamus Hypothalamus (lateral) Insomnia Intracellular Signaling Peptides and Proteins lemborexant Narcolepsy Narcolepsy - drug therapy Nervous system Neurodegenerative diseases Neuropeptides Neuropeptides - physiology Orexins Receptors Reinforcement Sleep Sleep and wakefulness Sleep disorders Sleep Initiation and Maintenance Disorders suvorexant Therapeutic applications Therapeutic targets Wakefulness
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