HMCES safeguards genome integrity and long-term self-renewal of hematopoietic stem cells during stress responses

Hematopoietic stress drives quiescent hematopoietic stem cells (HSCs) to proliferate, generating reactive oxygen species (ROS) and oxidative DNA damage including abasic sites. Such a coupling between rapid DNA replication and a burst of abasic site formation during HSC stress responses, however, pre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2022-04, Vol.36 (4), p.1123-1131
Hauptverfasser:	Pan, Yinghao, Zuo, Hongna, Wen, Fei, Huang, Fei, Zhu, Yezhang, Cao, Lanrui, Sha, Qian-Qian, Li, Yang, Zhang, Huiying, Shi, Miao, Liang, Chengzhen, Huang, Jun, Zou, Lin, Fan, Heng-Yu, Ju, Zhenyu, Wang, Hu, Shen, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38 38/71 42/89 45 45/41 45/91 631/136/232 631/532/1542 631/67/1990/283 64/60 96/100 Animals Bone marrow Cancer Research Cell self-renewal Cellular stress response Critical Care Medicine Damage Deoxyribonucleic acid DNA DNA - metabolism DNA biosynthesis DNA Damage DNA repair DNA Replication DNA-Binding Proteins - genetics Genomes Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Humans Intensive Internal Medicine Irradiation Leukemia Lymphatic leukemia Medicine Medicine & Public Health Mice Oncology Radiation Reactive oxygen species Repair Replication Single-stranded DNA Stem cell transplantation Stem cells Transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!