Evidence of requirement for homologous‐mediated DNA repair during Ambystoma mexicanum limb regeneration

Background Limb regeneration in the axolotl is achieved by epimorphosis, thus depending on the blastema formation, a mass of progenitor cells capable of proliferating and differentiating to recover all lost structures functionally. During regeneration, the blastema cells accelerate the cell cycle an...

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Veröffentlicht in:	Developmental dynamics 2022-06, Vol.251 (6), p.1035-1053
Hauptverfasser:	García‐Lepe, Ulises Omar, Torres‐Dimas, Esteban, Espinal‐Centeno, Annie, Cruz‐Ramírez, Alfredo, Bermúdez‐Cruz, Rosa María
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambystoma mexicanum - physiology Amputation Animals axolotl B02 Cell cycle Cell differentiation Cells (biology) Damage Deoxyribonucleic acid DNA DNA Damage DNA Repair Extremities - physiology Genomes Homologous recombination Homologous recombination repair Homology mirin Mre11 MRE11 protein Progenitor cells Rad51 Regeneration Regeneration - physiology Repair Senescence Stem cells
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