Macrophage-Mimic Hollow Mesoporous Fe-Based Nanocatalysts for Self-Amplified Chemodynamic Therapy and Metastasis Inhibition via Tumor Microenvironment Remodeling

Fe-based nanomaterials with Fenton reaction activity are promising for tumor-specific chemodynamic therapy (CDT). However, most of the nanomaterials suffer from low catalytic efficiency due to its insufficient active site exposure and the relatively high tumor intracellular pH, which greatly impede...

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Veröffentlicht in:	ACS applied materials & interfaces 2022-02, Vol.14 (4), p.5053-5065
Hauptverfasser:	Zuo, Wenbao, Chen, Weibin, Liu, Jinxue, Huang, Shuying, Chen, Luping, Liu, Qingna, Liu, Nian, Jin, Quanyi, Li, Yang, Wang, Peiyuan, Zhu, Xuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Biological and Medical Applications of Materials and Interfaces Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - therapeutic use Carbonic Anhydrase IX - antagonists & inhibitors Catalysis Cell Line, Tumor Cell Membrane - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Liberation Female Ferric Compounds - chemistry Humans Hydroxyl Radical - metabolism Macrophages - chemistry Metal Nanoparticles - chemistry Mice Mice, Inbred BALB C Neoplasm Metastasis - prevention & control Neoplasms - drug therapy Porosity Precision Medicine Sulfonamides - chemistry Sulfonamides - therapeutic use Tumor Microenvironment - drug effects
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