The role of T-LAK cell-originated protein kinase in targeted cancer therapy
Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exce...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2022-03, Vol.477 (3), p.759-769 |
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| container_title | Molecular and cellular biochemistry |
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| creator | Zhang, Lu Wang, Fei Yi, Huijun Ermakova, Svetlana P. Malyarenko, Olesya S. Mo, Jianmei Huang, Yingze Duan, Qiuhong Xiao, Juanjuan Zhu, Feng |
| description | Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exceptions of testicular germ cells and some fetal tissues. It can promote cancer cell proliferation and migration and is also related to drug resistance. Therefore, TOPK is considered a good therapeutic target. Moreover, a number of studies have shown that targeting TOPK can inhibit the proliferation of cancer cells and promote their apoptosis. Here, we discussed the biological functions of TOPK in cancer and summarized its tumor-related signaling network and known TOPK inhibitors. Finally, the role of TOPK in targeted cancer therapy was concluded, and future research directions for TOPK were assessed. |
| doi_str_mv | 10.1007/s11010-021-04329-5 |
| format | Article |
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TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exceptions of testicular germ cells and some fetal tissues. It can promote cancer cell proliferation and migration and is also related to drug resistance. Therefore, TOPK is considered a good therapeutic target. Moreover, a number of studies have shown that targeting TOPK can inhibit the proliferation of cancer cells and promote their apoptosis. Here, we discussed the biological functions of TOPK in cancer and summarized its tumor-related signaling network and known TOPK inhibitors. Finally, the role of TOPK in targeted cancer therapy was concluded, and future research directions for TOPK were assessed.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-021-04329-5</identifier><identifier>PMID: 35037144</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antimitotic agents ; Antineoplastic agents ; Apoptosis ; Apoptosis - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Cancer ; Cancer therapies ; Cardiology ; Care and treatment ; Cell migration ; Cell proliferation ; Cell Proliferation - drug effects ; Development and progression ; Drug Delivery Systems ; Drug resistance ; Fetuses ; Germ cells ; Health aspects ; Humans ; Killer cells ; Kinases ; Life Sciences ; MAP kinase ; Medical Biochemistry ; Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors ; Mitogen-Activated Protein Kinase Kinases - metabolism ; Neoplasm Proteins - antagonists & inhibitors ; Neoplasm Proteins - metabolism ; Neoplasms - drug therapy ; Neoplasms - enzymology ; Oncology ; Pantoprazole ; Protein kinase ; Protein Kinase Inhibitors - therapeutic use ; Protein kinases ; Proteins ; Side effects ; Signal Transduction - drug effects ; Targeted cancer therapy ; Therapeutic targets ; Therapy ; Tumors</subject><ispartof>Molecular and cellular biochemistry, 2022-03, Vol.477 (3), p.759-769</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b48dadcbaa45902fc372cb0a4a0eb5acb8c192c35a1db29b2c3ead9f252c1e323</citedby><cites>FETCH-LOGICAL-c442t-b48dadcbaa45902fc372cb0a4a0eb5acb8c192c35a1db29b2c3ead9f252c1e323</cites><orcidid>0000-0001-9852-0925</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-021-04329-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-021-04329-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35037144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Yi, Huijun</creatorcontrib><creatorcontrib>Ermakova, Svetlana P.</creatorcontrib><creatorcontrib>Malyarenko, Olesya S.</creatorcontrib><creatorcontrib>Mo, Jianmei</creatorcontrib><creatorcontrib>Huang, Yingze</creatorcontrib><creatorcontrib>Duan, Qiuhong</creatorcontrib><creatorcontrib>Xiao, Juanjuan</creatorcontrib><creatorcontrib>Zhu, Feng</creatorcontrib><title>The role of T-LAK cell-originated protein kinase in targeted cancer therapy</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exceptions of testicular germ cells and some fetal tissues. It can promote cancer cell proliferation and migration and is also related to drug resistance. Therefore, TOPK is considered a good therapeutic target. Moreover, a number of studies have shown that targeting TOPK can inhibit the proliferation of cancer cells and promote their apoptosis. Here, we discussed the biological functions of TOPK in cancer and summarized its tumor-related signaling network and known TOPK inhibitors. Finally, the role of TOPK in targeted cancer therapy was concluded, and future research directions for TOPK were assessed.</description><subject>Animals</subject><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cardiology</subject><subject>Care and treatment</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Development and progression</subject><subject>Drug Delivery Systems</subject><subject>Drug resistance</subject><subject>Fetuses</subject><subject>Germ cells</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Killer cells</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>MAP kinase</subject><subject>Medical Biochemistry</subject><subject>Mitogen-Activated Protein Kinase Kinases - 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Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lu</au><au>Wang, Fei</au><au>Yi, Huijun</au><au>Ermakova, Svetlana P.</au><au>Malyarenko, Olesya S.</au><au>Mo, Jianmei</au><au>Huang, Yingze</au><au>Duan, Qiuhong</au><au>Xiao, Juanjuan</au><au>Zhu, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of T-LAK cell-originated protein kinase in targeted cancer therapy</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>477</volume><issue>3</issue><spage>759</spage><epage>769</epage><pages>759-769</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exceptions of testicular germ cells and some fetal tissues. It can promote cancer cell proliferation and migration and is also related to drug resistance. Therefore, TOPK is considered a good therapeutic target. Moreover, a number of studies have shown that targeting TOPK can inhibit the proliferation of cancer cells and promote their apoptosis. Here, we discussed the biological functions of TOPK in cancer and summarized its tumor-related signaling network and known TOPK inhibitors. Finally, the role of TOPK in targeted cancer therapy was concluded, and future research directions for TOPK were assessed.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35037144</pmid><doi>10.1007/s11010-021-04329-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9852-0925</orcidid></addata></record> |
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| subjects | Animals Antimitotic agents Antineoplastic agents Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Cancer Cancer therapies Cardiology Care and treatment Cell migration Cell proliferation Cell Proliferation - drug effects Development and progression Drug Delivery Systems Drug resistance Fetuses Germ cells Health aspects Humans Killer cells Kinases Life Sciences MAP kinase Medical Biochemistry Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - enzymology Oncology Pantoprazole Protein kinase Protein Kinase Inhibitors - therapeutic use Protein kinases Proteins Side effects Signal Transduction - drug effects Targeted cancer therapy Therapeutic targets Therapy Tumors |
| title | The role of T-LAK cell-originated protein kinase in targeted cancer therapy |
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