Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort
Aims In‐situ follicular neoplasia (ISFN) is a histologically recognizable neoplastic proliferation of follicular lymphoma (FL)‐like B cells confined to the germinal centres. While some ISFNs are associated with overt FL, others are incidentally identified as isolated or pure forms in individuals wit...
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| Veröffentlicht in: | Histopathology 2022-04, Vol.80 (5), p.820-826 |
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| creator | Oishi, Naoki Segawa, Takahiro Miyake, Kunio Mochizuki, Kunio Kondo, Tetsuo |
| description | Aims
In‐situ follicular neoplasia (ISFN) is a histologically recognizable neoplastic proliferation of follicular lymphoma (FL)‐like B cells confined to the germinal centres. While some ISFNs are associated with overt FL, others are incidentally identified as isolated or pure forms in individuals without evidence of overt FL. The prevalence of incidentally found isolated ISFN is approximately 3% in Europe; however, no screening study has been conducted in Asia. To investigate the incidence and clinicopathological characteristics of ISFNs in the Japanese population, we conducted histopathological screening of the lymph nodes (LNs) resected for solid tumours or inflammatory conditions.
Methods and results
We screened for ISFN in 5700 LNs from 340 individuals using immunohistochemistry for BCL2 and identified seven ISFNs, with an incidence of 2.1%. The median age of the individuals with ISFN was 67 years, none of whom developed overt FL, with a median follow‐up of 59 months. Next‐generation sequencing was performed in five ISFNs, and 10 variants in seven FL‐associated genes were identified. The identified variants included HIST1H1E (n = 2), ARID1A (n = 2), KMT2D (n = 1), CARD11 (n = 1), BCL7A (n = 1), CREBBP (n = 1) and TNFRSF14 (n = 1).
Conclusions
The incidence of isolated ISFN in the Japanese population is not significantly different from that in Europe, presumably reflecting the recent increase in FL in Japan. These incidentally found ISFNs have a low potential to transform into overt FL. Although mutations of FL‐associated genes are already present in ISFNs, further molecular studies are needed to identify driver genes leading to the transformation of ISFN to overt FL.
By immunohistochemical screening of 5700 LNs from 340 individuals, isolated in‐situ follicular neoplasia (ISFN) was identified in 2.1% of Japanese population. Next‐generation sequencing identified variants involving HIST1H1E, ARID1A, KMT2D, CARD11, BCL7A, CREBBPand TNFRSF14in ISFNs. |
| doi_str_mv | 10.1111/his.14617 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2620779983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2620779983</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4197-1c1bf674099e473f40cce631968d88773b3ef1509b3936c202623aa8c78bc45b3</originalsourceid><addsrcrecordid>eNp10cFu1DAQBmALgejScuAFkCUuRWpaO07suDdUQbuoUg9tz5Ezmey68trBTqj2xgNw4Bl5krps4YDUuczlm18j_YS84-yY5zlZ23TMK8nVC7LgQtZFWdf6JVkwwXTBuFR75E1Kd4xxJcryNdkTNRMN12JBfi492B494BEFZ72FMJppHVxYWTCODmimOWKixvd0hR4nC4mGgVr_-8evZKeZDsE5C7MzkXoMozPJmlNqKITNGHGNPtnvSBNERG_9iqZp7rf5PpOvZjQeE2a7DnE6IK8G4xK-fdr75PbL55uzi-Ly6nx59umygIprVXDg3SBVxbTGSomhYgAoBdey6ZtGKdEJHHjNdCe0kFCyUpbCmAZU00FVd2KfHO5yxxi-zZimdmMToHP5mTCnNnumlNaNyPTDf_QuzNHn77KqSl7WQqqsPu4UxJBSxKEdo92YuG05ax8ranNF7Z-Ksn3_lDh3G-z_yb-dZHCyA_fW4fb5pPZieb2LfAA4hZzj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642125367</pqid></control><display><type>article</type><title>Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Oishi, Naoki ; Segawa, Takahiro ; Miyake, Kunio ; Mochizuki, Kunio ; Kondo, Tetsuo</creator><creatorcontrib>Oishi, Naoki ; Segawa, Takahiro ; Miyake, Kunio ; Mochizuki, Kunio ; Kondo, Tetsuo</creatorcontrib><description>Aims
In‐situ follicular neoplasia (ISFN) is a histologically recognizable neoplastic proliferation of follicular lymphoma (FL)‐like B cells confined to the germinal centres. While some ISFNs are associated with overt FL, others are incidentally identified as isolated or pure forms in individuals without evidence of overt FL. The prevalence of incidentally found isolated ISFN is approximately 3% in Europe; however, no screening study has been conducted in Asia. To investigate the incidence and clinicopathological characteristics of ISFNs in the Japanese population, we conducted histopathological screening of the lymph nodes (LNs) resected for solid tumours or inflammatory conditions.
Methods and results
We screened for ISFN in 5700 LNs from 340 individuals using immunohistochemistry for BCL2 and identified seven ISFNs, with an incidence of 2.1%. The median age of the individuals with ISFN was 67 years, none of whom developed overt FL, with a median follow‐up of 59 months. Next‐generation sequencing was performed in five ISFNs, and 10 variants in seven FL‐associated genes were identified. The identified variants included HIST1H1E (n = 2), ARID1A (n = 2), KMT2D (n = 1), CARD11 (n = 1), BCL7A (n = 1), CREBBP (n = 1) and TNFRSF14 (n = 1).
Conclusions
The incidence of isolated ISFN in the Japanese population is not significantly different from that in Europe, presumably reflecting the recent increase in FL in Japan. These incidentally found ISFNs have a low potential to transform into overt FL. Although mutations of FL‐associated genes are already present in ISFNs, further molecular studies are needed to identify driver genes leading to the transformation of ISFN to overt FL.
By immunohistochemical screening of 5700 LNs from 340 individuals, isolated in‐situ follicular neoplasia (ISFN) was identified in 2.1% of Japanese population. Next‐generation sequencing identified variants involving HIST1H1E, ARID1A, KMT2D, CARD11, BCL7A, CREBBPand TNFRSF14in ISFNs.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.14617</identifier><identifier>PMID: 35038193</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; BCL2 ; Carcinoma in Situ - epidemiology ; Carcinoma in Situ - genetics ; Carcinoma in Situ - pathology ; Cell proliferation ; CREBBP ; Early Detection of Cancer ; Female ; follicular lymphoma ; Follow-Up Studies ; Germinal centers ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Incidence ; Inflammation ; in‐situ follicular B‐cell neoplasm ; in‐situ follicular neoplasia ; Japan - epidemiology ; Lymph nodes ; Lymph Nodes - pathology ; Lymphocytes B ; Lymphoma ; Lymphoma, Follicular - epidemiology ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - pathology ; Male ; Middle Aged ; Prevalence ; Solid tumors</subject><ispartof>Histopathology, 2022-04, Vol.80 (5), p.820-826</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4197-1c1bf674099e473f40cce631968d88773b3ef1509b3936c202623aa8c78bc45b3</citedby><cites>FETCH-LOGICAL-c4197-1c1bf674099e473f40cce631968d88773b3ef1509b3936c202623aa8c78bc45b3</cites><orcidid>0000-0001-9196-2229 ; 0000-0003-2268-0302 ; 0000-0001-9577-0320 ; 0000-0002-9365-1093 ; 0000-0002-3111-708X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.14617$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.14617$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35038193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oishi, Naoki</creatorcontrib><creatorcontrib>Segawa, Takahiro</creatorcontrib><creatorcontrib>Miyake, Kunio</creatorcontrib><creatorcontrib>Mochizuki, Kunio</creatorcontrib><creatorcontrib>Kondo, Tetsuo</creatorcontrib><title>Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
In‐situ follicular neoplasia (ISFN) is a histologically recognizable neoplastic proliferation of follicular lymphoma (FL)‐like B cells confined to the germinal centres. While some ISFNs are associated with overt FL, others are incidentally identified as isolated or pure forms in individuals without evidence of overt FL. The prevalence of incidentally found isolated ISFN is approximately 3% in Europe; however, no screening study has been conducted in Asia. To investigate the incidence and clinicopathological characteristics of ISFNs in the Japanese population, we conducted histopathological screening of the lymph nodes (LNs) resected for solid tumours or inflammatory conditions.
Methods and results
We screened for ISFN in 5700 LNs from 340 individuals using immunohistochemistry for BCL2 and identified seven ISFNs, with an incidence of 2.1%. The median age of the individuals with ISFN was 67 years, none of whom developed overt FL, with a median follow‐up of 59 months. Next‐generation sequencing was performed in five ISFNs, and 10 variants in seven FL‐associated genes were identified. The identified variants included HIST1H1E (n = 2), ARID1A (n = 2), KMT2D (n = 1), CARD11 (n = 1), BCL7A (n = 1), CREBBP (n = 1) and TNFRSF14 (n = 1).
Conclusions
The incidence of isolated ISFN in the Japanese population is not significantly different from that in Europe, presumably reflecting the recent increase in FL in Japan. These incidentally found ISFNs have a low potential to transform into overt FL. Although mutations of FL‐associated genes are already present in ISFNs, further molecular studies are needed to identify driver genes leading to the transformation of ISFN to overt FL.
By immunohistochemical screening of 5700 LNs from 340 individuals, isolated in‐situ follicular neoplasia (ISFN) was identified in 2.1% of Japanese population. Next‐generation sequencing identified variants involving HIST1H1E, ARID1A, KMT2D, CARD11, BCL7A, CREBBPand TNFRSF14in ISFNs.</description><subject>Aged</subject><subject>BCL2</subject><subject>Carcinoma in Situ - epidemiology</subject><subject>Carcinoma in Situ - genetics</subject><subject>Carcinoma in Situ - pathology</subject><subject>Cell proliferation</subject><subject>CREBBP</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>follicular lymphoma</subject><subject>Follow-Up Studies</subject><subject>Germinal centers</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Incidence</subject><subject>Inflammation</subject><subject>in‐situ follicular B‐cell neoplasm</subject><subject>in‐situ follicular neoplasia</subject><subject>Japan - epidemiology</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphocytes B</subject><subject>Lymphoma</subject><subject>Lymphoma, Follicular - epidemiology</subject><subject>Lymphoma, Follicular - genetics</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Solid tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFu1DAQBmALgejScuAFkCUuRWpaO07suDdUQbuoUg9tz5Ezmey68trBTqj2xgNw4Bl5krps4YDUuczlm18j_YS84-yY5zlZ23TMK8nVC7LgQtZFWdf6JVkwwXTBuFR75E1Kd4xxJcryNdkTNRMN12JBfi492B494BEFZ72FMJppHVxYWTCODmimOWKixvd0hR4nC4mGgVr_-8evZKeZDsE5C7MzkXoMozPJmlNqKITNGHGNPtnvSBNERG_9iqZp7rf5PpOvZjQeE2a7DnE6IK8G4xK-fdr75PbL55uzi-Ly6nx59umygIprVXDg3SBVxbTGSomhYgAoBdey6ZtGKdEJHHjNdCe0kFCyUpbCmAZU00FVd2KfHO5yxxi-zZimdmMToHP5mTCnNnumlNaNyPTDf_QuzNHn77KqSl7WQqqsPu4UxJBSxKEdo92YuG05ax8ranNF7Z-Ksn3_lDh3G-z_yb-dZHCyA_fW4fb5pPZieb2LfAA4hZzj</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Oishi, Naoki</creator><creator>Segawa, Takahiro</creator><creator>Miyake, Kunio</creator><creator>Mochizuki, Kunio</creator><creator>Kondo, Tetsuo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9196-2229</orcidid><orcidid>https://orcid.org/0000-0003-2268-0302</orcidid><orcidid>https://orcid.org/0000-0001-9577-0320</orcidid><orcidid>https://orcid.org/0000-0002-9365-1093</orcidid><orcidid>https://orcid.org/0000-0002-3111-708X</orcidid></search><sort><creationdate>202204</creationdate><title>Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort</title><author>Oishi, Naoki ; Segawa, Takahiro ; Miyake, Kunio ; Mochizuki, Kunio ; Kondo, Tetsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4197-1c1bf674099e473f40cce631968d88773b3ef1509b3936c202623aa8c78bc45b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>BCL2</topic><topic>Carcinoma in Situ - epidemiology</topic><topic>Carcinoma in Situ - genetics</topic><topic>Carcinoma in Situ - pathology</topic><topic>Cell proliferation</topic><topic>CREBBP</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>follicular lymphoma</topic><topic>Follow-Up Studies</topic><topic>Germinal centers</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Incidence</topic><topic>Inflammation</topic><topic>in‐situ follicular B‐cell neoplasm</topic><topic>in‐situ follicular neoplasia</topic><topic>Japan - epidemiology</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphocytes B</topic><topic>Lymphoma</topic><topic>Lymphoma, Follicular - epidemiology</topic><topic>Lymphoma, Follicular - genetics</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Solid tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oishi, Naoki</creatorcontrib><creatorcontrib>Segawa, Takahiro</creatorcontrib><creatorcontrib>Miyake, Kunio</creatorcontrib><creatorcontrib>Mochizuki, Kunio</creatorcontrib><creatorcontrib>Kondo, Tetsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oishi, Naoki</au><au>Segawa, Takahiro</au><au>Miyake, Kunio</au><au>Mochizuki, Kunio</au><au>Kondo, Tetsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2022-04</date><risdate>2022</risdate><volume>80</volume><issue>5</issue><spage>820</spage><epage>826</epage><pages>820-826</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims
In‐situ follicular neoplasia (ISFN) is a histologically recognizable neoplastic proliferation of follicular lymphoma (FL)‐like B cells confined to the germinal centres. While some ISFNs are associated with overt FL, others are incidentally identified as isolated or pure forms in individuals without evidence of overt FL. The prevalence of incidentally found isolated ISFN is approximately 3% in Europe; however, no screening study has been conducted in Asia. To investigate the incidence and clinicopathological characteristics of ISFNs in the Japanese population, we conducted histopathological screening of the lymph nodes (LNs) resected for solid tumours or inflammatory conditions.
Methods and results
We screened for ISFN in 5700 LNs from 340 individuals using immunohistochemistry for BCL2 and identified seven ISFNs, with an incidence of 2.1%. The median age of the individuals with ISFN was 67 years, none of whom developed overt FL, with a median follow‐up of 59 months. Next‐generation sequencing was performed in five ISFNs, and 10 variants in seven FL‐associated genes were identified. The identified variants included HIST1H1E (n = 2), ARID1A (n = 2), KMT2D (n = 1), CARD11 (n = 1), BCL7A (n = 1), CREBBP (n = 1) and TNFRSF14 (n = 1).
Conclusions
The incidence of isolated ISFN in the Japanese population is not significantly different from that in Europe, presumably reflecting the recent increase in FL in Japan. These incidentally found ISFNs have a low potential to transform into overt FL. Although mutations of FL‐associated genes are already present in ISFNs, further molecular studies are needed to identify driver genes leading to the transformation of ISFN to overt FL.
By immunohistochemical screening of 5700 LNs from 340 individuals, isolated in‐situ follicular neoplasia (ISFN) was identified in 2.1% of Japanese population. Next‐generation sequencing identified variants involving HIST1H1E, ARID1A, KMT2D, CARD11, BCL7A, CREBBPand TNFRSF14in ISFNs.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35038193</pmid><doi>10.1111/his.14617</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9196-2229</orcidid><orcidid>https://orcid.org/0000-0003-2268-0302</orcidid><orcidid>https://orcid.org/0000-0001-9577-0320</orcidid><orcidid>https://orcid.org/0000-0002-9365-1093</orcidid><orcidid>https://orcid.org/0000-0002-3111-708X</orcidid></addata></record> |
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| subjects | Aged BCL2 Carcinoma in Situ - epidemiology Carcinoma in Situ - genetics Carcinoma in Situ - pathology Cell proliferation CREBBP Early Detection of Cancer Female follicular lymphoma Follow-Up Studies Germinal centers High-Throughput Nucleotide Sequencing Humans Immunohistochemistry Incidence Inflammation in‐situ follicular B‐cell neoplasm in‐situ follicular neoplasia Japan - epidemiology Lymph nodes Lymph Nodes - pathology Lymphocytes B Lymphoma Lymphoma, Follicular - epidemiology Lymphoma, Follicular - genetics Lymphoma, Follicular - pathology Male Middle Aged Prevalence Solid tumors |
| title | Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort |
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