Research advances in the role and pharmaceuticals of ATP-binding cassette transporters in autoimmune diseases
Autoimmune diseases are caused by the immune response of the body to its antigens, resulting in tissue damage. The pathogenesis of these diseases has not yet been elucidated. Most autoimmune diseases cannot be cured by effective drugs. The treatment strategy is to relieve the symptoms of the disease...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2022-04, Vol.477 (4), p.1075-1091 |
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| creator | Yu, Jun Chen, Hao Xu, Jiangmei Zhou, Peng |
| description | Autoimmune diseases are caused by the immune response of the body to its antigens, resulting in tissue damage. The pathogenesis of these diseases has not yet been elucidated. Most autoimmune diseases cannot be cured by effective drugs. The treatment strategy is to relieve the symptoms of the disease and balance the body’s autoimmune function. The abnormal expression of ATP-binding cassette (ABC) transporters is directly related to the pathogenesis of autoimmune diseases and drug therapy resistance, which poses a great challenge for the drug therapy of autoimmune diseases. Therefore, this paper reviews the interplay between ABC transporters and the pathogenesis of autoimmune diseases to provide research progress and new ideas for the development of drugs in autoimmune diseases. |
| doi_str_mv | 10.1007/s11010-022-04354-y |
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The pathogenesis of these diseases has not yet been elucidated. Most autoimmune diseases cannot be cured by effective drugs. The treatment strategy is to relieve the symptoms of the disease and balance the body’s autoimmune function. The abnormal expression of ATP-binding cassette (ABC) transporters is directly related to the pathogenesis of autoimmune diseases and drug therapy resistance, which poses a great challenge for the drug therapy of autoimmune diseases. Therefore, this paper reviews the interplay between ABC transporters and the pathogenesis of autoimmune diseases to provide research progress and new ideas for the development of drugs in autoimmune diseases.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-022-04354-y</identifier><identifier>PMID: 35034257</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antigens ; ATP ; ATP-Binding Cassette Transporters - antagonists & inhibitors ; ATP-Binding Cassette Transporters - immunology ; ATP-binding protein ; Autoimmune diseases ; Autoimmune Diseases - drug therapy ; Autoimmune Diseases - immunology ; Binding ; Biochemistry ; Biomedical and Life Sciences ; Cardiology ; Chemotherapy ; Development and progression ; Drug Development ; Drug therapy ; Drugs ; Humans ; Immune response ; Immunosuppressive agents ; Life Sciences ; Medical Biochemistry ; Medical research ; Medicine, Experimental ; Oncology ; Pathogenesis ; Signs and symptoms</subject><ispartof>Molecular and cellular biochemistry, 2022-04, Vol.477 (4), p.1075-1091</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. 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The pathogenesis of these diseases has not yet been elucidated. Most autoimmune diseases cannot be cured by effective drugs. The treatment strategy is to relieve the symptoms of the disease and balance the body’s autoimmune function. The abnormal expression of ATP-binding cassette (ABC) transporters is directly related to the pathogenesis of autoimmune diseases and drug therapy resistance, which poses a great challenge for the drug therapy of autoimmune diseases. Therefore, this paper reviews the interplay between ABC transporters and the pathogenesis of autoimmune diseases to provide research progress and new ideas for the development of drugs in autoimmune diseases.</description><subject>Antigens</subject><subject>ATP</subject><subject>ATP-Binding Cassette Transporters - antagonists & inhibitors</subject><subject>ATP-Binding Cassette Transporters - immunology</subject><subject>ATP-binding protein</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - immunology</subject><subject>Binding</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiology</subject><subject>Chemotherapy</subject><subject>Development and progression</subject><subject>Drug Development</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunosuppressive agents</subject><subject>Life Sciences</subject><subject>Medical Biochemistry</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Oncology</subject><subject>Pathogenesis</subject><subject>Signs and symptoms</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUuLFDEUhYMoTjv6B1xIwI2bjHlVpWrZDL5gQJFxHVLJTXeGqqRNUkL_ezPTo4MikkXg5jsn996D0EtGLxil6m1hjDJKKOeEStFJcnyENqxTgsiRjY_RhgpKycCUOkPPSrmhjaaMPUVnoqNC8k5t0PIVCphs99i4HyZaKDhEXPeAc5oBm-jwYW_yYiysNVgzF5w83l5_IVOILsQdtqYUqBVwzSaWQ8oV8p2JWWsKy7JGwC60TwqU5-iJbxbw4v4-R9_ev7u-_EiuPn_4dLm9IlZKXslgRil70Ts2cjVJwZz1sjdUTl456YbeU9UKfpqkYnZgUgkupRrs0HEQthPn6M3J95DT9xVK1UsoFubZREhr0bznVCnKO9nQ13-hN2nNsXXXKKEGxtpqH6idmUGH6FOb1t6a6m0_9pKJttBGXfyDasfBEmyK4EOr_yHgJ4HNqZQMXh9yWEw-akb1bcb6lLFuGeu7jPWxiV7dd7xOC7jfkl-hNkCcgNKe4g7yw0j_sf0JYmywTg</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Yu, Jun</creator><creator>Chen, Hao</creator><creator>Xu, Jiangmei</creator><creator>Zhou, Peng</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1375-1394</orcidid></search><sort><creationdate>20220401</creationdate><title>Research advances in the role and pharmaceuticals of ATP-binding cassette transporters in autoimmune diseases</title><author>Yu, Jun ; Chen, Hao ; Xu, Jiangmei ; Zhou, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-8a944636d1927b431dcf46a04bf7d4d86f07f46fbb471c8147324478c852e3c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antigens</topic><topic>ATP</topic><topic>ATP-Binding Cassette Transporters - 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| subjects | Antigens ATP ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - immunology ATP-binding protein Autoimmune diseases Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Binding Biochemistry Biomedical and Life Sciences Cardiology Chemotherapy Development and progression Drug Development Drug therapy Drugs Humans Immune response Immunosuppressive agents Life Sciences Medical Biochemistry Medical research Medicine, Experimental Oncology Pathogenesis Signs and symptoms |
| title | Research advances in the role and pharmaceuticals of ATP-binding cassette transporters in autoimmune diseases |
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