Trans-Arterial Radioembolization with Yttrium-90 of Unresectable and Systemic Chemotherapy Resistant Hepatoblastoma in Three Toddlers
The aim of this short communication was to report the results of transarterial radioembolization (TARE) with Yttrium-90 (Y90) loaded resin microspheres in three toddlers with unresectable and systemic chemotherapy-resistant HB hepatoblastoma (HB). Six TARE procedures were performed on the patients....
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2022-03, Vol.45 (3), p.344-348 |
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| creator | Balli, Huseyin Tugsan Aikimbaev, Kairgeldy Guney, Isa Burak Piskin, Ferhat Can Yagci-Kupeli, Begul Kupeli, Serhan Kanmaz, Turan |
| description | The aim of this short communication was to report the results of transarterial radioembolization (TARE) with Yttrium-90 (Y90) loaded resin microspheres in three toddlers with unresectable and systemic chemotherapy-resistant HB hepatoblastoma (HB). Six TARE procedures were performed on the patients. The dose required for treatment was calculated using partition model. Administered doses of Y90 were 1.369, 0.851, and 1.147 GBq. Complete radiological response in two patients and partial response enabling liver resection in one patient were achieved. Neither life-threatening nor minor complications developed after the treatment. These results demonstrates that HB is a radiosensitive neoplasm, and TARE-Y90 can be used as the primary, neoadjuvant and palliative treatment method in patients with unresectable and systemic chemotherapy-resistant HBs. However, studies with higher number of patients and long-term results are required. |
| doi_str_mv | 10.1007/s00270-021-03026-6 |
| format | Article |
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Six TARE procedures were performed on the patients. The dose required for treatment was calculated using partition model. Administered doses of Y90 were 1.369, 0.851, and 1.147 GBq. Complete radiological response in two patients and partial response enabling liver resection in one patient were achieved. Neither life-threatening nor minor complications developed after the treatment. These results demonstrates that HB is a radiosensitive neoplasm, and TARE-Y90 can be used as the primary, neoadjuvant and palliative treatment method in patients with unresectable and systemic chemotherapy-resistant HBs. However, studies with higher number of patients and long-term results are required.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-021-03026-6</identifier><identifier>PMID: 35034139</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Carcinoma, Hepatocellular - therapy ; Cardiology ; Chemotherapy ; Child, Preschool ; Complications ; Embolization, Therapeutic - methods ; Hepatoblastoma - diagnostic imaging ; Hepatoblastoma - therapy ; Humans ; Imaging ; Interventional Oncology ; Liver Neoplasms - drug therapy ; Medicine ; Medicine & Public Health ; Microspheres ; Nuclear Medicine ; Patients ; Radiology ; Short Communication ; Ultrasound ; Yttrium ; Yttrium isotopes ; Yttrium Radioisotopes - therapeutic use</subject><ispartof>Cardiovascular and interventional radiology, 2022-03, Vol.45 (3), p.344-348</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021</rights><rights>2021. 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Six TARE procedures were performed on the patients. The dose required for treatment was calculated using partition model. Administered doses of Y90 were 1.369, 0.851, and 1.147 GBq. Complete radiological response in two patients and partial response enabling liver resection in one patient were achieved. Neither life-threatening nor minor complications developed after the treatment. These results demonstrates that HB is a radiosensitive neoplasm, and TARE-Y90 can be used as the primary, neoadjuvant and palliative treatment method in patients with unresectable and systemic chemotherapy-resistant HBs. 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| ispartof | Cardiovascular and interventional radiology, 2022-03, Vol.45 (3), p.344-348 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Carcinoma, Hepatocellular - therapy Cardiology Chemotherapy Child, Preschool Complications Embolization, Therapeutic - methods Hepatoblastoma - diagnostic imaging Hepatoblastoma - therapy Humans Imaging Interventional Oncology Liver Neoplasms - drug therapy Medicine Medicine & Public Health Microspheres Nuclear Medicine Patients Radiology Short Communication Ultrasound Yttrium Yttrium isotopes Yttrium Radioisotopes - therapeutic use |
| title | Trans-Arterial Radioembolization with Yttrium-90 of Unresectable and Systemic Chemotherapy Resistant Hepatoblastoma in Three Toddlers |
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