Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model
Herbal medicines have gained tremendous surge of interest in recent years. M. nigra leaves are a rich source of phenolics which are well-known for their antioxidant property. Morus nigra popularly known as black mulberry is considered to be the most significant species of genus Morus. This study was...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2021-11, Vol.34 (6), p.2167-2171 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Zehra, Tabbassum Sarfaraz, Sana Ikram, Rahela |
| description | Herbal medicines have gained tremendous surge of interest in recent years. M. nigra leaves are a rich source of phenolics which are well-known for their antioxidant property. Morus nigra popularly known as black mulberry is considered to be the most significant species of genus Morus. This study was designed to evaluate its activity on seizure model in different doses. Five groups were made comprising of n=10 animals in each group respectively. Group I was on distilled water, Group II was administered with reference drug diazepam and Group III, IV and V were on 125mg/kg, 250mg/kg and 500mg/kg dose of Morus nigra for 15 days prior to experiment. On day 16th all animals were administered with strychnine after 30 minutes of respective treatments and three parameters were recorded i.e. duration, frequency and onset of seizures. M. nigra treatment showed significant seizure protection as noted by delayed latency of seizures (P |
| doi_str_mv | 10.36721/PJPS.2021.34.6.REG.2167-2171.1 |
| format | Article |
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M. nigra leaves are a rich source of phenolics which are well-known for their antioxidant property. Morus nigra popularly known as black mulberry is considered to be the most significant species of genus Morus. This study was designed to evaluate its activity on seizure model in different doses. Five groups were made comprising of n=10 animals in each group respectively. Group I was on distilled water, Group II was administered with reference drug diazepam and Group III, IV and V were on 125mg/kg, 250mg/kg and 500mg/kg dose of Morus nigra for 15 days prior to experiment. On day 16th all animals were administered with strychnine after 30 minutes of respective treatments and three parameters were recorded i.e. duration, frequency and onset of seizures. M. nigra treatment showed significant seizure protection as noted by delayed latency of seizures (P<0.05), decrease in frequency and jerk's duration (P<0.05) in comparison to control and reference standard. Most significant (P<0.05) anticonvulsant effects were observed with 500mg/kg dose. Anticonvulsant activity of M. nigra could be due to potentiation of both Gabaergic and glycinergic activities. Antiepileptic potential of extract could also be amplified due to its antioxidant activity. This could serve as a non-pharmacological treatment for seizure management.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2021.34.6.REG.2167-2171.1</identifier><identifier>PMID: 35034877</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Animals ; Anticonvulsants ; Anticonvulsants - isolation & purification ; Anticonvulsants - pharmacology ; Brain - drug effects ; Brain - physiopathology ; Care and treatment ; Chemical properties ; Disease Models, Animal ; Dose-response relationship (Biochemistry) ; Fruit ; Health aspects ; Male ; Materia medica, Vegetable ; Medicine, Botanic ; Medicine, Herbal ; Mice ; Morus - chemistry ; Mulberry ; Pharmacology, Experimental ; Plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Seizures (Medicine) ; Seizures - chemically induced ; Seizures - physiopathology ; Seizures - prevention & control ; Strychnine ; Time Factors</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2021-11, Vol.34 (6), p.2167-2171</ispartof><rights>COPYRIGHT 2021 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-e5dce927865d496780295557f59762d4c8ca43410344c904a458bb2c83690cff3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35034877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zehra, Tabbassum</creatorcontrib><creatorcontrib>Sarfaraz, Sana</creatorcontrib><creatorcontrib>Ikram, Rahela</creatorcontrib><title>Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Herbal medicines have gained tremendous surge of interest in recent years. M. nigra leaves are a rich source of phenolics which are well-known for their antioxidant property. Morus nigra popularly known as black mulberry is considered to be the most significant species of genus Morus. This study was designed to evaluate its activity on seizure model in different doses. Five groups were made comprising of n=10 animals in each group respectively. Group I was on distilled water, Group II was administered with reference drug diazepam and Group III, IV and V were on 125mg/kg, 250mg/kg and 500mg/kg dose of Morus nigra for 15 days prior to experiment. On day 16th all animals were administered with strychnine after 30 minutes of respective treatments and three parameters were recorded i.e. duration, frequency and onset of seizures. M. nigra treatment showed significant seizure protection as noted by delayed latency of seizures (P<0.05), decrease in frequency and jerk's duration (P<0.05) in comparison to control and reference standard. Most significant (P<0.05) anticonvulsant effects were observed with 500mg/kg dose. Anticonvulsant activity of M. nigra could be due to potentiation of both Gabaergic and glycinergic activities. Antiepileptic potential of extract could also be amplified due to its antioxidant activity. This could serve as a non-pharmacological treatment for seizure management.</description><subject>Animals</subject><subject>Anticonvulsants</subject><subject>Anticonvulsants - isolation & purification</subject><subject>Anticonvulsants - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Disease Models, Animal</subject><subject>Dose-response relationship (Biochemistry)</subject><subject>Fruit</subject><subject>Health aspects</subject><subject>Male</subject><subject>Materia medica, Vegetable</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Mice</subject><subject>Morus - chemistry</subject><subject>Mulberry</subject><subject>Pharmacology, Experimental</subject><subject>Plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Seizures (Medicine)</subject><subject>Seizures - chemically induced</subject><subject>Seizures - physiopathology</subject><subject>Seizures - prevention & control</subject><subject>Strychnine</subject><subject>Time Factors</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLxDAYRbNQHF9_QQIudNOad5qljOOojCg-QNyUTPJVI206Nu3A-OutqKvLhcPhchE6oSTnSjN6dn9z_5gzwmjORa7yh9k8Z1TpjFFNc7qFdimhNFOEvkzQXkofhChhjNlBEy4JF4XWu-j1ok2APawgeog9trEPro3roU72p7o-rEO_wW2Fb9tuSDiGt87iEHHqu417jyHC2PzgwOME4WvoIOGm9VAfoO3K1gkO_3IfPV_OnqZX2eJufj09X2SOE9pnIL0Dw3ShpBdG6YIwI6XUlTRaMS9c4azggo6LhTNEWCGL5ZK5gitDXFXxfXT661117ecAqS-bkBzUtY3QDqlkihGtNBdmRI9_0TdbQxli1faddT94ea4KY7Rmshipoz_hsGzAl6suNLbblP-v8W--XG-W</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Zehra, Tabbassum</creator><creator>Sarfaraz, Sana</creator><creator>Ikram, Rahela</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model</title><author>Zehra, Tabbassum ; Sarfaraz, Sana ; Ikram, Rahela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-e5dce927865d496780295557f59762d4c8ca43410344c904a458bb2c83690cff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anticonvulsants</topic><topic>Anticonvulsants - isolation & purification</topic><topic>Anticonvulsants - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Care and treatment</topic><topic>Chemical properties</topic><topic>Disease Models, Animal</topic><topic>Dose-response relationship (Biochemistry)</topic><topic>Fruit</topic><topic>Health aspects</topic><topic>Male</topic><topic>Materia medica, Vegetable</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Mice</topic><topic>Morus - chemistry</topic><topic>Mulberry</topic><topic>Pharmacology, Experimental</topic><topic>Plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Seizures (Medicine)</topic><topic>Seizures - chemically induced</topic><topic>Seizures - physiopathology</topic><topic>Seizures - prevention & control</topic><topic>Strychnine</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zehra, Tabbassum</creatorcontrib><creatorcontrib>Sarfaraz, Sana</creatorcontrib><creatorcontrib>Ikram, Rahela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zehra, Tabbassum</au><au>Sarfaraz, Sana</au><au>Ikram, Rahela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2021-11</date><risdate>2021</risdate><volume>34</volume><issue>6</issue><spage>2167</spage><epage>2171</epage><pages>2167-2171</pages><issn>1011-601X</issn><abstract>Herbal medicines have gained tremendous surge of interest in recent years. M. nigra leaves are a rich source of phenolics which are well-known for their antioxidant property. Morus nigra popularly known as black mulberry is considered to be the most significant species of genus Morus. This study was designed to evaluate its activity on seizure model in different doses. Five groups were made comprising of n=10 animals in each group respectively. Group I was on distilled water, Group II was administered with reference drug diazepam and Group III, IV and V were on 125mg/kg, 250mg/kg and 500mg/kg dose of Morus nigra for 15 days prior to experiment. On day 16th all animals were administered with strychnine after 30 minutes of respective treatments and three parameters were recorded i.e. duration, frequency and onset of seizures. M. nigra treatment showed significant seizure protection as noted by delayed latency of seizures (P<0.05), decrease in frequency and jerk's duration (P<0.05) in comparison to control and reference standard. Most significant (P<0.05) anticonvulsant effects were observed with 500mg/kg dose. Anticonvulsant activity of M. nigra could be due to potentiation of both Gabaergic and glycinergic activities. Antiepileptic potential of extract could also be amplified due to its antioxidant activity. This could serve as a non-pharmacological treatment for seizure management.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>35034877</pmid><doi>10.36721/PJPS.2021.34.6.REG.2167-2171.1</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Anticonvulsants Anticonvulsants - isolation & purification Anticonvulsants - pharmacology Brain - drug effects Brain - physiopathology Care and treatment Chemical properties Disease Models, Animal Dose-response relationship (Biochemistry) Fruit Health aspects Male Materia medica, Vegetable Medicine, Botanic Medicine, Herbal Mice Morus - chemistry Mulberry Pharmacology, Experimental Plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Seizures (Medicine) Seizures - chemically induced Seizures - physiopathology Seizures - prevention & control Strychnine Time Factors |
| title | Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model |
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