Factors associated with high cardiovascular risk in psoriatic arthritis and non-psoriatic spondyloarthritis
To identify the association between traditional cardiovascular risk factors, diseases related factors, body composition and adipokines with high cardiovascular risk (HCVR) in psoriatic arthritis and non-psoriatic spondyloarthritis. This was a cross-sectional study involving age and BMI matched adult...
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| Veröffentlicht in: | Rheumatology international 2022-02, Vol.42 (2), p.251-260 |
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| description | To identify the association between traditional cardiovascular risk factors, diseases related factors, body composition and adipokines with high cardiovascular risk (HCVR) in psoriatic arthritis and non-psoriatic spondyloarthritis. This was a cross-sectional study involving age and BMI matched adults with psoriatic arthritis (PsA) (
n
= 56) and non-psoriatic spondyloarthritis (nPsA–SpA) (
n
= 58). Body composition using whole-body dual energy X-ray absorptiometry, adipokines and disease characteristics along with cardiovascular risk scoring QRISK3 and carotid intimal medial thickness (CIMT) was collected. Individuals with a QRISK3 ≥ 10% or CIMT of ≥ 75 percentile of the general population were categorised as HCVR. Predictors of HCVR were determined by logistic regression. HCVR was detected in 39 (34.2%) of the patients. After adjusting for all the factors, sarcopenia (aOR-15.83; 95% CI 1.16–215.48;
p
= 0.038) and presence of any traditional CV comorbidity (aOR: 18.97; 95% CI 1.63–221.29;
p
= 0.019) were associated with HCVR. nPsA–SpA had a 97% lesser chance of having HCVR as compared to PsA. The ROC curve analysis for the multiple logistic regression model which estimated the AUC as 0.787 (95% CI 0.701–0.874) and a
P
value |
| doi_str_mv | 10.1007/s00296-021-05064-2 |
| format | Article |
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n
= 56) and non-psoriatic spondyloarthritis (nPsA–SpA) (
n
= 58). Body composition using whole-body dual energy X-ray absorptiometry, adipokines and disease characteristics along with cardiovascular risk scoring QRISK3 and carotid intimal medial thickness (CIMT) was collected. Individuals with a QRISK3 ≥ 10% or CIMT of ≥ 75 percentile of the general population were categorised as HCVR. Predictors of HCVR were determined by logistic regression. HCVR was detected in 39 (34.2%) of the patients. After adjusting for all the factors, sarcopenia (aOR-15.83; 95% CI 1.16–215.48;
p
= 0.038) and presence of any traditional CV comorbidity (aOR: 18.97; 95% CI 1.63–221.29;
p
= 0.019) were associated with HCVR. nPsA–SpA had a 97% lesser chance of having HCVR as compared to PsA. The ROC curve analysis for the multiple logistic regression model which estimated the AUC as 0.787 (95% CI 0.701–0.874) and a
P
value < 0.001. Adipokine levels correlated well with body composition, but not with HCVR. PsA has a higher CV risk and the mechanisms for the same are poorly understood. Sarcopenia is an important determinant of HCVR and may be due to ectopic adipose tissue deposition in skeletal muscles. Focused physical therapy to prevent sarcopenia, optimum treatment of traditional CV risk factors and adequate disease control may help in preventing atherosclerosis in SpA.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-021-05064-2</identifier><identifier>PMID: 35031846</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adipokines - blood ; Adult ; Arthritis, Psoriatic - complications ; Arthritis, Psoriatic - physiopathology ; Atherosclerosis ; Body composition ; Body Mass Index ; Cardiovascular Diseases - etiology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Heart Disease Risk Factors ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Observational Research ; Psoriatic arthritis ; Rheumatology ; Sarcopenia ; Spondylarthritis - complications ; Spondylarthritis - physiopathology</subject><ispartof>Rheumatology international, 2022-02, Vol.42 (2), p.251-260</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a8ee1fb212bdf7c93a1d11407b9ae247e11e1110030a8a2e691483167fe4824f3</citedby><cites>FETCH-LOGICAL-c375t-a8ee1fb212bdf7c93a1d11407b9ae247e11e1110030a8a2e691483167fe4824f3</cites><orcidid>0000-0003-4519-0226 ; 0000-0001-7168-0689 ; 0000-0003-3224-1151 ; 0000-0003-1518-6031 ; 0000-0002-3643-3989</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-021-05064-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-021-05064-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35031846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kavadichanda, Chengappa</creatorcontrib><creatorcontrib>Shanoj, K. C.</creatorcontrib><creatorcontrib>Ganapathy, Sachit</creatorcontrib><creatorcontrib>Shah, Sanket I.</creatorcontrib><creatorcontrib>Ananthakrishnan, Ramesh</creatorcontrib><creatorcontrib>Sahoo, Jayprakash</creatorcontrib><creatorcontrib>Negi, Vir Singh</creatorcontrib><title>Factors associated with high cardiovascular risk in psoriatic arthritis and non-psoriatic spondyloarthritis</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>To identify the association between traditional cardiovascular risk factors, diseases related factors, body composition and adipokines with high cardiovascular risk (HCVR) in psoriatic arthritis and non-psoriatic spondyloarthritis. This was a cross-sectional study involving age and BMI matched adults with psoriatic arthritis (PsA) (
n
= 56) and non-psoriatic spondyloarthritis (nPsA–SpA) (
n
= 58). Body composition using whole-body dual energy X-ray absorptiometry, adipokines and disease characteristics along with cardiovascular risk scoring QRISK3 and carotid intimal medial thickness (CIMT) was collected. Individuals with a QRISK3 ≥ 10% or CIMT of ≥ 75 percentile of the general population were categorised as HCVR. Predictors of HCVR were determined by logistic regression. HCVR was detected in 39 (34.2%) of the patients. After adjusting for all the factors, sarcopenia (aOR-15.83; 95% CI 1.16–215.48;
p
= 0.038) and presence of any traditional CV comorbidity (aOR: 18.97; 95% CI 1.63–221.29;
p
= 0.019) were associated with HCVR. nPsA–SpA had a 97% lesser chance of having HCVR as compared to PsA. The ROC curve analysis for the multiple logistic regression model which estimated the AUC as 0.787 (95% CI 0.701–0.874) and a
P
value < 0.001. Adipokine levels correlated well with body composition, but not with HCVR. PsA has a higher CV risk and the mechanisms for the same are poorly understood. Sarcopenia is an important determinant of HCVR and may be due to ectopic adipose tissue deposition in skeletal muscles. Focused physical therapy to prevent sarcopenia, optimum treatment of traditional CV risk factors and adequate disease control may help in preventing atherosclerosis in SpA.</description><subject>Adipokines - blood</subject><subject>Adult</subject><subject>Arthritis, Psoriatic - complications</subject><subject>Arthritis, Psoriatic - physiopathology</subject><subject>Atherosclerosis</subject><subject>Body composition</subject><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Observational Research</subject><subject>Psoriatic arthritis</subject><subject>Rheumatology</subject><subject>Sarcopenia</subject><subject>Spondylarthritis - complications</subject><subject>Spondylarthritis - physiopathology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1qGzEUhUVpqJ2kL9BFEXSTjdJ7pbE0XhaTPwhk00B2QtZoYsXjkas705K3jxynDnRREBLifudInMPYF4RzBDDfCUDOtQCJAmagKyE_sClWygjU8PCRTQGNFHXZJuyY6AnKXWv4xCZqBgrrSk_Z-tL5IWXijij56IbQ8D9xWPFVfFxx73IT029Hfuxc5jnSmseebynlgkbPXR5WOQ6x6PuG96kX7zPapr557tKBOWVHresofH47T9j95cXPxbW4vbu6Wfy4FV6Z2SBcHQK2S4ly2bTGz5XDBrECs5y7ICsTEMsqCShwtZNBz7GqFWrThqqWVatO2Nned5vTrzHQYDeRfOg614c0kpVaAtS10bOCfvsHfUpj7svvdpTSapdZoeSe8jkR5dDabY4bl58tgt1VYfdV2FKFfa3CyiL6-mY9LjehOUj-Zl8AtQeojPrHkN_f_o_tC-GdlUU</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Kavadichanda, Chengappa</creator><creator>Shanoj, K. C.</creator><creator>Ganapathy, Sachit</creator><creator>Shah, Sanket I.</creator><creator>Ananthakrishnan, Ramesh</creator><creator>Sahoo, Jayprakash</creator><creator>Negi, Vir Singh</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4519-0226</orcidid><orcidid>https://orcid.org/0000-0001-7168-0689</orcidid><orcidid>https://orcid.org/0000-0003-3224-1151</orcidid><orcidid>https://orcid.org/0000-0003-1518-6031</orcidid><orcidid>https://orcid.org/0000-0002-3643-3989</orcidid></search><sort><creationdate>20220201</creationdate><title>Factors associated with high cardiovascular risk in psoriatic arthritis and non-psoriatic spondyloarthritis</title><author>Kavadichanda, Chengappa ; Shanoj, K. 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C.</creatorcontrib><creatorcontrib>Ganapathy, Sachit</creatorcontrib><creatorcontrib>Shah, Sanket I.</creatorcontrib><creatorcontrib>Ananthakrishnan, Ramesh</creatorcontrib><creatorcontrib>Sahoo, Jayprakash</creatorcontrib><creatorcontrib>Negi, Vir Singh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kavadichanda, Chengappa</au><au>Shanoj, K. C.</au><au>Ganapathy, Sachit</au><au>Shah, Sanket I.</au><au>Ananthakrishnan, Ramesh</au><au>Sahoo, Jayprakash</au><au>Negi, Vir Singh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with high cardiovascular risk in psoriatic arthritis and non-psoriatic spondyloarthritis</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>42</volume><issue>2</issue><spage>251</spage><epage>260</epage><pages>251-260</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>To identify the association between traditional cardiovascular risk factors, diseases related factors, body composition and adipokines with high cardiovascular risk (HCVR) in psoriatic arthritis and non-psoriatic spondyloarthritis. This was a cross-sectional study involving age and BMI matched adults with psoriatic arthritis (PsA) (
n
= 56) and non-psoriatic spondyloarthritis (nPsA–SpA) (
n
= 58). Body composition using whole-body dual energy X-ray absorptiometry, adipokines and disease characteristics along with cardiovascular risk scoring QRISK3 and carotid intimal medial thickness (CIMT) was collected. Individuals with a QRISK3 ≥ 10% or CIMT of ≥ 75 percentile of the general population were categorised as HCVR. Predictors of HCVR were determined by logistic regression. HCVR was detected in 39 (34.2%) of the patients. After adjusting for all the factors, sarcopenia (aOR-15.83; 95% CI 1.16–215.48;
p
= 0.038) and presence of any traditional CV comorbidity (aOR: 18.97; 95% CI 1.63–221.29;
p
= 0.019) were associated with HCVR. nPsA–SpA had a 97% lesser chance of having HCVR as compared to PsA. The ROC curve analysis for the multiple logistic regression model which estimated the AUC as 0.787 (95% CI 0.701–0.874) and a
P
value < 0.001. Adipokine levels correlated well with body composition, but not with HCVR. PsA has a higher CV risk and the mechanisms for the same are poorly understood. Sarcopenia is an important determinant of HCVR and may be due to ectopic adipose tissue deposition in skeletal muscles. Focused physical therapy to prevent sarcopenia, optimum treatment of traditional CV risk factors and adequate disease control may help in preventing atherosclerosis in SpA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35031846</pmid><doi>10.1007/s00296-021-05064-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4519-0226</orcidid><orcidid>https://orcid.org/0000-0001-7168-0689</orcidid><orcidid>https://orcid.org/0000-0003-3224-1151</orcidid><orcidid>https://orcid.org/0000-0003-1518-6031</orcidid><orcidid>https://orcid.org/0000-0002-3643-3989</orcidid></addata></record> |
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| ispartof | Rheumatology international, 2022-02, Vol.42 (2), p.251-260 |
| issn | 0172-8172 1437-160X |
| language | eng |
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| subjects | Adipokines - blood Adult Arthritis, Psoriatic - complications Arthritis, Psoriatic - physiopathology Atherosclerosis Body composition Body Mass Index Cardiovascular Diseases - etiology Carotid Intima-Media Thickness Cross-Sectional Studies Female Heart Disease Risk Factors Humans Male Medicine Medicine & Public Health Middle Aged Observational Research Psoriatic arthritis Rheumatology Sarcopenia Spondylarthritis - complications Spondylarthritis - physiopathology |
| title | Factors associated with high cardiovascular risk in psoriatic arthritis and non-psoriatic spondyloarthritis |
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