High prevalence of middle cerebral artery calcification is associated with cardiovascular mortality in hemodialyzed patients: an overlooked part of arterial tree?
Purpose We have analyzed markers of accelerated atherosclerosis like large artery stiffness, ankle-brachial index, carotid and vertebral duplex ultrasonography and their possible associations with the incidence of intracranial calcifications, clinical course of hemodialyzed patients, and cardiovascu...
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| Veröffentlicht in: | International urology and nephrology 2022-08, Vol.54 (8), p.1995-2004 |
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| container_title | International urology and nephrology |
| container_volume | 54 |
| creator | Premužić, Vedran Gardijan, Danilo Herega, Tomislav Perkov, Dražen Jelaković, Bojan |
| description | Purpose
We have analyzed markers of accelerated atherosclerosis like large artery stiffness, ankle-brachial index, carotid and vertebral duplex ultrasonography and their possible associations with the incidence of intracranial calcifications, clinical course of hemodialyzed patients, and cardiovascular mortality.
Methods
A computed tomographic scan of the head was performed for any neurological indication on 100 hemodialyzed patients. Eleven intracranial arteries were analyzed for calcification score, while internal carotid arteries and vertebral arteries were excluded in cerebral artery calcification score. As a control group for assessing intracranial calcifications, we have analyzed computed tomographic scans from diabetic patients who had an acute stroke.
Results
Deceased patients had significantly higher values of augmentation index and pulse wave velocity, lower ankle-brachial index, and higher internal carotid arteries peak systolic value than survived patients. Deceased patients had significantly higher number of calcified middle cerebral arteries as well as significantly higher intracranial artery calcification score and cerebral artery calcification score. Hemodialyzed patients had significantly higher both intracranial and cerebral artery calcification scores than diabetic control group. Age and calcified middle cerebral arteries had increased HR of 1.08 and 1.36 for cardiovascular mortality.
Conclusion
This study showed that large artery stiffness and not the presence of peripheral arterial disease or carotid artery stenosis have the prognostic role of middle cerebral arteries’ calcifications and cardiovascular mortality in hemodialyzed patients. The presence of middle cerebral arteries’ calcifications diagnosed by a non-invasive method should be considered a marker of middle-sized conduit arteries atherosclerosis, subclinical brain damage, and future fatal cardiovascular events. |
| doi_str_mv | 10.1007/s11255-021-03092-2 |
| format | Article |
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We have analyzed markers of accelerated atherosclerosis like large artery stiffness, ankle-brachial index, carotid and vertebral duplex ultrasonography and their possible associations with the incidence of intracranial calcifications, clinical course of hemodialyzed patients, and cardiovascular mortality.
Methods
A computed tomographic scan of the head was performed for any neurological indication on 100 hemodialyzed patients. Eleven intracranial arteries were analyzed for calcification score, while internal carotid arteries and vertebral arteries were excluded in cerebral artery calcification score. As a control group for assessing intracranial calcifications, we have analyzed computed tomographic scans from diabetic patients who had an acute stroke.
Results
Deceased patients had significantly higher values of augmentation index and pulse wave velocity, lower ankle-brachial index, and higher internal carotid arteries peak systolic value than survived patients. Deceased patients had significantly higher number of calcified middle cerebral arteries as well as significantly higher intracranial artery calcification score and cerebral artery calcification score. Hemodialyzed patients had significantly higher both intracranial and cerebral artery calcification scores than diabetic control group. Age and calcified middle cerebral arteries had increased HR of 1.08 and 1.36 for cardiovascular mortality.
Conclusion
This study showed that large artery stiffness and not the presence of peripheral arterial disease or carotid artery stenosis have the prognostic role of middle cerebral arteries’ calcifications and cardiovascular mortality in hemodialyzed patients. The presence of middle cerebral arteries’ calcifications diagnosed by a non-invasive method should be considered a marker of middle-sized conduit arteries atherosclerosis, subclinical brain damage, and future fatal cardiovascular events.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-021-03092-2</identifier><identifier>PMID: 35031973</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Ankle ; Arteriosclerosis ; Atherosclerosis ; Brain injury ; Calcification ; Calcification (ectopic) ; Cardiovascular diseases ; Carotid arteries ; Carotid artery ; Computed tomography ; Diabetes ; Diabetes mellitus ; Hemodialysis ; Medicine ; Medicine & Public Health ; Mortality ; Nephrology ; Nephrology - Original Paper ; Patients ; Stenosis ; Urology ; Veins & arteries ; Vertebrae</subject><ispartof>International urology and nephrology, 2022-08, Vol.54 (8), p.1995-2004</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-bfe2ae036820575db713a7d4e12abdd6537284f68e0f2a6f40a3b9fa5942dc143</cites><orcidid>0000-0001-6264-6809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-021-03092-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-021-03092-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35031973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Premužić, Vedran</creatorcontrib><creatorcontrib>Gardijan, Danilo</creatorcontrib><creatorcontrib>Herega, Tomislav</creatorcontrib><creatorcontrib>Perkov, Dražen</creatorcontrib><creatorcontrib>Jelaković, Bojan</creatorcontrib><title>High prevalence of middle cerebral artery calcification is associated with cardiovascular mortality in hemodialyzed patients: an overlooked part of arterial tree?</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
We have analyzed markers of accelerated atherosclerosis like large artery stiffness, ankle-brachial index, carotid and vertebral duplex ultrasonography and their possible associations with the incidence of intracranial calcifications, clinical course of hemodialyzed patients, and cardiovascular mortality.
Methods
A computed tomographic scan of the head was performed for any neurological indication on 100 hemodialyzed patients. Eleven intracranial arteries were analyzed for calcification score, while internal carotid arteries and vertebral arteries were excluded in cerebral artery calcification score. As a control group for assessing intracranial calcifications, we have analyzed computed tomographic scans from diabetic patients who had an acute stroke.
Results
Deceased patients had significantly higher values of augmentation index and pulse wave velocity, lower ankle-brachial index, and higher internal carotid arteries peak systolic value than survived patients. Deceased patients had significantly higher number of calcified middle cerebral arteries as well as significantly higher intracranial artery calcification score and cerebral artery calcification score. Hemodialyzed patients had significantly higher both intracranial and cerebral artery calcification scores than diabetic control group. Age and calcified middle cerebral arteries had increased HR of 1.08 and 1.36 for cardiovascular mortality.
Conclusion
This study showed that large artery stiffness and not the presence of peripheral arterial disease or carotid artery stenosis have the prognostic role of middle cerebral arteries’ calcifications and cardiovascular mortality in hemodialyzed patients. The presence of middle cerebral arteries’ calcifications diagnosed by a non-invasive method should be considered a marker of middle-sized conduit arteries atherosclerosis, subclinical brain damage, and future fatal cardiovascular events.</description><subject>Ankle</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Brain injury</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiovascular diseases</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Computed tomography</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Hemodialysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Patients</subject><subject>Stenosis</subject><subject>Urology</subject><subject>Veins & arteries</subject><subject>Vertebrae</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc9u1DAQhyMEoqXwAhyQJS5cQsd2nD9cUFVRilSJS3uOJvak6-LEi-0sWh6HJ613t0DFgZMtzze_Gfkritcc3nOA5jRyLpQqQfASJHSiFE-KY64aWQrVVk8f3Y-KFzHeAUDXAjwvjqQCybtGHhe_Lu3tiq0DbdDRrIn5kU3WGEdMU6AhoGMYEoUt0-i0Ha3GZP3MbGQYo9cWExn2w6ZVBoKxfoNRLw4Dm3xI6GzaMjuzFU3eWHTbn5le5wiaU_zAcGZ-Q8F5_23_HtJugf3ADLMUiD6-LJ6N6CK9ejhPipuLT9fnl-XV189fzs-uSi1FncphJIEEsm4FqEaZoeESG1MRFzgYUyvZiLYa65ZgFFiPFaAcuhFVVwmjeSVPineH3HXw3xeKqZ9s1OQczuSX2ItaALT5AyGjb_9B7_wS5rxdplrV8lbVO0ocKB18jIHGfh3shGHbc-h3BvuDwT4b7PcGe5Gb3jxEL8NE5k_Lb2UZkAcg5tJ8S-Hv7P_E3gOW86m-</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Premužić, Vedran</creator><creator>Gardijan, Danilo</creator><creator>Herega, Tomislav</creator><creator>Perkov, Dražen</creator><creator>Jelaković, Bojan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6264-6809</orcidid></search><sort><creationdate>20220801</creationdate><title>High prevalence of middle cerebral artery calcification is associated with cardiovascular mortality in hemodialyzed patients: an overlooked part of arterial tree?</title><author>Premužić, Vedran ; Gardijan, Danilo ; Herega, Tomislav ; Perkov, Dražen ; Jelaković, Bojan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-bfe2ae036820575db713a7d4e12abdd6537284f68e0f2a6f40a3b9fa5942dc143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ankle</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Brain injury</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Cardiovascular diseases</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Computed tomography</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Hemodialysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Patients</topic><topic>Stenosis</topic><topic>Urology</topic><topic>Veins & arteries</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Premužić, Vedran</creatorcontrib><creatorcontrib>Gardijan, Danilo</creatorcontrib><creatorcontrib>Herega, Tomislav</creatorcontrib><creatorcontrib>Perkov, Dražen</creatorcontrib><creatorcontrib>Jelaković, Bojan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Premužić, Vedran</au><au>Gardijan, Danilo</au><au>Herega, Tomislav</au><au>Perkov, Dražen</au><au>Jelaković, Bojan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of middle cerebral artery calcification is associated with cardiovascular mortality in hemodialyzed patients: an overlooked part of arterial tree?</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>54</volume><issue>8</issue><spage>1995</spage><epage>2004</epage><pages>1995-2004</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Purpose
We have analyzed markers of accelerated atherosclerosis like large artery stiffness, ankle-brachial index, carotid and vertebral duplex ultrasonography and their possible associations with the incidence of intracranial calcifications, clinical course of hemodialyzed patients, and cardiovascular mortality.
Methods
A computed tomographic scan of the head was performed for any neurological indication on 100 hemodialyzed patients. Eleven intracranial arteries were analyzed for calcification score, while internal carotid arteries and vertebral arteries were excluded in cerebral artery calcification score. As a control group for assessing intracranial calcifications, we have analyzed computed tomographic scans from diabetic patients who had an acute stroke.
Results
Deceased patients had significantly higher values of augmentation index and pulse wave velocity, lower ankle-brachial index, and higher internal carotid arteries peak systolic value than survived patients. Deceased patients had significantly higher number of calcified middle cerebral arteries as well as significantly higher intracranial artery calcification score and cerebral artery calcification score. Hemodialyzed patients had significantly higher both intracranial and cerebral artery calcification scores than diabetic control group. Age and calcified middle cerebral arteries had increased HR of 1.08 and 1.36 for cardiovascular mortality.
Conclusion
This study showed that large artery stiffness and not the presence of peripheral arterial disease or carotid artery stenosis have the prognostic role of middle cerebral arteries’ calcifications and cardiovascular mortality in hemodialyzed patients. The presence of middle cerebral arteries’ calcifications diagnosed by a non-invasive method should be considered a marker of middle-sized conduit arteries atherosclerosis, subclinical brain damage, and future fatal cardiovascular events.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>35031973</pmid><doi>10.1007/s11255-021-03092-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6264-6809</orcidid></addata></record> |
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| ispartof | International urology and nephrology, 2022-08, Vol.54 (8), p.1995-2004 |
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| subjects | Ankle Arteriosclerosis Atherosclerosis Brain injury Calcification Calcification (ectopic) Cardiovascular diseases Carotid arteries Carotid artery Computed tomography Diabetes Diabetes mellitus Hemodialysis Medicine Medicine & Public Health Mortality Nephrology Nephrology - Original Paper Patients Stenosis Urology Veins & arteries Vertebrae |
| title | High prevalence of middle cerebral artery calcification is associated with cardiovascular mortality in hemodialyzed patients: an overlooked part of arterial tree? |
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