Vγ5Vδ1 TCR signaling is required to different extents for embryonic versus postnatal development of DETCs

Abstract γδ T cells expressing Vγ5Vδ1 TCR originally develop in the embryonic thymus and migrate to the epidermis, forming dendritic epidermal T cells (DETCs) throughout life. It is thought that a TCR signal is essential for their development; e.g., lack of TCR signal-transducer ZAP70 significantly...

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Veröffentlicht in:	International immunology 2022-04, Vol.34 (5), p.263-276
Hauptverfasser:	Sudo, Koichi, Todoroki, Takero, Ka, Yuyo, Takahara, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Epidermal Cells Epidermis Mice Mice, Inbred C57BL Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, gamma-delta Signal Transduction T-Lymphocytes - physiology
Online-Zugang:	Volltext
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