Role of histone demethylases and histone methyltransferases in triple-negative breast cancer: Epigenetic mnemonics

Triple-negative breast cancer (TNBC) is a particularly lethal subtype of breast cancer owing to its heterogeneity, high drug resistance, poor prognosis and lack of therapeutic targets. Recent insights into the complexity of TNBC have been explained by epigenetic regulation and its ability to modulat...

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Veröffentlicht in:	Life sciences (1973) 2022-03, Vol.292, p.120321-120321, Article 120321
Hauptverfasser:	Mandumpala, Janice Jacson, Baby, Stephin, Tom, Antriya Annie, Godugu, Chandraiah, Shankaraiah, Nagula
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Demethylation Drug development Drug resistance Epi-drugs Epigenesis, Genetic Epigenetics Female Gene Expression Regulation, Neoplastic Heterogeneity Histone Demethylases - physiology Histone demethylases inhibitors Histone methyltransferase inhibitors Histone Methyltransferases - physiology Histones Humans Methylation Oncogenes Therapeutic targets Triple Negative Breast Neoplasms - metabolism Triple-negative breast cancer Tumor suppressor genes Tumorigenesis Tumors
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