Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases
Purpose The purpose of this study was to investigate survival outcomes and safety after chemoembolization using irinotecan-loaded small-size beads (DEB-IRI) in patients with colorectal liver metastases unresponsive to standard chemotherapy. Materials and methods Between December 2013 and August 2019...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2022-06, Vol.45 (6), p.770-779 |
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| creator | Mauri, Giovanni Rossi, Duccio Frassoni, Samuele Bonomo, Guido Camisassi, Nicola Della Vigna, Paolo Bagnardi, Vincenzo Maiettini, Daniele Varano, Gianluca Maria Zampino, Maria Giulia Orsi, Franco |
| description | Purpose
The purpose of this study was to investigate survival outcomes and safety after chemoembolization using irinotecan-loaded small-size beads (DEB-IRI) in patients with colorectal liver metastases unresponsive to standard chemotherapy.
Materials and methods
Between December 2013 and August 2019, fifty-five patients (32 males, median age 64.5 years) with pretreated colorectal liver metastases unresponsive to standard chemotherapy underwent 197 chemoembolization procedures (mean 3.6 ± 2.3 SD per patient). Thirty patients (30/55; 55%) had extrahepatic disease metastatic to the lungs, lymph nodes or peritoneum. Local tumor control was evaluated at 3, 6, 9 and 12 months. Median overall survival, survival rates at 1 and 2 year and adverse events were evaluated.
Results
Local tumor control was achieved in 32/55 (58%), 12/55 (22%), 4/55 (7%) and 2/55 (4%) patients at 3, 6, 9 and 12 months, respectively. Median overall survival was 9.9 months (95% CI: 6.2–14.2 months) with 1- and 2-year survival rates of 45% and 15%, respectively. A total of 30 (15%) G1-G3 treatment-related adverse events occurred across all embolization procedures. No severe treatment-related adverse events occurred.
Conclusion
Chemoembolization using irinotecan-loaded small-size beads is a safe and effective procedure as a salvage treatment in patients with colorectal liver metastases, showing good results in terms of liver-specific progression free survival and overall survival. |
| doi_str_mv | 10.1007/s00270-021-03039-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2620082687</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2620082687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-18b4489a3d0b485d47de55b9977a34ede10f7c3e39212cb685eb97afbf9871053</originalsourceid><addsrcrecordid>eNp9kdFqFTEQhkNR2mP1BXohAW_ai9hJstkkl_ZgbeFIBSt4F7K7s-2W3U1NchT7NL6EL9AnM7pVwQthYAbmm3-G-Qk54PCSA-jjBCA0MBCcgQRpGd8hK15JwcDUHx-RFXBdMa4U3yNPUroB4MoItUv2pAJhNdgVCe8nP44sDXdIDyu4_3b_fTqiJ-i7RDfBd9jRL0O-pudxmEPG1s90mGm-RnoZ0ecJ50xDT9_5PJQyLfA6jCFim_1IN8NnjPQtZp9KYHpKHvd-TPjsIe-TD6evL9dnbHPx5nz9asNaCSozbpqqMtbLDprKqK7SHSrVWKu1lxV2yKHXrURpBRdtUxuFjdW-b3prNAcl98nhonsbw6ctpuymIbU4jn7GsE1O1ALAiNrogr74B70J2ziX6wpV15wLo6BQYqHaGFKK2LvbOEw-fnUc3E873GKHK3a4X3Y4XoaeP0hvmwm7PyO__18AuQCptOYrjH93_0f2B3rvlW0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2666112850</pqid></control><display><type>article</type><title>Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Mauri, Giovanni ; Rossi, Duccio ; Frassoni, Samuele ; Bonomo, Guido ; Camisassi, Nicola ; Della Vigna, Paolo ; Bagnardi, Vincenzo ; Maiettini, Daniele ; Varano, Gianluca Maria ; Zampino, Maria Giulia ; Orsi, Franco</creator><creatorcontrib>Mauri, Giovanni ; Rossi, Duccio ; Frassoni, Samuele ; Bonomo, Guido ; Camisassi, Nicola ; Della Vigna, Paolo ; Bagnardi, Vincenzo ; Maiettini, Daniele ; Varano, Gianluca Maria ; Zampino, Maria Giulia ; Orsi, Franco</creatorcontrib><description>Purpose
The purpose of this study was to investigate survival outcomes and safety after chemoembolization using irinotecan-loaded small-size beads (DEB-IRI) in patients with colorectal liver metastases unresponsive to standard chemotherapy.
Materials and methods
Between December 2013 and August 2019, fifty-five patients (32 males, median age 64.5 years) with pretreated colorectal liver metastases unresponsive to standard chemotherapy underwent 197 chemoembolization procedures (mean 3.6 ± 2.3 SD per patient). Thirty patients (30/55; 55%) had extrahepatic disease metastatic to the lungs, lymph nodes or peritoneum. Local tumor control was evaluated at 3, 6, 9 and 12 months. Median overall survival, survival rates at 1 and 2 year and adverse events were evaluated.
Results
Local tumor control was achieved in 32/55 (58%), 12/55 (22%), 4/55 (7%) and 2/55 (4%) patients at 3, 6, 9 and 12 months, respectively. Median overall survival was 9.9 months (95% CI: 6.2–14.2 months) with 1- and 2-year survival rates of 45% and 15%, respectively. A total of 30 (15%) G1-G3 treatment-related adverse events occurred across all embolization procedures. No severe treatment-related adverse events occurred.
Conclusion
Chemoembolization using irinotecan-loaded small-size beads is a safe and effective procedure as a salvage treatment in patients with colorectal liver metastases, showing good results in terms of liver-specific progression free survival and overall survival.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-021-03039-1</identifier><identifier>PMID: 35029709</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adverse events ; Beads ; Cardiology ; Chemoembolization ; Chemoembolization, Therapeutic - methods ; Chemotherapy ; Clinical Investigation ; Colorectal Neoplasms - pathology ; Embolization ; Humans ; Imaging ; Interventional Oncology ; Irinotecan ; Liver ; Liver Neoplasms - drug therapy ; Liver Neoplasms - secondary ; Lung diseases ; Lymph nodes ; Male ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Microspheres ; Middle Aged ; Nuclear Medicine ; Patients ; Peritoneum ; Radiology ; Survival ; Survival Rate ; Treatment Outcome ; Tumors ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2022-06, Vol.45 (6), p.770-779</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021</rights><rights>2021. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-18b4489a3d0b485d47de55b9977a34ede10f7c3e39212cb685eb97afbf9871053</citedby><cites>FETCH-LOGICAL-c305t-18b4489a3d0b485d47de55b9977a34ede10f7c3e39212cb685eb97afbf9871053</cites><orcidid>0000-0002-6711-8084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-021-03039-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-021-03039-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35029709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mauri, Giovanni</creatorcontrib><creatorcontrib>Rossi, Duccio</creatorcontrib><creatorcontrib>Frassoni, Samuele</creatorcontrib><creatorcontrib>Bonomo, Guido</creatorcontrib><creatorcontrib>Camisassi, Nicola</creatorcontrib><creatorcontrib>Della Vigna, Paolo</creatorcontrib><creatorcontrib>Bagnardi, Vincenzo</creatorcontrib><creatorcontrib>Maiettini, Daniele</creatorcontrib><creatorcontrib>Varano, Gianluca Maria</creatorcontrib><creatorcontrib>Zampino, Maria Giulia</creatorcontrib><creatorcontrib>Orsi, Franco</creatorcontrib><title>Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
The purpose of this study was to investigate survival outcomes and safety after chemoembolization using irinotecan-loaded small-size beads (DEB-IRI) in patients with colorectal liver metastases unresponsive to standard chemotherapy.
Materials and methods
Between December 2013 and August 2019, fifty-five patients (32 males, median age 64.5 years) with pretreated colorectal liver metastases unresponsive to standard chemotherapy underwent 197 chemoembolization procedures (mean 3.6 ± 2.3 SD per patient). Thirty patients (30/55; 55%) had extrahepatic disease metastatic to the lungs, lymph nodes or peritoneum. Local tumor control was evaluated at 3, 6, 9 and 12 months. Median overall survival, survival rates at 1 and 2 year and adverse events were evaluated.
Results
Local tumor control was achieved in 32/55 (58%), 12/55 (22%), 4/55 (7%) and 2/55 (4%) patients at 3, 6, 9 and 12 months, respectively. Median overall survival was 9.9 months (95% CI: 6.2–14.2 months) with 1- and 2-year survival rates of 45% and 15%, respectively. A total of 30 (15%) G1-G3 treatment-related adverse events occurred across all embolization procedures. No severe treatment-related adverse events occurred.
Conclusion
Chemoembolization using irinotecan-loaded small-size beads is a safe and effective procedure as a salvage treatment in patients with colorectal liver metastases, showing good results in terms of liver-specific progression free survival and overall survival.</description><subject>Adverse events</subject><subject>Beads</subject><subject>Cardiology</subject><subject>Chemoembolization</subject><subject>Chemoembolization, Therapeutic - methods</subject><subject>Chemotherapy</subject><subject>Clinical Investigation</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Embolization</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interventional Oncology</subject><subject>Irinotecan</subject><subject>Liver</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung diseases</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Microspheres</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Peritoneum</subject><subject>Radiology</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kdFqFTEQhkNR2mP1BXohAW_ai9hJstkkl_ZgbeFIBSt4F7K7s-2W3U1NchT7NL6EL9AnM7pVwQthYAbmm3-G-Qk54PCSA-jjBCA0MBCcgQRpGd8hK15JwcDUHx-RFXBdMa4U3yNPUroB4MoItUv2pAJhNdgVCe8nP44sDXdIDyu4_3b_fTqiJ-i7RDfBd9jRL0O-pudxmEPG1s90mGm-RnoZ0ecJ50xDT9_5PJQyLfA6jCFim_1IN8NnjPQtZp9KYHpKHvd-TPjsIe-TD6evL9dnbHPx5nz9asNaCSozbpqqMtbLDprKqK7SHSrVWKu1lxV2yKHXrURpBRdtUxuFjdW-b3prNAcl98nhonsbw6ctpuymIbU4jn7GsE1O1ALAiNrogr74B70J2ziX6wpV15wLo6BQYqHaGFKK2LvbOEw-fnUc3E873GKHK3a4X3Y4XoaeP0hvmwm7PyO__18AuQCptOYrjH93_0f2B3rvlW0</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Mauri, Giovanni</creator><creator>Rossi, Duccio</creator><creator>Frassoni, Samuele</creator><creator>Bonomo, Guido</creator><creator>Camisassi, Nicola</creator><creator>Della Vigna, Paolo</creator><creator>Bagnardi, Vincenzo</creator><creator>Maiettini, Daniele</creator><creator>Varano, Gianluca Maria</creator><creator>Zampino, Maria Giulia</creator><creator>Orsi, Franco</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6711-8084</orcidid></search><sort><creationdate>202206</creationdate><title>Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases</title><author>Mauri, Giovanni ; Rossi, Duccio ; Frassoni, Samuele ; Bonomo, Guido ; Camisassi, Nicola ; Della Vigna, Paolo ; Bagnardi, Vincenzo ; Maiettini, Daniele ; Varano, Gianluca Maria ; Zampino, Maria Giulia ; Orsi, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-18b4489a3d0b485d47de55b9977a34ede10f7c3e39212cb685eb97afbf9871053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adverse events</topic><topic>Beads</topic><topic>Cardiology</topic><topic>Chemoembolization</topic><topic>Chemoembolization, Therapeutic - methods</topic><topic>Chemotherapy</topic><topic>Clinical Investigation</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Embolization</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interventional Oncology</topic><topic>Irinotecan</topic><topic>Liver</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung diseases</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Microspheres</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Peritoneum</topic><topic>Radiology</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauri, Giovanni</creatorcontrib><creatorcontrib>Rossi, Duccio</creatorcontrib><creatorcontrib>Frassoni, Samuele</creatorcontrib><creatorcontrib>Bonomo, Guido</creatorcontrib><creatorcontrib>Camisassi, Nicola</creatorcontrib><creatorcontrib>Della Vigna, Paolo</creatorcontrib><creatorcontrib>Bagnardi, Vincenzo</creatorcontrib><creatorcontrib>Maiettini, Daniele</creatorcontrib><creatorcontrib>Varano, Gianluca Maria</creatorcontrib><creatorcontrib>Zampino, Maria Giulia</creatorcontrib><creatorcontrib>Orsi, Franco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauri, Giovanni</au><au>Rossi, Duccio</au><au>Frassoni, Samuele</au><au>Bonomo, Guido</au><au>Camisassi, Nicola</au><au>Della Vigna, Paolo</au><au>Bagnardi, Vincenzo</au><au>Maiettini, Daniele</au><au>Varano, Gianluca Maria</au><au>Zampino, Maria Giulia</au><au>Orsi, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2022-06</date><risdate>2022</risdate><volume>45</volume><issue>6</issue><spage>770</spage><epage>779</epage><pages>770-779</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
The purpose of this study was to investigate survival outcomes and safety after chemoembolization using irinotecan-loaded small-size beads (DEB-IRI) in patients with colorectal liver metastases unresponsive to standard chemotherapy.
Materials and methods
Between December 2013 and August 2019, fifty-five patients (32 males, median age 64.5 years) with pretreated colorectal liver metastases unresponsive to standard chemotherapy underwent 197 chemoembolization procedures (mean 3.6 ± 2.3 SD per patient). Thirty patients (30/55; 55%) had extrahepatic disease metastatic to the lungs, lymph nodes or peritoneum. Local tumor control was evaluated at 3, 6, 9 and 12 months. Median overall survival, survival rates at 1 and 2 year and adverse events were evaluated.
Results
Local tumor control was achieved in 32/55 (58%), 12/55 (22%), 4/55 (7%) and 2/55 (4%) patients at 3, 6, 9 and 12 months, respectively. Median overall survival was 9.9 months (95% CI: 6.2–14.2 months) with 1- and 2-year survival rates of 45% and 15%, respectively. A total of 30 (15%) G1-G3 treatment-related adverse events occurred across all embolization procedures. No severe treatment-related adverse events occurred.
Conclusion
Chemoembolization using irinotecan-loaded small-size beads is a safe and effective procedure as a salvage treatment in patients with colorectal liver metastases, showing good results in terms of liver-specific progression free survival and overall survival.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35029709</pmid><doi>10.1007/s00270-021-03039-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6711-8084</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0174-1551 |
| ispartof | Cardiovascular and interventional radiology, 2022-06, Vol.45 (6), p.770-779 |
| issn | 0174-1551 1432-086X |
| language | eng |
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| subjects | Adverse events Beads Cardiology Chemoembolization Chemoembolization, Therapeutic - methods Chemotherapy Clinical Investigation Colorectal Neoplasms - pathology Embolization Humans Imaging Interventional Oncology Irinotecan Liver Liver Neoplasms - drug therapy Liver Neoplasms - secondary Lung diseases Lymph nodes Male Medicine Medicine & Public Health Metastases Metastasis Microspheres Middle Aged Nuclear Medicine Patients Peritoneum Radiology Survival Survival Rate Treatment Outcome Tumors Ultrasound |
| title | Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases |
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