Validation of a food-frequency questionnaire to assess methyl-group donor intake in preschoolers
A good assessment of dietary methyl-group donor intake (folate, choline, betaine, methionine) is needed to investigate the effect of methyl-group donor intake on children’s health. The aim is to develop and validate a food-frequency questionnaire (FFQ) to estimate the daily intake of methyl-group do...
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| Veröffentlicht in: | European journal of pediatrics 2022-05, Vol.181 (5), p.1871-1881 |
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| creator | Hoeylaerts, Sarah Van Opstal, Annelies Huybrechts, Inge Koppen, Gudrun Devlieger, Roland Godderis, Lode Pauwels, Sara |
| description | A good assessment of dietary methyl-group donor intake (folate, choline, betaine, methionine) is needed to investigate the effect of methyl-group donor intake on children’s health. The aim is to develop and validate a food-frequency questionnaire (FFQ) to estimate the daily intake of methyl-group donors in preschoolers. For the relative validity and reproducibility of the FFQ, a 7-day estimated dietary record (7d EDR) and repeated measurements 6 weeks apart (
n
= 77) were used respectively. For the validity (
n
= 75), a moderate ranking ability was obtained (de-attenuated Pearson correlation = 0.43–0.70; weighted
ƙ
0.10–0.40), but the FFQ tends to overestimate the real intake. Cross-classification analysis showed that 38% (choline) and 28% (betaine) of the subjects were misclassified. The FFQ shows a moderate to good reproducibility, intra-class correlation coefficients range between 0.67 (betaine) and 0.76 (choline) with a maximal misclassification of 6.5% for betaine (weighted ƙ 0.37–0.69) (
n
= 77).
Conclusion
: The FFQ is a tool with a moderate validity and reproducibility to estimate the consumption of dietary methyl-group donors in preschoolers. This tool might be used in future research epidemiological studies including preschoolers.
What is Known:
• Poor dietary habits during childhood have been associated with chronic disease in adulthood.
• Methyl-group donors are important for DNA methylation, which is the underlying mechanism of disease development.
What is New:
• For the first time, a food-frequency questionnaire that can assess the intake of methione, folate, choline, and betaine has been developed and validated for the use in preschoolers. |
| doi_str_mv | 10.1007/s00431-021-04367-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2620082643</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2620082643</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-2cd9141103e56c9de7a738c1d01613c367be44fb5dbf260efd0ea13a4f078eb13</originalsourceid><addsrcrecordid>eNp9kEFP3DAQha2qqFDgD3BAlrj0kjJjO_HmWCEKlZB6Aa7Gsce7odl4ayeH_fc1LJSKQw_WszTfex4_xk4QviKAPs8ASmIFohwlG13pD-wAlRQVgm4-_nPfZ59zfoRianHxie3LGkSrFR6wh3s79N5OfRx5DNzyEKOvQqLfM41uy4vkp-Fo-0R8itzmTDnzNU2r7VAtU5w33McxJt6Pk_1FRfgmUXarGAdK-YjtBTtkOn7RQ3b3_fL24rq6-Xn14-LbTeWkrqdKON-iQgRJdeNaT9pquXDoARuUrvyuI6VCV_suiAYoeCCL0qoAekEdykP2ZZe7SfF5abPus6NhsCPFORvRCICFaJQs6Nk79DHOaSzbFarWNQK2UCixo1yKOScKZpP6tU1bg2Ce-je7_k3p3zz3b3Qxnb5Ez92a_F_La-EFkDsgl9G4pPT29n9i_wDCQpEV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2657510190</pqid></control><display><type>article</type><title>Validation of a food-frequency questionnaire to assess methyl-group donor intake in preschoolers</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Hoeylaerts, Sarah ; Van Opstal, Annelies ; Huybrechts, Inge ; Koppen, Gudrun ; Devlieger, Roland ; Godderis, Lode ; Pauwels, Sara</creator><creatorcontrib>Hoeylaerts, Sarah ; Van Opstal, Annelies ; Huybrechts, Inge ; Koppen, Gudrun ; Devlieger, Roland ; Godderis, Lode ; Pauwels, Sara</creatorcontrib><description>A good assessment of dietary methyl-group donor intake (folate, choline, betaine, methionine) is needed to investigate the effect of methyl-group donor intake on children’s health. The aim is to develop and validate a food-frequency questionnaire (FFQ) to estimate the daily intake of methyl-group donors in preschoolers. For the relative validity and reproducibility of the FFQ, a 7-day estimated dietary record (7d EDR) and repeated measurements 6 weeks apart (
n
= 77) were used respectively. For the validity (
n
= 75), a moderate ranking ability was obtained (de-attenuated Pearson correlation = 0.43–0.70; weighted
ƙ
0.10–0.40), but the FFQ tends to overestimate the real intake. Cross-classification analysis showed that 38% (choline) and 28% (betaine) of the subjects were misclassified. The FFQ shows a moderate to good reproducibility, intra-class correlation coefficients range between 0.67 (betaine) and 0.76 (choline) with a maximal misclassification of 6.5% for betaine (weighted ƙ 0.37–0.69) (
n
= 77).
Conclusion
: The FFQ is a tool with a moderate validity and reproducibility to estimate the consumption of dietary methyl-group donors in preschoolers. This tool might be used in future research epidemiological studies including preschoolers.
What is Known:
• Poor dietary habits during childhood have been associated with chronic disease in adulthood.
• Methyl-group donors are important for DNA methylation, which is the underlying mechanism of disease development.
What is New:
• For the first time, a food-frequency questionnaire that can assess the intake of methione, folate, choline, and betaine has been developed and validated for the use in preschoolers.</description><identifier>ISSN: 1432-1076</identifier><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-021-04367-7</identifier><identifier>PMID: 35029741</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Betaine ; Child ; Children ; Choline ; Chronic illnesses ; Diet ; Diet Records ; Diet Surveys ; Dietary intake ; DNA methylation ; Energy Intake ; Epidemiology ; Folic Acid ; Food ; Humans ; Medicine ; Medicine & Public Health ; Methionine ; Original Article ; Pediatrics ; Preschool children ; Questionnaires ; Reproducibility ; Reproducibility of Results ; Surveys and Questionnaires ; Validity</subject><ispartof>European journal of pediatrics, 2022-05, Vol.181 (5), p.1871-1881</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-2cd9141103e56c9de7a738c1d01613c367be44fb5dbf260efd0ea13a4f078eb13</citedby><cites>FETCH-LOGICAL-c375t-2cd9141103e56c9de7a738c1d01613c367be44fb5dbf260efd0ea13a4f078eb13</cites><orcidid>0000-0002-4335-4867</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00431-021-04367-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00431-021-04367-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35029741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoeylaerts, Sarah</creatorcontrib><creatorcontrib>Van Opstal, Annelies</creatorcontrib><creatorcontrib>Huybrechts, Inge</creatorcontrib><creatorcontrib>Koppen, Gudrun</creatorcontrib><creatorcontrib>Devlieger, Roland</creatorcontrib><creatorcontrib>Godderis, Lode</creatorcontrib><creatorcontrib>Pauwels, Sara</creatorcontrib><title>Validation of a food-frequency questionnaire to assess methyl-group donor intake in preschoolers</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>A good assessment of dietary methyl-group donor intake (folate, choline, betaine, methionine) is needed to investigate the effect of methyl-group donor intake on children’s health. The aim is to develop and validate a food-frequency questionnaire (FFQ) to estimate the daily intake of methyl-group donors in preschoolers. For the relative validity and reproducibility of the FFQ, a 7-day estimated dietary record (7d EDR) and repeated measurements 6 weeks apart (
n
= 77) were used respectively. For the validity (
n
= 75), a moderate ranking ability was obtained (de-attenuated Pearson correlation = 0.43–0.70; weighted
ƙ
0.10–0.40), but the FFQ tends to overestimate the real intake. Cross-classification analysis showed that 38% (choline) and 28% (betaine) of the subjects were misclassified. The FFQ shows a moderate to good reproducibility, intra-class correlation coefficients range between 0.67 (betaine) and 0.76 (choline) with a maximal misclassification of 6.5% for betaine (weighted ƙ 0.37–0.69) (
n
= 77).
Conclusion
: The FFQ is a tool with a moderate validity and reproducibility to estimate the consumption of dietary methyl-group donors in preschoolers. This tool might be used in future research epidemiological studies including preschoolers.
What is Known:
• Poor dietary habits during childhood have been associated with chronic disease in adulthood.
• Methyl-group donors are important for DNA methylation, which is the underlying mechanism of disease development.
What is New:
• For the first time, a food-frequency questionnaire that can assess the intake of methione, folate, choline, and betaine has been developed and validated for the use in preschoolers.</description><subject>Adult</subject><subject>Betaine</subject><subject>Child</subject><subject>Children</subject><subject>Choline</subject><subject>Chronic illnesses</subject><subject>Diet</subject><subject>Diet Records</subject><subject>Diet Surveys</subject><subject>Dietary intake</subject><subject>DNA methylation</subject><subject>Energy Intake</subject><subject>Epidemiology</subject><subject>Folic Acid</subject><subject>Food</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methionine</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Preschool children</subject><subject>Questionnaires</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Surveys and Questionnaires</subject><subject>Validity</subject><issn>1432-1076</issn><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kEFP3DAQha2qqFDgD3BAlrj0kjJjO_HmWCEKlZB6Aa7Gsce7odl4ayeH_fc1LJSKQw_WszTfex4_xk4QviKAPs8ASmIFohwlG13pD-wAlRQVgm4-_nPfZ59zfoRianHxie3LGkSrFR6wh3s79N5OfRx5DNzyEKOvQqLfM41uy4vkp-Fo-0R8itzmTDnzNU2r7VAtU5w33McxJt6Pk_1FRfgmUXarGAdK-YjtBTtkOn7RQ3b3_fL24rq6-Xn14-LbTeWkrqdKON-iQgRJdeNaT9pquXDoARuUrvyuI6VCV_suiAYoeCCL0qoAekEdykP2ZZe7SfF5abPus6NhsCPFORvRCICFaJQs6Nk79DHOaSzbFarWNQK2UCixo1yKOScKZpP6tU1bg2Ce-je7_k3p3zz3b3Qxnb5Ez92a_F_La-EFkDsgl9G4pPT29n9i_wDCQpEV</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Hoeylaerts, Sarah</creator><creator>Van Opstal, Annelies</creator><creator>Huybrechts, Inge</creator><creator>Koppen, Gudrun</creator><creator>Devlieger, Roland</creator><creator>Godderis, Lode</creator><creator>Pauwels, Sara</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4335-4867</orcidid></search><sort><creationdate>20220501</creationdate><title>Validation of a food-frequency questionnaire to assess methyl-group donor intake in preschoolers</title><author>Hoeylaerts, Sarah ; Van Opstal, Annelies ; Huybrechts, Inge ; Koppen, Gudrun ; Devlieger, Roland ; Godderis, Lode ; Pauwels, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-2cd9141103e56c9de7a738c1d01613c367be44fb5dbf260efd0ea13a4f078eb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Betaine</topic><topic>Child</topic><topic>Children</topic><topic>Choline</topic><topic>Chronic illnesses</topic><topic>Diet</topic><topic>Diet Records</topic><topic>Diet Surveys</topic><topic>Dietary intake</topic><topic>DNA methylation</topic><topic>Energy Intake</topic><topic>Epidemiology</topic><topic>Folic Acid</topic><topic>Food</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methionine</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Preschool children</topic><topic>Questionnaires</topic><topic>Reproducibility</topic><topic>Reproducibility of Results</topic><topic>Surveys and Questionnaires</topic><topic>Validity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoeylaerts, Sarah</creatorcontrib><creatorcontrib>Van Opstal, Annelies</creatorcontrib><creatorcontrib>Huybrechts, Inge</creatorcontrib><creatorcontrib>Koppen, Gudrun</creatorcontrib><creatorcontrib>Devlieger, Roland</creatorcontrib><creatorcontrib>Godderis, Lode</creatorcontrib><creatorcontrib>Pauwels, Sara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoeylaerts, Sarah</au><au>Van Opstal, Annelies</au><au>Huybrechts, Inge</au><au>Koppen, Gudrun</au><au>Devlieger, Roland</au><au>Godderis, Lode</au><au>Pauwels, Sara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of a food-frequency questionnaire to assess methyl-group donor intake in preschoolers</atitle><jtitle>European journal of pediatrics</jtitle><stitle>Eur J Pediatr</stitle><addtitle>Eur J Pediatr</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>181</volume><issue>5</issue><spage>1871</spage><epage>1881</epage><pages>1871-1881</pages><issn>1432-1076</issn><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>A good assessment of dietary methyl-group donor intake (folate, choline, betaine, methionine) is needed to investigate the effect of methyl-group donor intake on children’s health. The aim is to develop and validate a food-frequency questionnaire (FFQ) to estimate the daily intake of methyl-group donors in preschoolers. For the relative validity and reproducibility of the FFQ, a 7-day estimated dietary record (7d EDR) and repeated measurements 6 weeks apart (
n
= 77) were used respectively. For the validity (
n
= 75), a moderate ranking ability was obtained (de-attenuated Pearson correlation = 0.43–0.70; weighted
ƙ
0.10–0.40), but the FFQ tends to overestimate the real intake. Cross-classification analysis showed that 38% (choline) and 28% (betaine) of the subjects were misclassified. The FFQ shows a moderate to good reproducibility, intra-class correlation coefficients range between 0.67 (betaine) and 0.76 (choline) with a maximal misclassification of 6.5% for betaine (weighted ƙ 0.37–0.69) (
n
= 77).
Conclusion
: The FFQ is a tool with a moderate validity and reproducibility to estimate the consumption of dietary methyl-group donors in preschoolers. This tool might be used in future research epidemiological studies including preschoolers.
What is Known:
• Poor dietary habits during childhood have been associated with chronic disease in adulthood.
• Methyl-group donors are important for DNA methylation, which is the underlying mechanism of disease development.
What is New:
• For the first time, a food-frequency questionnaire that can assess the intake of methione, folate, choline, and betaine has been developed and validated for the use in preschoolers.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35029741</pmid><doi>10.1007/s00431-021-04367-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4335-4867</orcidid></addata></record> |
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| ispartof | European journal of pediatrics, 2022-05, Vol.181 (5), p.1871-1881 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Betaine Child Children Choline Chronic illnesses Diet Diet Records Diet Surveys Dietary intake DNA methylation Energy Intake Epidemiology Folic Acid Food Humans Medicine Medicine & Public Health Methionine Original Article Pediatrics Preschool children Questionnaires Reproducibility Reproducibility of Results Surveys and Questionnaires Validity |
| title | Validation of a food-frequency questionnaire to assess methyl-group donor intake in preschoolers |
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