Mature Naive B Cells Regulate the Outcome of Murine Acute Graft-versus-Host Disease in an IL-10-Independent Manner

•Allogeneic experimental acute graft-versus-host disease (aGVHD) is less severe in in the presence of donor mature I B cells.•aGVHD is as severe in the presence of IL-10-deficient B donor cells as in the total absence of B cells.•Protection from severe aGVHD depends on antigen presentation by donor...

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Veröffentlicht in:	Transplantation and cellular therapy 2022-04, Vol.28 (4), p.181.e1-181.e9
Hauptverfasser:	Galvani, Rômulo Gonçalves, Perobelli, Suelen Martins, Gonçalves-Silva, Triciana, Vianna, Pedro Henrique Oliveira, Cavazzoni, Cecília B., Vale, Andre M., Wanderley, Joao Luiz Mendes, Bonomo, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B cell B-Lymphocytes Bone Marrow Transplantation - adverse effects Follicular helper T cell Graft vs Host Disease - etiology GVHD Interleukin-10 - genetics Mice T cell T-Lymphocytes Transplantation
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