Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy
Tumor cells obtain energy supply from different metabolic pathways to maintain survival. In this study, a tumor acidity-responsive spherical nanoparticle (called as LMGC) was designed by attaching glucose oxidase (GOx) and mineralizing calcium carbonate on the surface of liquid metal nanoparticles t...
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| Veröffentlicht in: | Biomaterials 2022-02, Vol.281, p.121369-121369, Article 121369 |
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| container_title | Biomaterials |
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| creator | Ding, Xing-Lan Liu, Miao-Deng Cheng, Qian Guo, Wen-Hui Niu, Mei-Ting Huang, Qian-Xiao Zeng, Xuan Zhang, Xian-Zheng |
| description | Tumor cells obtain energy supply from different metabolic pathways to maintain survival. In this study, a tumor acidity-responsive spherical nanoparticle (called as LMGC) was designed by attaching glucose oxidase (GOx) and mineralizing calcium carbonate on the surface of liquid metal nanoparticles to integrate the synergistic effect of adenosine triphosphate (ATP) generation inhibition and photothermal therapy (PTT) for enhanced tumor therapy. After GOx catalysis, the process of glycolysis was inhibited, and the increased H2O2 level enhanced the intratumoral oxidative stress. Besides, the gluconic acid production accelerated the degradation of LMGC and promoted Ca2+-mediated mitochondrial dysfunction. The inhibition of glycolysis and mitochondrial metabolism could significantly reduce ATP production and down-regulate heat shock protein (HSP) expression, which would reduce tumor cells heat resistance and improve PTT therapeutic effect. This liquid metal-based ATP inhibition system with enhanced therapeutic effect will find great potential for tumor treatment. |
| doi_str_mv | 10.1016/j.biomaterials.2022.121369 |
| format | Article |
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In this study, a tumor acidity-responsive spherical nanoparticle (called as LMGC) was designed by attaching glucose oxidase (GOx) and mineralizing calcium carbonate on the surface of liquid metal nanoparticles to integrate the synergistic effect of adenosine triphosphate (ATP) generation inhibition and photothermal therapy (PTT) for enhanced tumor therapy. After GOx catalysis, the process of glycolysis was inhibited, and the increased H2O2 level enhanced the intratumoral oxidative stress. Besides, the gluconic acid production accelerated the degradation of LMGC and promoted Ca2+-mediated mitochondrial dysfunction. The inhibition of glycolysis and mitochondrial metabolism could significantly reduce ATP production and down-regulate heat shock protein (HSP) expression, which would reduce tumor cells heat resistance and improve PTT therapeutic effect. This liquid metal-based ATP inhibition system with enhanced therapeutic effect will find great potential for tumor treatment.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2022.121369</identifier><identifier>PMID: 35026671</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adenosine Triphosphate - metabolism ; Cell Line, Tumor ; Glucose Oxidase - metabolism ; Glycolysis ; Humans ; Hydrogen Peroxide - metabolism ; Liquid metal ; Metal Nanoparticles ; Mitochondria - metabolism ; Mitochondrial metabolism ; Nanoparticles ; Neoplasms - drug therapy ; Photothermal Therapy ; Tumor</subject><ispartof>Biomaterials, 2022-02, Vol.281, p.121369-121369, Article 121369</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-ba0c2d67f63c9a978ce9466787eeed9f166437e64f82e33b8af99e8f835520223</citedby><cites>FETCH-LOGICAL-c380t-ba0c2d67f63c9a978ce9466787eeed9f166437e64f82e33b8af99e8f835520223</cites><orcidid>0000-0001-6242-6005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961222000084$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35026671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Xing-Lan</creatorcontrib><creatorcontrib>Liu, Miao-Deng</creatorcontrib><creatorcontrib>Cheng, Qian</creatorcontrib><creatorcontrib>Guo, Wen-Hui</creatorcontrib><creatorcontrib>Niu, Mei-Ting</creatorcontrib><creatorcontrib>Huang, Qian-Xiao</creatorcontrib><creatorcontrib>Zeng, Xuan</creatorcontrib><creatorcontrib>Zhang, Xian-Zheng</creatorcontrib><title>Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Tumor cells obtain energy supply from different metabolic pathways to maintain survival. In this study, a tumor acidity-responsive spherical nanoparticle (called as LMGC) was designed by attaching glucose oxidase (GOx) and mineralizing calcium carbonate on the surface of liquid metal nanoparticles to integrate the synergistic effect of adenosine triphosphate (ATP) generation inhibition and photothermal therapy (PTT) for enhanced tumor therapy. After GOx catalysis, the process of glycolysis was inhibited, and the increased H2O2 level enhanced the intratumoral oxidative stress. Besides, the gluconic acid production accelerated the degradation of LMGC and promoted Ca2+-mediated mitochondrial dysfunction. The inhibition of glycolysis and mitochondrial metabolism could significantly reduce ATP production and down-regulate heat shock protein (HSP) expression, which would reduce tumor cells heat resistance and improve PTT therapeutic effect. This liquid metal-based ATP inhibition system with enhanced therapeutic effect will find great potential for tumor treatment.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Glucose Oxidase - metabolism</subject><subject>Glycolysis</subject><subject>Humans</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Liquid metal</subject><subject>Metal Nanoparticles</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondrial metabolism</subject><subject>Nanoparticles</subject><subject>Neoplasms - drug therapy</subject><subject>Photothermal Therapy</subject><subject>Tumor</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1TAQhS1ERS-FV0ARKza5-CdxYnaohYLUig2sLceZkLly4tR2iu4T8Np1uAWx7MYjS9-ZmTOHkLeM7hll8v1h36GfTIKAxsU9p5zvGWdCqmdkx9qmLWtF6-dkR1nFSyUZPycvYzzQ_KcVf0HORU25lA3bkd-3q0s4rLNN6GfjCod3K_bFBMm4sjMR-mI2s19MSGgdxOIXprH46Y7Wu2PEWJg505i8Hf3cbxv90XbeYZwKnEfscGtdDD4UaZ3yu4w--TRCmDK8VbMcX5GzIZuB14_1gvz4_On75Zfy5tv118uPN6UVLU15IWp5L5tBCquMaloLqspO2gYAejUwKSvRgKyGloMQXWsGpaAdWlHX253EBXl36rsEf7dCTHrCaME5M4Nfo-aSU9qoSomMfjihNvgYAwx6CTiZcNSM6i0IfdD_B6G3AfoURBa_eZyzdhP0_6R_L5-BqxMA2e09QtDRIswWegxgk-49PmXOA7ZNpTM</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Ding, Xing-Lan</creator><creator>Liu, Miao-Deng</creator><creator>Cheng, Qian</creator><creator>Guo, Wen-Hui</creator><creator>Niu, Mei-Ting</creator><creator>Huang, Qian-Xiao</creator><creator>Zeng, Xuan</creator><creator>Zhang, Xian-Zheng</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6242-6005</orcidid></search><sort><creationdate>202202</creationdate><title>Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy</title><author>Ding, Xing-Lan ; Liu, Miao-Deng ; Cheng, Qian ; Guo, Wen-Hui ; Niu, Mei-Ting ; Huang, Qian-Xiao ; Zeng, Xuan ; Zhang, Xian-Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-ba0c2d67f63c9a978ce9466787eeed9f166437e64f82e33b8af99e8f835520223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Glucose Oxidase - metabolism</topic><topic>Glycolysis</topic><topic>Humans</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Liquid metal</topic><topic>Metal Nanoparticles</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondrial metabolism</topic><topic>Nanoparticles</topic><topic>Neoplasms - drug therapy</topic><topic>Photothermal Therapy</topic><topic>Tumor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Xing-Lan</creatorcontrib><creatorcontrib>Liu, Miao-Deng</creatorcontrib><creatorcontrib>Cheng, Qian</creatorcontrib><creatorcontrib>Guo, Wen-Hui</creatorcontrib><creatorcontrib>Niu, Mei-Ting</creatorcontrib><creatorcontrib>Huang, Qian-Xiao</creatorcontrib><creatorcontrib>Zeng, Xuan</creatorcontrib><creatorcontrib>Zhang, Xian-Zheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Xing-Lan</au><au>Liu, Miao-Deng</au><au>Cheng, Qian</au><au>Guo, Wen-Hui</au><au>Niu, Mei-Ting</au><au>Huang, Qian-Xiao</au><au>Zeng, Xuan</au><au>Zhang, Xian-Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2022-02</date><risdate>2022</risdate><volume>281</volume><spage>121369</spage><epage>121369</epage><pages>121369-121369</pages><artnum>121369</artnum><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Tumor cells obtain energy supply from different metabolic pathways to maintain survival. In this study, a tumor acidity-responsive spherical nanoparticle (called as LMGC) was designed by attaching glucose oxidase (GOx) and mineralizing calcium carbonate on the surface of liquid metal nanoparticles to integrate the synergistic effect of adenosine triphosphate (ATP) generation inhibition and photothermal therapy (PTT) for enhanced tumor therapy. After GOx catalysis, the process of glycolysis was inhibited, and the increased H2O2 level enhanced the intratumoral oxidative stress. Besides, the gluconic acid production accelerated the degradation of LMGC and promoted Ca2+-mediated mitochondrial dysfunction. The inhibition of glycolysis and mitochondrial metabolism could significantly reduce ATP production and down-regulate heat shock protein (HSP) expression, which would reduce tumor cells heat resistance and improve PTT therapeutic effect. This liquid metal-based ATP inhibition system with enhanced therapeutic effect will find great potential for tumor treatment.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>35026671</pmid><doi>10.1016/j.biomaterials.2022.121369</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6242-6005</orcidid></addata></record> |
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| subjects | Adenosine Triphosphate - metabolism Cell Line, Tumor Glucose Oxidase - metabolism Glycolysis Humans Hydrogen Peroxide - metabolism Liquid metal Metal Nanoparticles Mitochondria - metabolism Mitochondrial metabolism Nanoparticles Neoplasms - drug therapy Photothermal Therapy Tumor |
| title | Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy |
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