Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer
Cancer stem cells (CSC) are the major obstacle for cancer therapy in clinic. Exosomes are one type of vesicles that containing circular RNA (circRNAs) involved in cell–cell communication. However, the roles of breast CSC (BCSC) exosomes are still unclear, and the purpose of the study was to investig...
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| Veröffentlicht in: | Oncogene 2022-04, Vol.41 (14), p.2012-2025 |
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| container_title | Oncogene |
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| creator | Liu, Yonglei Ma, Li Hua, Fanli Min, Zhihui Zhan, Yanxia Zhang, Wei Yao, Junxia |
| description | Cancer stem cells (CSC) are the major obstacle for cancer therapy in clinic. Exosomes are one type of vesicles that containing circular RNA (circRNAs) involved in cell–cell communication. However, the roles of breast CSC (BCSC) exosomes are still unclear, and the purpose of the study was to investigate breast cancer cell metabolism reprogramming by circRNAs from BCSC exosomes. The circRNA array was performed in the exosomes secreted from spheroids of MDA-231 cells. circCARM1 was higher in BCSC exosomes than it in the parent breast cancer cells. Further investigation demonstrated that BCSC exosomes circCARM1 played an important role in breast cancer cell glycolysis by miR-1252-5p/PFKFB2. In a conclusion, BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression. |
| doi_str_mv | 10.1038/s41388-021-02061-4 |
| format | Article |
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Exosomes are one type of vesicles that containing circular RNA (circRNAs) involved in cell–cell communication. However, the roles of breast CSC (BCSC) exosomes are still unclear, and the purpose of the study was to investigate breast cancer cell metabolism reprogramming by circRNAs from BCSC exosomes. The circRNA array was performed in the exosomes secreted from spheroids of MDA-231 cells. circCARM1 was higher in BCSC exosomes than it in the parent breast cancer cells. Further investigation demonstrated that BCSC exosomes circCARM1 played an important role in breast cancer cell glycolysis by miR-1252-5p/PFKFB2. In a conclusion, BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/s41388-021-02061-4</identifier><identifier>PMID: 35027669</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/31 ; 13/89 ; 14/5 ; 14/63 ; 38/1 ; 38/77 ; 38/90 ; 38/91 ; 42/100 ; 42/109 ; 42/34 ; 42/44 ; 45/61 ; 45/90 ; 631/67/2327 ; 631/67/71 ; 64/60 ; 96/106 ; 96/95 ; Apoptosis ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Cell Biology ; Cell interactions ; Cell Line, Tumor ; Cell Movement - genetics ; Circular RNA ; Exosomes ; Exosomes - genetics ; Exosomes - metabolism ; Female ; Glycolysis ; Human Genetics ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolism ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Oncology ; Phosphofructokinase-2 - metabolism ; Spheroids ; Stem cells</subject><ispartof>Oncogene, 2022-04, Vol.41 (14), p.2012-2025</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022. corrected publication 2022</rights><rights>2022. 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Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yonglei</au><au>Ma, Li</au><au>Hua, Fanli</au><au>Min, Zhihui</au><au>Zhan, Yanxia</au><au>Zhang, Wei</au><au>Yao, Junxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>41</volume><issue>14</issue><spage>2012</spage><epage>2025</epage><pages>2012-2025</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>Cancer stem cells (CSC) are the major obstacle for cancer therapy in clinic. Exosomes are one type of vesicles that containing circular RNA (circRNAs) involved in cell–cell communication. However, the roles of breast CSC (BCSC) exosomes are still unclear, and the purpose of the study was to investigate breast cancer cell metabolism reprogramming by circRNAs from BCSC exosomes. The circRNA array was performed in the exosomes secreted from spheroids of MDA-231 cells. circCARM1 was higher in BCSC exosomes than it in the parent breast cancer cells. Further investigation demonstrated that BCSC exosomes circCARM1 played an important role in breast cancer cell glycolysis by miR-1252-5p/PFKFB2. In a conclusion, BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35027669</pmid><doi>10.1038/s41388-021-02061-4</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1904-0518</orcidid></addata></record> |
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| subjects | 13/31 13/89 14/5 14/63 38/1 38/77 38/90 38/91 42/100 42/109 42/34 42/44 45/61 45/90 631/67/2327 631/67/71 64/60 96/106 96/95 Apoptosis Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Biology Cell interactions Cell Line, Tumor Cell Movement - genetics Circular RNA Exosomes Exosomes - genetics Exosomes - metabolism Female Glycolysis Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metabolism MicroRNAs - genetics MicroRNAs - metabolism Oncology Phosphofructokinase-2 - metabolism Spheroids Stem cells |
| title | Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer |
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