Post-traumatic Osteoarthritis in Rabbits Following Traumatic Injury and Surgical Reconstruction of the Knee
Post-traumatic osteoarthritis (PTOA) of the knee is often attributed to anterior cruciate ligament (ACL) and meniscus injury. The development of PTOA, however, does not seem to depend on whether or not the damaged ACL is reconstructed. There has been a need to develop animal models to study the mech...
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| Veröffentlicht in: | Annals of biomedical engineering 2022-02, Vol.50 (2), p.169-182 |
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| creator | Wei, Feng Powers, Madeleine J. F. Narez, Gerardo E. Dejardin, Loic M. Haut Donahue, Tammy Haut, Roger C. |
| description | Post-traumatic osteoarthritis (PTOA) of the knee is often attributed to anterior cruciate ligament (ACL) and meniscus injury. The development of PTOA, however, does not seem to depend on whether or not the damaged ACL is reconstructed. There has been a need to develop animal models to study the mechanisms of PTOA following reconstruction of a traumatized knee. Eighteen rabbits underwent closed-joint trauma to produce ACL rupture and meniscus damage. Then, for the first time, the traumatized knee was surgically repaired in this animal model. Upon euthanasia at 1-, 3- or 6-month post-trauma, joint stability, cartilage morphology and mechanical properties, as well as histology of the cartilage and subchondral bone were evaluated. Trauma-induced knee injury involved 72% mid-substance ACL rupture, 28% partial ACL tear and 56% concurrent medial meniscal damage. ACL reconstruction effectively restored joint stability by reducing joint laxity to a level similar to that in the contralateral intact knee. Compared to their contralateral controls, reconstructed limbs showed osteoarthritic changes to the cartilage and subchondral bone as early as 1-month post-trauma. The degeneration progressed over time up to 6-month. Overall, the medial compartments had more tissue damage than their corresponding lateral counterparts. Damage patterns to the ACL, the frequency of observed concurrent meniscal injury, and reductions in cartilage integrity and health were consistent with clinical observations of human patients who undergo ACL injury and reconstruction. Thus, we believe the combined closed-joint injury and surgical repair lapine model of PTOA, being first-ever and clinically relevant, shows promise to evaluate well-targeted therapeutics and other interventions for this chronic disease. |
| doi_str_mv | 10.1007/s10439-022-02903-6 |
| format | Article |
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F. ; Narez, Gerardo E. ; Dejardin, Loic M. ; Haut Donahue, Tammy ; Haut, Roger C.</creator><creatorcontrib>Wei, Feng ; Powers, Madeleine J. F. ; Narez, Gerardo E. ; Dejardin, Loic M. ; Haut Donahue, Tammy ; Haut, Roger C.</creatorcontrib><description>Post-traumatic osteoarthritis (PTOA) of the knee is often attributed to anterior cruciate ligament (ACL) and meniscus injury. The development of PTOA, however, does not seem to depend on whether or not the damaged ACL is reconstructed. There has been a need to develop animal models to study the mechanisms of PTOA following reconstruction of a traumatized knee. Eighteen rabbits underwent closed-joint trauma to produce ACL rupture and meniscus damage. Then, for the first time, the traumatized knee was surgically repaired in this animal model. Upon euthanasia at 1-, 3- or 6-month post-trauma, joint stability, cartilage morphology and mechanical properties, as well as histology of the cartilage and subchondral bone were evaluated. Trauma-induced knee injury involved 72% mid-substance ACL rupture, 28% partial ACL tear and 56% concurrent medial meniscal damage. ACL reconstruction effectively restored joint stability by reducing joint laxity to a level similar to that in the contralateral intact knee. Compared to their contralateral controls, reconstructed limbs showed osteoarthritic changes to the cartilage and subchondral bone as early as 1-month post-trauma. The degeneration progressed over time up to 6-month. Overall, the medial compartments had more tissue damage than their corresponding lateral counterparts. Damage patterns to the ACL, the frequency of observed concurrent meniscal injury, and reductions in cartilage integrity and health were consistent with clinical observations of human patients who undergo ACL injury and reconstruction. Thus, we believe the combined closed-joint injury and surgical repair lapine model of PTOA, being first-ever and clinically relevant, shows promise to evaluate well-targeted therapeutics and other interventions for this chronic disease.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-022-02903-6</identifier><identifier>PMID: 35028785</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animal models ; Animals ; Anterior cruciate ligament ; Anterior Cruciate Ligament Injuries - complications ; Anterior Cruciate Ligament Injuries - surgery ; Anterior Cruciate Ligament Reconstruction - adverse effects ; Anterior Cruciate Ligament Reconstruction - methods ; Arthritis ; Biochemistry ; Biological and Medical Physics ; Biomechanical Phenomena ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Biomedicine ; Biophysics ; Cartilage ; Cartilage diseases ; Cartilage, Articular - physiopathology ; Cartilage, Articular - surgery ; Classical Mechanics ; Damage patterns ; Degeneration ; Disease Models, Animal ; Euthanasia ; Histology ; Injury prevention ; Joints (anatomy) ; Knee ; Knee Injuries - complications ; Knee Injuries - surgery ; Knee Joint - physiopathology ; Knee Joint - surgery ; Ligaments ; Mechanical properties ; Meniscus ; Original Article ; Osteoarthritis ; Osteoarthritis, Knee - etiology ; Postoperative Complications - etiology ; Rabbits ; Reconstructive surgery ; Rupture ; Rupturing ; Stability ; Subchondral bone ; Trauma</subject><ispartof>Annals of biomedical engineering, 2022-02, Vol.50 (2), p.169-182</ispartof><rights>The Author(s) under exclusive licence to Biomedical Engineering Society 2022. corrected publication 2022</rights><rights>2022. The Author(s) under exclusive licence to Biomedical Engineering Society.</rights><rights>The Author(s) under exclusive licence to Biomedical Engineering Society 2022. corrected publication 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-ca3890a53638729ffdba51fe869b2ad3f5151aeaa601bf3eb77bcc1c74eda9d83</citedby><cites>FETCH-LOGICAL-c424t-ca3890a53638729ffdba51fe869b2ad3f5151aeaa601bf3eb77bcc1c74eda9d83</cites><orcidid>0000-0002-0749-5582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-022-02903-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-022-02903-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35028785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Feng</creatorcontrib><creatorcontrib>Powers, Madeleine J. F.</creatorcontrib><creatorcontrib>Narez, Gerardo E.</creatorcontrib><creatorcontrib>Dejardin, Loic M.</creatorcontrib><creatorcontrib>Haut Donahue, Tammy</creatorcontrib><creatorcontrib>Haut, Roger C.</creatorcontrib><title>Post-traumatic Osteoarthritis in Rabbits Following Traumatic Injury and Surgical Reconstruction of the Knee</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>Post-traumatic osteoarthritis (PTOA) of the knee is often attributed to anterior cruciate ligament (ACL) and meniscus injury. The development of PTOA, however, does not seem to depend on whether or not the damaged ACL is reconstructed. There has been a need to develop animal models to study the mechanisms of PTOA following reconstruction of a traumatized knee. Eighteen rabbits underwent closed-joint trauma to produce ACL rupture and meniscus damage. Then, for the first time, the traumatized knee was surgically repaired in this animal model. Upon euthanasia at 1-, 3- or 6-month post-trauma, joint stability, cartilage morphology and mechanical properties, as well as histology of the cartilage and subchondral bone were evaluated. Trauma-induced knee injury involved 72% mid-substance ACL rupture, 28% partial ACL tear and 56% concurrent medial meniscal damage. ACL reconstruction effectively restored joint stability by reducing joint laxity to a level similar to that in the contralateral intact knee. Compared to their contralateral controls, reconstructed limbs showed osteoarthritic changes to the cartilage and subchondral bone as early as 1-month post-trauma. The degeneration progressed over time up to 6-month. Overall, the medial compartments had more tissue damage than their corresponding lateral counterparts. Damage patterns to the ACL, the frequency of observed concurrent meniscal injury, and reductions in cartilage integrity and health were consistent with clinical observations of human patients who undergo ACL injury and reconstruction. Thus, we believe the combined closed-joint injury and surgical repair lapine model of PTOA, being first-ever and clinically relevant, shows promise to evaluate well-targeted therapeutics and other interventions for this chronic disease.</description><subject>Animal models</subject><subject>Animals</subject><subject>Anterior cruciate ligament</subject><subject>Anterior Cruciate Ligament Injuries - complications</subject><subject>Anterior Cruciate Ligament Injuries - surgery</subject><subject>Anterior Cruciate Ligament Reconstruction - adverse effects</subject><subject>Anterior Cruciate Ligament Reconstruction - methods</subject><subject>Arthritis</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Cartilage</subject><subject>Cartilage diseases</subject><subject>Cartilage, Articular - physiopathology</subject><subject>Cartilage, Articular - surgery</subject><subject>Classical Mechanics</subject><subject>Damage patterns</subject><subject>Degeneration</subject><subject>Disease Models, Animal</subject><subject>Euthanasia</subject><subject>Histology</subject><subject>Injury prevention</subject><subject>Joints (anatomy)</subject><subject>Knee</subject><subject>Knee Injuries - complications</subject><subject>Knee Injuries - surgery</subject><subject>Knee Joint - physiopathology</subject><subject>Knee Joint - surgery</subject><subject>Ligaments</subject><subject>Mechanical properties</subject><subject>Meniscus</subject><subject>Original Article</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - etiology</subject><subject>Postoperative Complications - etiology</subject><subject>Rabbits</subject><subject>Reconstructive surgery</subject><subject>Rupture</subject><subject>Rupturing</subject><subject>Stability</subject><subject>Subchondral bone</subject><subject>Trauma</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9P3DAQxa0KVLbQL9ADssSll4D_xI59rBDboiKBgJ6tieMsXrI2tR0hvj2mS6nUA4fRHOY3b0bvIfSFkmNKSHeSKWm5bghjtTThjfyAFlR0vNFSyR20IESTRmrZ7qFPOa8JoVRx8RHtcUGY6pRYoPurmEtTEswbKN7iy1xchFTuki8-Yx_wNfS9Lxkv4zTFRx9W-PaNPg_rOT1hCAO-mdPKW5jwtbMx5JJmW3wMOI643Dn8Mzh3gHZHmLL7_Nr30a_l2e3pj-bi8vv56beLxrasLY0FrjQBwSVXHdPjOPQg6OiU1D2DgY-CCgoOQBLaj9z1XddbS23XugH0oPg--rrVfUjx9-xyMRufrZsmCC7O2TDJqn1KiraiR_-h6zinUL97oVrChaC0UmxL2RRzTm40D8lvID0ZSsxLFGYbhalRmD9RGFmXDl-l537jhreVv95XgG-BXEdh5dK_2-_IPgPVR5XE</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Wei, Feng</creator><creator>Powers, Madeleine J. 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F.</au><au>Narez, Gerardo E.</au><au>Dejardin, Loic M.</au><au>Haut Donahue, Tammy</au><au>Haut, Roger C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-traumatic Osteoarthritis in Rabbits Following Traumatic Injury and Surgical Reconstruction of the Knee</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>50</volume><issue>2</issue><spage>169</spage><epage>182</epage><pages>169-182</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>Post-traumatic osteoarthritis (PTOA) of the knee is often attributed to anterior cruciate ligament (ACL) and meniscus injury. The development of PTOA, however, does not seem to depend on whether or not the damaged ACL is reconstructed. There has been a need to develop animal models to study the mechanisms of PTOA following reconstruction of a traumatized knee. Eighteen rabbits underwent closed-joint trauma to produce ACL rupture and meniscus damage. Then, for the first time, the traumatized knee was surgically repaired in this animal model. Upon euthanasia at 1-, 3- or 6-month post-trauma, joint stability, cartilage morphology and mechanical properties, as well as histology of the cartilage and subchondral bone were evaluated. Trauma-induced knee injury involved 72% mid-substance ACL rupture, 28% partial ACL tear and 56% concurrent medial meniscal damage. ACL reconstruction effectively restored joint stability by reducing joint laxity to a level similar to that in the contralateral intact knee. Compared to their contralateral controls, reconstructed limbs showed osteoarthritic changes to the cartilage and subchondral bone as early as 1-month post-trauma. The degeneration progressed over time up to 6-month. Overall, the medial compartments had more tissue damage than their corresponding lateral counterparts. Damage patterns to the ACL, the frequency of observed concurrent meniscal injury, and reductions in cartilage integrity and health were consistent with clinical observations of human patients who undergo ACL injury and reconstruction. Thus, we believe the combined closed-joint injury and surgical repair lapine model of PTOA, being first-ever and clinically relevant, shows promise to evaluate well-targeted therapeutics and other interventions for this chronic disease.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35028785</pmid><doi>10.1007/s10439-022-02903-6</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-0749-5582</orcidid></addata></record> |
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| subjects | Animal models Animals Anterior cruciate ligament Anterior Cruciate Ligament Injuries - complications Anterior Cruciate Ligament Injuries - surgery Anterior Cruciate Ligament Reconstruction - adverse effects Anterior Cruciate Ligament Reconstruction - methods Arthritis Biochemistry Biological and Medical Physics Biomechanical Phenomena Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical materials Biomedicine Biophysics Cartilage Cartilage diseases Cartilage, Articular - physiopathology Cartilage, Articular - surgery Classical Mechanics Damage patterns Degeneration Disease Models, Animal Euthanasia Histology Injury prevention Joints (anatomy) Knee Knee Injuries - complications Knee Injuries - surgery Knee Joint - physiopathology Knee Joint - surgery Ligaments Mechanical properties Meniscus Original Article Osteoarthritis Osteoarthritis, Knee - etiology Postoperative Complications - etiology Rabbits Reconstructive surgery Rupture Rupturing Stability Subchondral bone Trauma |
| title | Post-traumatic Osteoarthritis in Rabbits Following Traumatic Injury and Surgical Reconstruction of the Knee |
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