Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms
Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular‐related diseases, ginseng is still the focus...
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| Veröffentlicht in: | Phytotherapy research 2022-02, Vol.36 (2), p.857-872 |
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| container_title | Phytotherapy research |
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| creator | Zhang, He Hu, Cheng Xue, Jiaojiao Jin, Di Tian, Lulu Zhao, Daqing Li, Xiangyan Qi, Wenxiu |
| description | Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular‐related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular‐related diseases, including cardiac‐cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted. We systematically teased out the relationship between ginseng and vascular dysfunction, which could provide a basis for the clinical application of ginseng in the future. |
| doi_str_mv | 10.1002/ptr.7369 |
| format | Article |
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Although a large number of studies have reported the therapeutic effects of natural compounds on vascular‐related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular‐related diseases, including cardiac‐cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted. 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Although a large number of studies have reported the therapeutic effects of natural compounds on vascular‐related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular‐related diseases, including cardiac‐cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted. We systematically teased out the relationship between ginseng and vascular dysfunction, which could provide a basis for the clinical application of ginseng in the future.</description><subject>Angiogenesis</subject><subject>Cancer</subject><subject>Cerebrovascular diseases</subject><subject>Chemical compounds</subject><subject>Complications</subject><subject>Coronary artery disease</subject><subject>Diabetes mellitus</subject><subject>Ginseng</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Molecular modelling</subject><subject>Panax</subject><subject>Pharmacology</subject><subject>Signal Transduction</subject><subject>Vascular diseases</subject><subject>vascular dysfunction</subject><subject>vascular endothelial cells</subject><subject>vascular smooth muscle cells</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFq3DAQQEVoSDabQr8gCHrpxclItmWrt2Vpk0AgIWygh4KRpVGiYMuuZO-yf19vd5tCoKc5zJvH8Aj5xOCSAfCrfgiXRSrkEZkxkDJheZF-IDOQOUsyVv44JWcxvgKA5JCdkNM0By5KUczIz2vnI_pn6jxdq6jHRgVqttGOXg-u81_pggZcO9zQztLhBYPqcRycpn03oB-caiJV3tC2a3B_3aJ-Ud7FNp6TYzvt8eNhzsnT92-r5U1yd399u1zcJTrNpm-tza1VPDfIDaIxJrc8Y0qwrDaWl0KwGoXSNS9qkaVagFRSljtW1liqLJ2TL3tvH7pfI8ahal3U2DTKYzfGigsOUBRFDhP6-R362o3BT9_tKMmAgSj-CXXoYgxoqz64VoVtxaDaFa-m4tWu-IReHIRj3aJ5A_8mnoBkD2xcg9v_iqqH1eMf4W_fL4v5</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Zhang, He</creator><creator>Hu, Cheng</creator><creator>Xue, Jiaojiao</creator><creator>Jin, Di</creator><creator>Tian, Lulu</creator><creator>Zhao, Daqing</creator><creator>Li, Xiangyan</creator><creator>Qi, Wenxiu</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6780-6314</orcidid><orcidid>https://orcid.org/0000-0001-5034-0458</orcidid></search><sort><creationdate>202202</creationdate><title>Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms</title><author>Zhang, He ; Hu, Cheng ; Xue, Jiaojiao ; Jin, Di ; Tian, Lulu ; Zhao, Daqing ; Li, Xiangyan ; Qi, Wenxiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3499-ff5ffa25de2deeddd5f241a614bdf28661be6acb27b643c609a9982dee9be8a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Cancer</topic><topic>Cerebrovascular diseases</topic><topic>Chemical compounds</topic><topic>Complications</topic><topic>Coronary artery disease</topic><topic>Diabetes mellitus</topic><topic>Ginseng</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Molecular modelling</topic><topic>Panax</topic><topic>Pharmacology</topic><topic>Signal Transduction</topic><topic>Vascular diseases</topic><topic>vascular dysfunction</topic><topic>vascular endothelial cells</topic><topic>vascular smooth muscle cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Hu, Cheng</creatorcontrib><creatorcontrib>Xue, Jiaojiao</creatorcontrib><creatorcontrib>Jin, Di</creatorcontrib><creatorcontrib>Tian, Lulu</creatorcontrib><creatorcontrib>Zhao, Daqing</creatorcontrib><creatorcontrib>Li, Xiangyan</creatorcontrib><creatorcontrib>Qi, Wenxiu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, He</au><au>Hu, Cheng</au><au>Xue, Jiaojiao</au><au>Jin, Di</au><au>Tian, Lulu</au><au>Zhao, Daqing</au><au>Li, Xiangyan</au><au>Qi, Wenxiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2022-02</date><risdate>2022</risdate><volume>36</volume><issue>2</issue><spage>857</spage><epage>872</epage><pages>857-872</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular‐related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular‐related diseases, including cardiac‐cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted. 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| subjects | Angiogenesis Cancer Cerebrovascular diseases Chemical compounds Complications Coronary artery disease Diabetes mellitus Ginseng Heart diseases Humans Hypertension Hypertension - drug therapy Metabolic disorders Metabolic syndrome Molecular modelling Panax Pharmacology Signal Transduction Vascular diseases vascular dysfunction vascular endothelial cells vascular smooth muscle cells |
| title | Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms |
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