Astragaloside IV pre-treatment attenuates PM2.5-induced lung injury in rats: Impact on autophagy, apoptosis and inflammation

•Autophagy flux inhibition is a critical mechanism of PM2.5-induced lung toxicity in rats.•PM2.5 triggered pulmonary inflammation by tipping the balance between autophagy and apoptosis.•Astragaloside IV increased autophagic flux and inhibited apoptosis and inflammation by activation of the AMPK/mTOR...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Phytomedicine (Stuttgart) 2022-02, Vol.96, p.153912-153912, Article 153912
Hauptverfasser:	Wang, Zhenxing, Wu, Yongcan, Pei, Caixia, Wang, Mingjie, Wang, Xiaomin, Shi, Shihua, Huang, Demei, Wang, Yilan, Li, Shuiqin, Xiao, Wei, He, Yacong, Wang, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases Animals Apoptosis Astragaloside iv Autophagic flux Autophagy Inflammation - drug therapy Lung Injury - chemically induced Lung Injury - drug therapy Lung toxicity Particulate Matter - toxicity Pm2.5 Rats Saponins Triterpenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!