The health status: the ignored risk factor in dementia incidence. NEDICES cohort
Background The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health...
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| Veröffentlicht in: | Aging clinical and experimental research 2022-06, Vol.34 (6), p.1275-1283 |
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| creator | Bermejo-Pareja, Félix Gómez de la Cámara, Agustín del Ser, Teodoro Contador, Israel Llamas-Velasco, Sara López-Arrieta, Jesús María Martín-Arriscado, Cristina Hernández-Gallego, Jesús Vega, Saturio Benito-León, Julián |
| description | Background
The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health status is rarely considered as a single RF.
Aim
To analyse whether the health status and the self-perceived health (SPH) could be RF for dementia and AD and to discuss its biological basis.
Methods
We analysed different objective health measures and SPH as RF for dementia and AD incidence in 4569 participants of the NEDICES cohort by means of Cox-regression models. The mean follow-up period was 3.2 (range: 0.03–6.6) years.
Results
Ageing, low education, history of stroke, and “poor” SPH were the main RF for dementia and AD incidence, whereas physical activity was protective. “Poor” SPH had a hazard ratio = 1.66 (95% CI 1.17–2.46;
p
= 0.012) after controlling for different confounders.
Discussion
According to data from NEDICES cohort, SPH is a better predictor of dementia and AD than other more objective health status proxies. SPH should be considered a holistic and biologically rooted indicator of health status, which can predict future development of dementia and AD in older adults.
Conclusions
Our data indicate that it is worthwhile to include the SPH status as a RF in the studies of dementia and AD incidence and to explore the effect of its improvement in the evolution of this incidence. |
| doi_str_mv | 10.1007/s40520-021-02045-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2619543765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2671455391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-d86ffbd397b039cfd16722100b8ae54a67a11422f53d34f253aee77a171d3c9f3</originalsourceid><addsrcrecordid>eNp9kEtPAyEUhYnR2Pr4Ay4MiRs3U3kMQ8edqVWbNGpiXRMKl3ZqO1OBWfjvRVsfceGCcO_huwc4CJ1Q0qOEyIuQE8FIRhhNi-QiIzuoS2WS-pyWu7_qDjoIYUFITlOzjzpcECZIKbrocTIHPAe9jHMcoo5tuMQxSdWsbjxY7Kvwgp02sfG4qrGFFdSx0qk2lYXaQA_fD69Hg-ETNs288fEI7Tm9DHC83Q_R881wMrjLxg-3o8HVODOciJjZfuHc1PJSTgkvjbO0kIylb037GkSuC6kpzRlzglueOya4BpBJlNRyUzp-iM43vmvfvLYQolpVwcByqWto2qBYQUuRc1mIhJ79QRdN6-v0ukRJmgvBS5ootqGMb0Lw4NTaVyvt3xQl6iNvtclbpbzVZ96KpKHTrXU7XYH9HvkKOAF8A4R0VM_A_9z9j-07-ayIjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2671455391</pqid></control><display><type>article</type><title>The health status: the ignored risk factor in dementia incidence. NEDICES cohort</title><source>Springer Nature - Complete Springer Journals</source><creator>Bermejo-Pareja, Félix ; Gómez de la Cámara, Agustín ; del Ser, Teodoro ; Contador, Israel ; Llamas-Velasco, Sara ; López-Arrieta, Jesús María ; Martín-Arriscado, Cristina ; Hernández-Gallego, Jesús ; Vega, Saturio ; Benito-León, Julián</creator><creatorcontrib>Bermejo-Pareja, Félix ; Gómez de la Cámara, Agustín ; del Ser, Teodoro ; Contador, Israel ; Llamas-Velasco, Sara ; López-Arrieta, Jesús María ; Martín-Arriscado, Cristina ; Hernández-Gallego, Jesús ; Vega, Saturio ; Benito-León, Julián</creatorcontrib><description>Background
The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health status is rarely considered as a single RF.
Aim
To analyse whether the health status and the self-perceived health (SPH) could be RF for dementia and AD and to discuss its biological basis.
Methods
We analysed different objective health measures and SPH as RF for dementia and AD incidence in 4569 participants of the NEDICES cohort by means of Cox-regression models. The mean follow-up period was 3.2 (range: 0.03–6.6) years.
Results
Ageing, low education, history of stroke, and “poor” SPH were the main RF for dementia and AD incidence, whereas physical activity was protective. “Poor” SPH had a hazard ratio = 1.66 (95% CI 1.17–2.46;
p
= 0.012) after controlling for different confounders.
Discussion
According to data from NEDICES cohort, SPH is a better predictor of dementia and AD than other more objective health status proxies. SPH should be considered a holistic and biologically rooted indicator of health status, which can predict future development of dementia and AD in older adults.
Conclusions
Our data indicate that it is worthwhile to include the SPH status as a RF in the studies of dementia and AD incidence and to explore the effect of its improvement in the evolution of this incidence.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-021-02045-0</identifier><identifier>PMID: 35025095</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Alzheimer's disease ; Blood pressure ; Chronic illnesses ; Dementia ; Education ; Exercise ; Geriatrics/Gerontology ; Hypertension ; Lifestyles ; Medicine ; Medicine & Public Health ; Mortality ; Older people ; Original Article ; Primary care ; Questionnaires ; Risk factors ; Stroke</subject><ispartof>Aging clinical and experimental research, 2022-06, Vol.34 (6), p.1275-1283</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-d86ffbd397b039cfd16722100b8ae54a67a11422f53d34f253aee77a171d3c9f3</citedby><cites>FETCH-LOGICAL-c305t-d86ffbd397b039cfd16722100b8ae54a67a11422f53d34f253aee77a171d3c9f3</cites><orcidid>0000-0002-9174-2610</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-021-02045-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-021-02045-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35025095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bermejo-Pareja, Félix</creatorcontrib><creatorcontrib>Gómez de la Cámara, Agustín</creatorcontrib><creatorcontrib>del Ser, Teodoro</creatorcontrib><creatorcontrib>Contador, Israel</creatorcontrib><creatorcontrib>Llamas-Velasco, Sara</creatorcontrib><creatorcontrib>López-Arrieta, Jesús María</creatorcontrib><creatorcontrib>Martín-Arriscado, Cristina</creatorcontrib><creatorcontrib>Hernández-Gallego, Jesús</creatorcontrib><creatorcontrib>Vega, Saturio</creatorcontrib><creatorcontrib>Benito-León, Julián</creatorcontrib><title>The health status: the ignored risk factor in dementia incidence. NEDICES cohort</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health status is rarely considered as a single RF.
Aim
To analyse whether the health status and the self-perceived health (SPH) could be RF for dementia and AD and to discuss its biological basis.
Methods
We analysed different objective health measures and SPH as RF for dementia and AD incidence in 4569 participants of the NEDICES cohort by means of Cox-regression models. The mean follow-up period was 3.2 (range: 0.03–6.6) years.
Results
Ageing, low education, history of stroke, and “poor” SPH were the main RF for dementia and AD incidence, whereas physical activity was protective. “Poor” SPH had a hazard ratio = 1.66 (95% CI 1.17–2.46;
p
= 0.012) after controlling for different confounders.
Discussion
According to data from NEDICES cohort, SPH is a better predictor of dementia and AD than other more objective health status proxies. SPH should be considered a holistic and biologically rooted indicator of health status, which can predict future development of dementia and AD in older adults.
Conclusions
Our data indicate that it is worthwhile to include the SPH status as a RF in the studies of dementia and AD incidence and to explore the effect of its improvement in the evolution of this incidence.</description><subject>Alzheimer's disease</subject><subject>Blood pressure</subject><subject>Chronic illnesses</subject><subject>Dementia</subject><subject>Education</subject><subject>Exercise</subject><subject>Geriatrics/Gerontology</subject><subject>Hypertension</subject><subject>Lifestyles</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Older people</subject><subject>Original Article</subject><subject>Primary care</subject><subject>Questionnaires</subject><subject>Risk factors</subject><subject>Stroke</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtPAyEUhYnR2Pr4Ay4MiRs3U3kMQ8edqVWbNGpiXRMKl3ZqO1OBWfjvRVsfceGCcO_huwc4CJ1Q0qOEyIuQE8FIRhhNi-QiIzuoS2WS-pyWu7_qDjoIYUFITlOzjzpcECZIKbrocTIHPAe9jHMcoo5tuMQxSdWsbjxY7Kvwgp02sfG4qrGFFdSx0qk2lYXaQA_fD69Hg-ETNs288fEI7Tm9DHC83Q_R881wMrjLxg-3o8HVODOciJjZfuHc1PJSTgkvjbO0kIylb037GkSuC6kpzRlzglueOya4BpBJlNRyUzp-iM43vmvfvLYQolpVwcByqWto2qBYQUuRc1mIhJ79QRdN6-v0ukRJmgvBS5ootqGMb0Lw4NTaVyvt3xQl6iNvtclbpbzVZ96KpKHTrXU7XYH9HvkKOAF8A4R0VM_A_9z9j-07-ayIjw</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Bermejo-Pareja, Félix</creator><creator>Gómez de la Cámara, Agustín</creator><creator>del Ser, Teodoro</creator><creator>Contador, Israel</creator><creator>Llamas-Velasco, Sara</creator><creator>López-Arrieta, Jesús María</creator><creator>Martín-Arriscado, Cristina</creator><creator>Hernández-Gallego, Jesús</creator><creator>Vega, Saturio</creator><creator>Benito-León, Julián</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9174-2610</orcidid></search><sort><creationdate>20220601</creationdate><title>The health status: the ignored risk factor in dementia incidence. NEDICES cohort</title><author>Bermejo-Pareja, Félix ; Gómez de la Cámara, Agustín ; del Ser, Teodoro ; Contador, Israel ; Llamas-Velasco, Sara ; López-Arrieta, Jesús María ; Martín-Arriscado, Cristina ; Hernández-Gallego, Jesús ; Vega, Saturio ; Benito-León, Julián</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-d86ffbd397b039cfd16722100b8ae54a67a11422f53d34f253aee77a171d3c9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Blood pressure</topic><topic>Chronic illnesses</topic><topic>Dementia</topic><topic>Education</topic><topic>Exercise</topic><topic>Geriatrics/Gerontology</topic><topic>Hypertension</topic><topic>Lifestyles</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Older people</topic><topic>Original Article</topic><topic>Primary care</topic><topic>Questionnaires</topic><topic>Risk factors</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bermejo-Pareja, Félix</creatorcontrib><creatorcontrib>Gómez de la Cámara, Agustín</creatorcontrib><creatorcontrib>del Ser, Teodoro</creatorcontrib><creatorcontrib>Contador, Israel</creatorcontrib><creatorcontrib>Llamas-Velasco, Sara</creatorcontrib><creatorcontrib>López-Arrieta, Jesús María</creatorcontrib><creatorcontrib>Martín-Arriscado, Cristina</creatorcontrib><creatorcontrib>Hernández-Gallego, Jesús</creatorcontrib><creatorcontrib>Vega, Saturio</creatorcontrib><creatorcontrib>Benito-León, Julián</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bermejo-Pareja, Félix</au><au>Gómez de la Cámara, Agustín</au><au>del Ser, Teodoro</au><au>Contador, Israel</au><au>Llamas-Velasco, Sara</au><au>López-Arrieta, Jesús María</au><au>Martín-Arriscado, Cristina</au><au>Hernández-Gallego, Jesús</au><au>Vega, Saturio</au><au>Benito-León, Julián</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The health status: the ignored risk factor in dementia incidence. NEDICES cohort</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>34</volume><issue>6</issue><spage>1275</spage><epage>1283</epage><pages>1275-1283</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health status is rarely considered as a single RF.
Aim
To analyse whether the health status and the self-perceived health (SPH) could be RF for dementia and AD and to discuss its biological basis.
Methods
We analysed different objective health measures and SPH as RF for dementia and AD incidence in 4569 participants of the NEDICES cohort by means of Cox-regression models. The mean follow-up period was 3.2 (range: 0.03–6.6) years.
Results
Ageing, low education, history of stroke, and “poor” SPH were the main RF for dementia and AD incidence, whereas physical activity was protective. “Poor” SPH had a hazard ratio = 1.66 (95% CI 1.17–2.46;
p
= 0.012) after controlling for different confounders.
Discussion
According to data from NEDICES cohort, SPH is a better predictor of dementia and AD than other more objective health status proxies. SPH should be considered a holistic and biologically rooted indicator of health status, which can predict future development of dementia and AD in older adults.
Conclusions
Our data indicate that it is worthwhile to include the SPH status as a RF in the studies of dementia and AD incidence and to explore the effect of its improvement in the evolution of this incidence.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35025095</pmid><doi>10.1007/s40520-021-02045-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9174-2610</orcidid></addata></record> |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Alzheimer's disease Blood pressure Chronic illnesses Dementia Education Exercise Geriatrics/Gerontology Hypertension Lifestyles Medicine Medicine & Public Health Mortality Older people Original Article Primary care Questionnaires Risk factors Stroke |
| title | The health status: the ignored risk factor in dementia incidence. NEDICES cohort |
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