NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced immunotherapy. RNA sequencing (RNA-seq), TCGA data analysis, flow cyt...

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Veröffentlicht in:	Clinical cancer research 2022-04, Vol.28 (7), p.1460-1473
Hauptverfasser:	Otani, Yoshihiro, Yoo, Ji Young, Lewis, Cole T, Chao, Samantha, Swanner, Jessica, Shimizu, Toshihiko, Kang, Jin Muk, Murphy, Sara A, Rivera-Caraballo, Kimberly, Hong, Bangxing, Glorioso, Joseph C, Nakashima, Hiroshi, Lawler, Sean E, Banasavadi-Siddegowda, Yeshavanth, Heiss, John D, Yan, Yuanqing, Pei, Guangsheng, Caligiuri, Michael A, Zhao, Zhongming, Chiocca, E Antonio, Yu, Jianhua, Kaur, Balveen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Glioblastoma - pathology Humans Immunotherapy Mice Myeloid-Derived Suppressor Cells - metabolism Neoplasm Recurrence, Local - therapy Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Simplexvirus Tumor Microenvironment Xenograft Model Antitumor Assays
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