Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of α‑Synuclein Autoantibodies in Human Plasma

The misfolding and subsequent aggregation of amyloidogenic proteins is a classic pathological hallmark of neurodegenerative diseases. Aggregates of the α-synuclein protein (αS) are implicated in Parkinson’s disease (PD) pathogenesis, and naturally occurring autoantibodies to these aggregates are pro...

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Veröffentlicht in:	Bioconjugate chemistry 2022-02, Vol.33 (2), p.301-310
Hauptverfasser:	Ge, Peng, Yang, Mu, Bouchard, Jacob L, Dzamko, Nicolas, Lewis, Simon J. G, Halliday, Glenda M, Doran, Todd M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates alpha-Synuclein - chemistry Amyloidogenesis Amyloidogenic Proteins Antigens Autoantibodies Binding Biomarkers Blood plasma Enzyme-linked immunosorbent assay Humans IgG antibody Immunoassay Immunoassays Immunoglobulin G Microspheres Monomers Movement disorders Neurodegenerative diseases Nucleation Oligomers Parkinson Disease - diagnosis Parkinson's disease Pathogenesis Polyethylene glycol Polyethylene Glycols Protein folding Proteins Solid phases Symptomology Synuclein
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