Ultra-High Signal Detection of Human Embryonic Stem Cells Driven by Two-Dimensional Materials

Ultra-High Signal Detection of Human Embryonic Stem Cells Driven by Two-Dimensional Materials

We observed a unique bioelectric signal of human embryonic stem cells using direct current–voltage measurements facilitated by few-layered 2D-MoS2 sheets. A 1.828 mA cell signal was achieved (2 orders of magnitude higher than previous electrical-based detection methods) as well as multiple cell read...

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Veröffentlicht in:ACS applied bio materials 2018-08, Vol.1 (2), p.210-215
Hauptverfasser: Chan, Sophia S. Y, Tan, Yaw Sing, Wu, Kan-Xing, Cheung, Christine, Loke, Desmond K
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creator Chan, Sophia S. Y
Tan, Yaw Sing
Wu, Kan-Xing
Cheung, Christine
Loke, Desmond K
description We observed a unique bioelectric signal of human embryonic stem cells using direct current–voltage measurements facilitated by few-layered 2D-MoS2 sheets. A 1.828 mA cell signal was achieved (2 orders of magnitude higher than previous electrical-based detection methods) as well as multiple cell reading cycles demonstrating I ∼ 1.9 mA. Native stem cell proliferation, viability, and pluripotency were preserved. Molecular dynamics simulations elucidated the origin of the 2D-MoS2 sheet-assisted increase in current flow. This paves the way for the development of a broadly applicable, fast, and damage-free stem cell detection method capable of identifying pluripotency with virtually any complementary-metal-oxide-semiconductor circuits.
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