NMDA mediates disruption of blood-brain barrier permeability via Rho/ROCK signaling pathway

Glutamate can activate the N-methyl-D-aspartatic acid (NMDA) receptor (NMDAR), damage brain microvascular endothelial cells, and disturb the intercellular tight junctions (TJs). These result in changes in the permeability of the blood brain barrier (BBB). In neurons, the activation of Rho/ROCK signa...

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Veröffentlicht in:	Neurochemistry international 2022-03, Vol.154, p.105278-105278, Article 105278
Hauptverfasser:	Yu, Yachun, Wu, Yu, Wei, Junxiang, Huang, Fang, Mao, Fengping, Nong, Weidong, Cao, Xiaoli, Huang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood brain barrier Blood-Brain Barrier - metabolism Endothelial Cells - metabolism Human brain microvascular endothelial cells Humans N-Methyl-D-aspartatic acid N-Methylaspartate - metabolism Permeability rho-Associated Kinases - metabolism Rho/ROCK signaling Pathway Signal Transduction Tight junction protein
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