Safety and Efficacy of Tenecteplase in Older Patients With Large Vessel Occlusion: A Pooled Analysis of the EXTEND-IA TNK Trials

Detailed study of tenecteplase (TNK) in patients older than 80 years is limited. The objective of our study was to assess the safety and efficacy of TNK at 0.25 and 0.40 mg/kg doses in patients older than 80 years with large vessel occlusion. We performed a pooled analysis of the EXTEND-IA TNK rando...

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Veröffentlicht in:	Neurology 2022-03, Vol.98 (12), p.e1292-e1301
Hauptverfasser:	Yogendrakumar, Vignan, Churilov, Leonid, Mitchell, Peter J., Kleinig, Timothy J., Yassi, Nawaf, Thijs, Vincent, Wu, Teddy Y., Shah, Darshan G., Ng, Felix C., Dewey, Helen M., Wijeratne, Tissa, Yan, Bernard, Desmond, Patricia M., Parsons, Mark W., Donnan, Geoffrey Alan, Davis, Stephen M., Campbell, Bruce C.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Brain Ischemia - drug therapy Fibrinolytic Agents - adverse effects Humans Stroke - therapy Tenecteplase - therapeutic use Tissue Plasminogen Activator - adverse effects Treatment Outcome
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