Monitoring dynamic pre-crystallization aggregation processes in solution by VT-DOSY-NMR spectroscopy

Monitoring dynamic pre-crystallization aggregation processes in solution by VT-DOSY-NMR spectroscopy

Equimolar mixtures of pyridine (Py) with -halotetrafluoropyridine (BrTFP and ITFP) were investigated by VT-diffusion NMR experiments. The formation of a halogen-bond-stabilized ITFP Py complex was detected upon cooling a solution in methylcyclohexane- to 260 K; this allows monitoring a halogen-bond-...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-03, Vol.58 (21), p.3465-3468
Hauptverfasser: Mix, Andreas, Lamm, Jan-Hendrik, Schwabedissen, Jan, Gebel, Erich, Stammler, Hans-Georg, Mitzel, Norbert W
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Sprache:eng
Schlagworte:
Agglomeration
Crystallization
Methylcyclohexane
Monitoring
NMR spectroscopy
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container_end_page 3468
container_issue 21
container_start_page 3465
container_title Chemical communications (Cambridge, England)
container_volume 58
creator Mix, Andreas
Lamm, Jan-Hendrik
Schwabedissen, Jan
Gebel, Erich
Stammler, Hans-Georg
Mitzel, Norbert W
description Equimolar mixtures of pyridine (Py) with -halotetrafluoropyridine (BrTFP and ITFP) were investigated by VT-diffusion NMR experiments. The formation of a halogen-bond-stabilized ITFP Py complex was detected upon cooling a solution in methylcyclohexane- to 260 K; this allows monitoring a halogen-bond-driven aggregation process preceding crystallization in solution.
doi_str_mv 10.1039/d1cc05925d
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Agglomeration
Crystallization
Methylcyclohexane
Monitoring
NMR spectroscopy
title Monitoring dynamic pre-crystallization aggregation processes in solution by VT-DOSY-NMR spectroscopy
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