Mollugin induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in hepatoma cells

Mollugin has been proven to have anti-tumor activity. However, its potential anti-tumor mechanism remains to be fully elaborated. Herein, we investigated the growth inhibition of HepG2 cells, as well as the anti-tumor effect of mollugin and its molecular mechanism on H22-tumor bearing mice. In vitro...

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Veröffentlicht in:	Chemico-biological interactions 2022-02, Vol.353, p.109805-109805, Article 109805
Hauptverfasser:	Ke, Xin-ge, Xiong, Yi-yi, Yu, Bing, Yuan, Chong, Chen, Peng-yu, Yang, Yan-fang, Wu, He-zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - chemistry Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell cycle arrest Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Cyclin A2 - genetics Cyclin A2 - metabolism Cyclin-Dependent Kinase 2 - genetics Cyclin-Dependent Kinase 2 - metabolism DNA damage DNA Damage - drug effects Hep G2 Cells Humans Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Mollugin Oxidative Stress - drug effects Pyrans - chemistry Pyrans - pharmacology Pyrans - therapeutic use Reactive Oxygen Species - metabolism ROS Up-Regulation - drug effects
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