Self‐Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Toward Revealing the Synergy of Chemo‐ and Noninvasive Photothermal Therapy against Colon Microtumor
Three‐dimensional (3D) tumor cell culture offers a more tissue‐recapitulating model in cancer treatment evaluation. However, conventional models based on cell‐substrate adhesion deprivation are still of insufficient real tumor mimic. In this work, a novel method is proposed for inducing multicellula...
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| Veröffentlicht in: | Macromolecular bioscience 2022-04, Vol.22 (4), p.e2100498-n/a |
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| creator | Zhang, Yi Guo, Zhao‐bin Nie, Yu‐min Feng, Guan‐ping Deng, Man‐jiao Hu, Yi‐min Zhang, Hui‐jie Zhao, Yin‐yi Feng, Yi‐wei Yu, Ting‐ting Hu, Ke |
| description | Three‐dimensional (3D) tumor cell culture offers a more tissue‐recapitulating model in cancer treatment evaluation. However, conventional models based on cell‐substrate adhesion deprivation are still of insufficient real tumor mimic. In this work, a novel method is proposed for inducing multicellular spheroids (MCSs) formation based on hydrogel with tunable microenvironmental properties. Colon tumor cells DLD1 cultured on hydrogel substrate with proper physical stimulation form MCSs via self‐organization. Chemotherapy based on clinical drug and far‐infrared photothermal therapy is evaluated with DLD1 MCSs obtained by this method. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and it is believed this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine.
A novel method for inducing multicellular spheroids (MCSs) formation is proposed based on hydrogel with tunable microenvironmental properties. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine. |
| doi_str_mv | 10.1002/mabi.202100498 |
| format | Article |
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A novel method for inducing multicellular spheroids (MCSs) formation is proposed based on hydrogel with tunable microenvironmental properties. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.202100498</identifier><identifier>PMID: 35014172</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>3D cell culturing ; Cell culture ; Cell Culture Techniques ; Cell Line, Tumor ; Chemotherapy ; Colon ; Deprivation ; Graphene ; Humans ; hydrogel ; Hydrogels ; Hydrogels - chemistry ; Hydrogels - pharmacology ; In vitro methods and tests ; microenvironment properties ; Neoplasms ; Photothermal Therapy ; Precision medicine ; Spheroids ; Spheroids, Cellular ; Substrates ; Synergism ; synergistic treatment ; Tissue culture ; Tumor cells ; Tumors</subject><ispartof>Macromolecular bioscience, 2022-04, Vol.22 (4), p.e2100498-n/a</ispartof><rights>2022 Wiley‐VCH GmbH</rights><rights>2022 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3738-b6c371a1fc1db7cc9e1051dad3da92c76ae76f433000021a622734cf631a22c53</citedby><cites>FETCH-LOGICAL-c3738-b6c371a1fc1db7cc9e1051dad3da92c76ae76f433000021a622734cf631a22c53</cites><orcidid>0000-0001-7501-0420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.202100498$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.202100498$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35014172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Guo, Zhao‐bin</creatorcontrib><creatorcontrib>Nie, Yu‐min</creatorcontrib><creatorcontrib>Feng, Guan‐ping</creatorcontrib><creatorcontrib>Deng, Man‐jiao</creatorcontrib><creatorcontrib>Hu, Yi‐min</creatorcontrib><creatorcontrib>Zhang, Hui‐jie</creatorcontrib><creatorcontrib>Zhao, Yin‐yi</creatorcontrib><creatorcontrib>Feng, Yi‐wei</creatorcontrib><creatorcontrib>Yu, Ting‐ting</creatorcontrib><creatorcontrib>Hu, Ke</creatorcontrib><title>Self‐Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Toward Revealing the Synergy of Chemo‐ and Noninvasive Photothermal Therapy against Colon Microtumor</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>Three‐dimensional (3D) tumor cell culture offers a more tissue‐recapitulating model in cancer treatment evaluation. However, conventional models based on cell‐substrate adhesion deprivation are still of insufficient real tumor mimic. In this work, a novel method is proposed for inducing multicellular spheroids (MCSs) formation based on hydrogel with tunable microenvironmental properties. Colon tumor cells DLD1 cultured on hydrogel substrate with proper physical stimulation form MCSs via self‐organization. Chemotherapy based on clinical drug and far‐infrared photothermal therapy is evaluated with DLD1 MCSs obtained by this method. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and it is believed this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine.
A novel method for inducing multicellular spheroids (MCSs) formation is proposed based on hydrogel with tunable microenvironmental properties. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine.</description><subject>3D cell culturing</subject><subject>Cell culture</subject><subject>Cell Culture Techniques</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Colon</subject><subject>Deprivation</subject><subject>Graphene</subject><subject>Humans</subject><subject>hydrogel</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>In vitro methods and tests</subject><subject>microenvironment properties</subject><subject>Neoplasms</subject><subject>Photothermal Therapy</subject><subject>Precision medicine</subject><subject>Spheroids</subject><subject>Spheroids, Cellular</subject><subject>Substrates</subject><subject>Synergism</subject><subject>synergistic treatment</subject><subject>Tissue culture</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEoqVw5YgsceGyi-38ccKtrCit1KUVu5yjiT3JunLsxU62CicegXfjDXgSvNqySFzwZcbSb7757C9JXjI6Z5Tytz00es4pj5esKh8lp6xgxSxnVf742JfiJHkWwh2lTJQVf5qcpDllGRP8NPm5QtP--v7jxndg9TcYtLPkwvn-0LmWLEczaInGjAY8WW036J1WgSxRaRhQkWaKvdzEcQnGTGQ9WmgMkstJedehIbcGhjZKviNrdw9ekc-4QzDadmTYIFlNFn037XctNti76IaAVeSTs9ruIOgdktuNG1yEoy9D1rHCdiLQgbZhIAtnotWllt4NY-_88-RJCybgi4d6lny5-LBeXM6ubz5eLc6vZzIVaTlrilgZsFYy1QgpK2Q0ZwpUqqDiUhSAomizNKXxcAYF5yLNZFukDDiXeXqWvDnobr37OmIY6l6H_U-BRTeGmhesrGieZSKir_9B79zobXQXqayqBBPZXnB-oOJLQvDY1luve_BTzWi9j7vex10f444Drx5kx6ZHdcT_5BuB6gDca4PTf-Tq5fn7q7_ivwFjYb02</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Zhang, Yi</creator><creator>Guo, Zhao‐bin</creator><creator>Nie, Yu‐min</creator><creator>Feng, Guan‐ping</creator><creator>Deng, Man‐jiao</creator><creator>Hu, Yi‐min</creator><creator>Zhang, Hui‐jie</creator><creator>Zhao, Yin‐yi</creator><creator>Feng, Yi‐wei</creator><creator>Yu, Ting‐ting</creator><creator>Hu, Ke</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7501-0420</orcidid></search><sort><creationdate>202204</creationdate><title>Self‐Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Toward Revealing the Synergy of Chemo‐ and Noninvasive Photothermal Therapy against Colon Microtumor</title><author>Zhang, Yi ; Guo, Zhao‐bin ; Nie, Yu‐min ; Feng, Guan‐ping ; Deng, Man‐jiao ; Hu, Yi‐min ; Zhang, Hui‐jie ; Zhao, Yin‐yi ; Feng, Yi‐wei ; Yu, Ting‐ting ; Hu, Ke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3738-b6c371a1fc1db7cc9e1051dad3da92c76ae76f433000021a622734cf631a22c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>3D cell culturing</topic><topic>Cell culture</topic><topic>Cell Culture Techniques</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Colon</topic><topic>Deprivation</topic><topic>Graphene</topic><topic>Humans</topic><topic>hydrogel</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>In vitro methods and tests</topic><topic>microenvironment properties</topic><topic>Neoplasms</topic><topic>Photothermal Therapy</topic><topic>Precision medicine</topic><topic>Spheroids</topic><topic>Spheroids, Cellular</topic><topic>Substrates</topic><topic>Synergism</topic><topic>synergistic treatment</topic><topic>Tissue culture</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Guo, Zhao‐bin</creatorcontrib><creatorcontrib>Nie, Yu‐min</creatorcontrib><creatorcontrib>Feng, Guan‐ping</creatorcontrib><creatorcontrib>Deng, Man‐jiao</creatorcontrib><creatorcontrib>Hu, Yi‐min</creatorcontrib><creatorcontrib>Zhang, Hui‐jie</creatorcontrib><creatorcontrib>Zhao, Yin‐yi</creatorcontrib><creatorcontrib>Feng, Yi‐wei</creatorcontrib><creatorcontrib>Yu, Ting‐ting</creatorcontrib><creatorcontrib>Hu, Ke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yi</au><au>Guo, Zhao‐bin</au><au>Nie, Yu‐min</au><au>Feng, Guan‐ping</au><au>Deng, Man‐jiao</au><au>Hu, Yi‐min</au><au>Zhang, Hui‐jie</au><au>Zhao, Yin‐yi</au><au>Feng, Yi‐wei</au><au>Yu, Ting‐ting</au><au>Hu, Ke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self‐Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Toward Revealing the Synergy of Chemo‐ and Noninvasive Photothermal Therapy against Colon Microtumor</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2022-04</date><risdate>2022</risdate><volume>22</volume><issue>4</issue><spage>e2100498</spage><epage>n/a</epage><pages>e2100498-n/a</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>Three‐dimensional (3D) tumor cell culture offers a more tissue‐recapitulating model in cancer treatment evaluation. However, conventional models based on cell‐substrate adhesion deprivation are still of insufficient real tumor mimic. In this work, a novel method is proposed for inducing multicellular spheroids (MCSs) formation based on hydrogel with tunable microenvironmental properties. Colon tumor cells DLD1 cultured on hydrogel substrate with proper physical stimulation form MCSs via self‐organization. Chemotherapy based on clinical drug and far‐infrared photothermal therapy is evaluated with DLD1 MCSs obtained by this method. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and it is believed this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine.
A novel method for inducing multicellular spheroids (MCSs) formation is proposed based on hydrogel with tunable microenvironmental properties. The synergism of chemotherapy and noninvasive photothermal therapy based on graphene device is further verified in MCSs model and this method holds potential in in vitro anti‐tumor strategies evaluation for precision medicine.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35014172</pmid><doi>10.1002/mabi.202100498</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7501-0420</orcidid></addata></record> |
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| identifier | ISSN: 1616-5187 |
| ispartof | Macromolecular bioscience, 2022-04, Vol.22 (4), p.e2100498-n/a |
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| subjects | 3D cell culturing Cell culture Cell Culture Techniques Cell Line, Tumor Chemotherapy Colon Deprivation Graphene Humans hydrogel Hydrogels Hydrogels - chemistry Hydrogels - pharmacology In vitro methods and tests microenvironment properties Neoplasms Photothermal Therapy Precision medicine Spheroids Spheroids, Cellular Substrates Synergism synergistic treatment Tissue culture Tumor cells Tumors |
| title | Self‐Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Toward Revealing the Synergy of Chemo‐ and Noninvasive Photothermal Therapy against Colon Microtumor |
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