The pro‐proliferative effect of insulin in human breast epithelial DMBA‐transformed and non‐transformed cell lines is PI3K‐, mTOR‐ and GLUT1‐dependent

Type 2 diabetes mellitus (T2DM) is linked to an increased risk of breast cancer. We aimed to investigate how T2DM‐associated characteristics (high levels of glucose, insulin, leptin, inflammatory mediators and oxidative stress) influence breast cancer carcinogenesis, in DMBA‐treated (MCF‐12ADMBA) an...

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Veröffentlicht in:	Cell biochemistry and function 2022-03, Vol.40 (2), p.127-137
Hauptverfasser:	Silva, Cláudia, Andrade, Nelson, Guimarães, João Tiago, Cardoso, Emília, Meireles, Catarina, Pinto, Vanessa, Paiva, Joana, Martel, Fátima
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acid production Breast cancer Breast Neoplasms - chemically induced Breast Neoplasms - metabolism Carcinogenesis Carcinogens Cell growth Cell Line, Tumor Cell proliferation Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 DMBA Female Glucose Glucose Transporter Type 1 - metabolism GLUT1 Health risks Humans Hyperinsulinemia Inflammation Insulin Insulin - metabolism Insulin - pharmacology Lactic acid Leptin mTOR Oxidative stress Phosphatidylinositol 3-Kinases - metabolism PI3K Proto-Oncogene Proteins c-akt - metabolism Rapamycin Signal Transduction TOR protein TOR Serine-Threonine Kinases - metabolism
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