Sialidase-Conjugated “NanoNiche” for Efficient Immune Checkpoint Blockade Therapy

Reactivation of T-cell immunity by blocking the PD-1/PD-L1 immune checkpoint has been considered a promising strategy for cancer treatment. However, the recognition of PD-L1 by antibodies is usually suppressed due to the N-linked glycosylation of PD-L1. In this study, we present an effective PD-L1-b...

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Veröffentlicht in:	ACS applied bio materials 2021-07, Vol.4 (7), p.5735-5741
Hauptverfasser:	Zhou, Ze-Rui, Wang, Xiao-Yuan, Jiang, Lei, Li, Da-Wei, Qian, Ruo-Can
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen - antagonists & inhibitors Cell Line, Tumor Humans Immune Checkpoint Inhibitors Neoplasms - drug therapy Neuraminidase - therapeutic use T-Lymphocytes - pathology
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