Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections
Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce...
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| Veröffentlicht in: | ACS applied bio materials 2021-05, Vol.4 (5), p.3811-3829 |
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| container_title | ACS applied bio materials |
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| creator | Qian, Yuxin Deng, Shuai Lu, Ziyi She, Yunrui Xie, Jiayang Cong, Zihao Zhang, Wenjing Liu, Runhui |
| description | Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce drug resistance, and remarkable biocompatibility. In this review, covalent-grafting strategies are mainly discussed to tether host defense peptide mimicking polymers on surfaces, aiming to obtain potent antimicrobial activity. In addition to the antimicrobial function, we review the antimicrobial mechanism of these polymer-modified antimicrobial surfaces in precedent literatures. We also review the in vivo subcutaneous implant infection models that are critical assessments for potential biomedical applications. In the end, we provide our perspective on the future development of this field, especially for biomedical applications. |
| doi_str_mv | 10.1021/acsabm.0c01066 |
| format | Article |
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Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce drug resistance, and remarkable biocompatibility. In this review, covalent-grafting strategies are mainly discussed to tether host defense peptide mimicking polymers on surfaces, aiming to obtain potent antimicrobial activity. In addition to the antimicrobial function, we review the antimicrobial mechanism of these polymer-modified antimicrobial surfaces in precedent literatures. We also review the in vivo subcutaneous implant infection models that are critical assessments for potential biomedical applications. 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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Bacteria - drug effects Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Humans Materials Testing Microbial Sensitivity Tests Particle Size Polymers - chemistry Polymers - pharmacology Prostheses and Implants - microbiology Prosthesis-Related Infections - drug therapy Prosthesis-Related Infections - microbiology Surface Properties |
| title | Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections |
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