Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A

Isovitexin (IVT) has been shown to have a potential therapeutic effect on acute liver injury (ALI), but its underlying mechanisms especially the targets remain unclear, which was investigated in the present study. Briefly, the targets of IVT were predicted by bioinformatics and then were verified by...

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Veröffentlicht in:	European journal of pharmacology 2022-02, Vol.917, p.174749, Article 174749
Hauptverfasser:	Huang, Yushen, Chen, Siyun, Pang, Lijun, Feng, Zhongwen, Su, Hongmei, Zhu, Wuchang, Wei, Jinbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute liver injury Animals Apigenin BiP Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Disease Models, Animal Endoplasmic Reticulum Chaperone BiP Galactosamine - toxicity Heat-Shock Proteins - metabolism Humans Isovitexin Lipopolysaccharides Liver - drug effects Liver - metabolism Liver - pathology M6A Male Mice Molecular Docking Simulation Phosphatidylinositol 3-Kinases - metabolism PI3K Protective Agents - pharmacology Protective Agents - therapeutic use Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN Phosphohydrolase - metabolism Signal Transduction - drug effects
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