One-Pot Synthesis of Substituted 2‑Amino Isonicotinic Acids: Reminiscent of the Guareschi–Thorpe Condensation

One-Pot Synthesis of Substituted 2‑Amino Isonicotinic Acids: Reminiscent of the Guareschi–Thorpe Condensation

This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and...

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Veröffentlicht in:Journal of organic chemistry 2022-01, Vol.87 (2), p.1541-1544
Hauptverfasser: Jin, Xiangle, Xing, Lidong, Deng, Daniel Da, Yan, Jun, Fu, Yan, Dong, Weitong
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids
Carboxylic Acids
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Zusammenfassung:This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent of the Guareschi–Thorpe Condensation.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c02483