Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways

Galangin, a bioactive flavonoid with remarkable antioxidant and anti-apoptotic actions, has demonstrated promising amelioration of experimental hepatotoxicity, cardiomyopathy, and colitis. Yet, its impact on cadmium-induced renal injury has not been explored. Herein, we aimed at exploring the potent...

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Veröffentlicht in:	Life sciences (1973) 2022-02, Vol.291, p.120300-120300, Article 120300
Hauptverfasser:	Arab, Hany H., Ashour, Ahmed M., Eid, Ahmed H., Arafa, El-Shaimaa A., Al Khabbaz, Hana J., Abd El-Aal, Sarah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - metabolism AMP-Activated Protein Kinases - metabolism Animals Antioxidants Apoptosis Apoptosis - drug effects Attenuation Autophagy BAX protein Bcl-2 protein Cadmium Cadmium - adverse effects Cadmium - pharmacology Cadmium chloride Cardiomyopathy Caspase-3 Cell death Colitis Creatinine Cytochrome Cytochrome c Cytochromes Damage Enzyme-linked immunosorbent assay Flavonoids Flavonoids - metabolism Flavonoids - pharmacology Galangin Hepatotoxicity Histology Immunohistochemistry Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Diseases - metabolism Kidneys Lipids Male NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Peroxides Protein expression Proteins Rats Rats, Wistar Signal Transduction - drug effects SIRT1 protein Sirtuin 1 - metabolism TOR protein TOR Serine-Threonine Kinases - metabolism
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