Small molecule protein binding to correct cellular folding or stabilize the native state against misfolding and aggregation

Protein misfolding diseases are caused by the difficulty of a protein to attain or stably maintain its native three-dimensional structure. In 2011, the first small molecule that specifically binds to the folded state of a protein was approved by a regulatory agency to treat a protein misfolding dise...

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Veröffentlicht in:	Current opinion in structural biology 2022-02, Vol.72, p.267-278
Hauptverfasser:	Chiti, Fabrizio, Kelly, Jeffery W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Neuropathies, Familial Humans Protein Binding Protein Folding Proteins - chemistry
Online-Zugang:	Volltext
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