Vitamin D levels in Greek patients with systemic lupus erythematosus
Objectives Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity. Methods In a cohort of 45 patients with SLE, 41 females and...
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| Veröffentlicht in: | Lupus 2022-01, Vol.31 (1), p.125-132 |
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| creator | Athanassiou, Lambros Kostoglou-Athanassiou, Ifigenia Tsakiridis, Pavlos Devetzi, Eirini Mavroudi, Maria Fytas, Pantelis Koutsilieris, Michael Athanassiou, Panagiotis |
| description | Objectives
Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity.
Methods
In a cohort of 45 patients with SLE, 41 females and 4 males, aged 47.07 ± 2.17 years (mean ± SEM), and range = 21–79 years, 25(OH)D3 levels were determined by electrochemiluminescence. C3 and C4 levels were also analyzed. SLE disease activity was estimated by SLEDAI-2K. Observations were also performed in a control group matched for age and sex.
Results
In this cohort of SLE patients, 25(OH)D3 levels were 40.36 ± 2.41 nmol/L (mean ± SEM) as opposed to 60.98 ± 4.28 nmol/L in the control group (p < 0.001, Student’s t test). Vitamin D levels were related to C3 (p < 0.001, linear regression analysis), correlation coefficient 0.106, r2 = 0.011, and C4 (p < 0.001); correlation coefficient 0.316 and r2 = 0.100; and inversely related to disease activity (p < 0.001), correlation coefficient −0.572 and r2 = 0.327. 25(OH)D3 levels were 17.73 ± 1.20 nmol/L and 12.24 ± 0.93 nmol/L, in the groups without and with renal involvement, respectively (p = 0.001, Student’s t test).
Conclusions
Vitamin D levels are low in SLE patients and are inversely related to disease activity. Routine screening for vitamin D levels should be performed in SLE patients. |
| doi_str_mv | 10.1177/09612033211066462 |
| format | Article |
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Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity.
Methods
In a cohort of 45 patients with SLE, 41 females and 4 males, aged 47.07 ± 2.17 years (mean ± SEM), and range = 21–79 years, 25(OH)D3 levels were determined by electrochemiluminescence. C3 and C4 levels were also analyzed. SLE disease activity was estimated by SLEDAI-2K. Observations were also performed in a control group matched for age and sex.
Results
In this cohort of SLE patients, 25(OH)D3 levels were 40.36 ± 2.41 nmol/L (mean ± SEM) as opposed to 60.98 ± 4.28 nmol/L in the control group (p < 0.001, Student’s t test). Vitamin D levels were related to C3 (p < 0.001, linear regression analysis), correlation coefficient 0.106, r2 = 0.011, and C4 (p < 0.001); correlation coefficient 0.316 and r2 = 0.100; and inversely related to disease activity (p < 0.001), correlation coefficient −0.572 and r2 = 0.327. 25(OH)D3 levels were 17.73 ± 1.20 nmol/L and 12.24 ± 0.93 nmol/L, in the groups without and with renal involvement, respectively (p = 0.001, Student’s t test).
Conclusions
Vitamin D levels are low in SLE patients and are inversely related to disease activity. Routine screening for vitamin D levels should be performed in SLE patients.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/09612033211066462</identifier><identifier>PMID: 35006029</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Autoimmune Diseases ; Disease ; Female ; Greece ; Humans ; Lupus ; Lupus Erythematosus, Systemic ; Male ; Rheumatoid arthritis ; Systemic lupus erythematosus ; Vitamin D ; Vitamin D - analysis ; Vitamin D - chemistry ; Vitamin D Deficiency - epidemiology ; Vitamin deficiency</subject><ispartof>Lupus, 2022-01, Vol.31 (1), p.125-132</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3194-66b395bd95745fe7304a342aa8cbdda3f2ae93baeecce91fa7324818198e24d83</citedby><cites>FETCH-LOGICAL-c3194-66b395bd95745fe7304a342aa8cbdda3f2ae93baeecce91fa7324818198e24d83</cites><orcidid>0000-0002-2029-8372</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/09612033211066462$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/09612033211066462$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35006029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Athanassiou, Lambros</creatorcontrib><creatorcontrib>Kostoglou-Athanassiou, Ifigenia</creatorcontrib><creatorcontrib>Tsakiridis, Pavlos</creatorcontrib><creatorcontrib>Devetzi, Eirini</creatorcontrib><creatorcontrib>Mavroudi, Maria</creatorcontrib><creatorcontrib>Fytas, Pantelis</creatorcontrib><creatorcontrib>Koutsilieris, Michael</creatorcontrib><creatorcontrib>Athanassiou, Panagiotis</creatorcontrib><title>Vitamin D levels in Greek patients with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objectives
Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity.
Methods
In a cohort of 45 patients with SLE, 41 females and 4 males, aged 47.07 ± 2.17 years (mean ± SEM), and range = 21–79 years, 25(OH)D3 levels were determined by electrochemiluminescence. C3 and C4 levels were also analyzed. SLE disease activity was estimated by SLEDAI-2K. Observations were also performed in a control group matched for age and sex.
Results
In this cohort of SLE patients, 25(OH)D3 levels were 40.36 ± 2.41 nmol/L (mean ± SEM) as opposed to 60.98 ± 4.28 nmol/L in the control group (p < 0.001, Student’s t test). Vitamin D levels were related to C3 (p < 0.001, linear regression analysis), correlation coefficient 0.106, r2 = 0.011, and C4 (p < 0.001); correlation coefficient 0.316 and r2 = 0.100; and inversely related to disease activity (p < 0.001), correlation coefficient −0.572 and r2 = 0.327. 25(OH)D3 levels were 17.73 ± 1.20 nmol/L and 12.24 ± 0.93 nmol/L, in the groups without and with renal involvement, respectively (p = 0.001, Student’s t test).
Conclusions
Vitamin D levels are low in SLE patients and are inversely related to disease activity. Routine screening for vitamin D levels should be performed in SLE patients.</description><subject>Autoimmune Diseases</subject><subject>Disease</subject><subject>Female</subject><subject>Greece</subject><subject>Humans</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic</subject><subject>Male</subject><subject>Rheumatoid arthritis</subject><subject>Systemic lupus erythematosus</subject><subject>Vitamin D</subject><subject>Vitamin D - analysis</subject><subject>Vitamin D - chemistry</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin deficiency</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwzAQhC0EouXxA7ggS1y4pPgVOz6iFgpSJS7ANXKSDU3JC9sB9d_jqgUkEKddab-ZWQ1CZ5RMKFXqimhJGeGcUUqkFJLtoTEVSkXhwPbReHOPNsAIHTm3IoRwquUhGvGYEEmYHqPZc-VNU7V4hmt4h9rhsM8twCvuja-g9Q5_VH6J3dp5aKoc10M_OAx27ZfQGN-5wZ2gg9LUDk538xg93d48Tu-ixcP8fnq9iPKQKyIpM67jrNCxEnEJihNhuGDGJHlWFIaXzIDmmQHIc9C0NIozkdCE6gSYKBJ-jC63vr3t3gZwPm0ql0Ndmxa6waVM0iQOSZQH9OIXuuoG24bvAsWYijmXJFB0S-W2c85Cmfa2aoxdp5Skm4rTPxUHzfnOecgaKL4VX50GYLIFnHmBn9j_HT8B5QOCSQ</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Athanassiou, Lambros</creator><creator>Kostoglou-Athanassiou, Ifigenia</creator><creator>Tsakiridis, Pavlos</creator><creator>Devetzi, Eirini</creator><creator>Mavroudi, Maria</creator><creator>Fytas, Pantelis</creator><creator>Koutsilieris, Michael</creator><creator>Athanassiou, Panagiotis</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2029-8372</orcidid></search><sort><creationdate>202201</creationdate><title>Vitamin D levels in Greek patients with systemic lupus erythematosus</title><author>Athanassiou, Lambros ; Kostoglou-Athanassiou, Ifigenia ; Tsakiridis, Pavlos ; Devetzi, Eirini ; Mavroudi, Maria ; Fytas, Pantelis ; Koutsilieris, Michael ; Athanassiou, Panagiotis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3194-66b395bd95745fe7304a342aa8cbdda3f2ae93baeecce91fa7324818198e24d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Autoimmune Diseases</topic><topic>Disease</topic><topic>Female</topic><topic>Greece</topic><topic>Humans</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic</topic><topic>Male</topic><topic>Rheumatoid arthritis</topic><topic>Systemic lupus erythematosus</topic><topic>Vitamin D</topic><topic>Vitamin D - analysis</topic><topic>Vitamin D - chemistry</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Athanassiou, Lambros</creatorcontrib><creatorcontrib>Kostoglou-Athanassiou, Ifigenia</creatorcontrib><creatorcontrib>Tsakiridis, Pavlos</creatorcontrib><creatorcontrib>Devetzi, Eirini</creatorcontrib><creatorcontrib>Mavroudi, Maria</creatorcontrib><creatorcontrib>Fytas, Pantelis</creatorcontrib><creatorcontrib>Koutsilieris, Michael</creatorcontrib><creatorcontrib>Athanassiou, Panagiotis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Athanassiou, Lambros</au><au>Kostoglou-Athanassiou, Ifigenia</au><au>Tsakiridis, Pavlos</au><au>Devetzi, Eirini</au><au>Mavroudi, Maria</au><au>Fytas, Pantelis</au><au>Koutsilieris, Michael</au><au>Athanassiou, Panagiotis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D levels in Greek patients with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2022-01</date><risdate>2022</risdate><volume>31</volume><issue>1</issue><spage>125</spage><epage>132</epage><pages>125-132</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Objectives
Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity.
Methods
In a cohort of 45 patients with SLE, 41 females and 4 males, aged 47.07 ± 2.17 years (mean ± SEM), and range = 21–79 years, 25(OH)D3 levels were determined by electrochemiluminescence. C3 and C4 levels were also analyzed. SLE disease activity was estimated by SLEDAI-2K. Observations were also performed in a control group matched for age and sex.
Results
In this cohort of SLE patients, 25(OH)D3 levels were 40.36 ± 2.41 nmol/L (mean ± SEM) as opposed to 60.98 ± 4.28 nmol/L in the control group (p < 0.001, Student’s t test). Vitamin D levels were related to C3 (p < 0.001, linear regression analysis), correlation coefficient 0.106, r2 = 0.011, and C4 (p < 0.001); correlation coefficient 0.316 and r2 = 0.100; and inversely related to disease activity (p < 0.001), correlation coefficient −0.572 and r2 = 0.327. 25(OH)D3 levels were 17.73 ± 1.20 nmol/L and 12.24 ± 0.93 nmol/L, in the groups without and with renal involvement, respectively (p = 0.001, Student’s t test).
Conclusions
Vitamin D levels are low in SLE patients and are inversely related to disease activity. Routine screening for vitamin D levels should be performed in SLE patients.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>35006029</pmid><doi>10.1177/09612033211066462</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2029-8372</orcidid></addata></record> |
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| subjects | Autoimmune Diseases Disease Female Greece Humans Lupus Lupus Erythematosus, Systemic Male Rheumatoid arthritis Systemic lupus erythematosus Vitamin D Vitamin D - analysis Vitamin D - chemistry Vitamin D Deficiency - epidemiology Vitamin deficiency |
| title | Vitamin D levels in Greek patients with systemic lupus erythematosus |
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