Phylogeny of the HO family in cyprinus carpio and the response of the HO-1 gene to adding Bacillus coagulans in feed under Cd2+ stress
The heavy metal cadmium (Cd 2+ ) is an environmental pollutant that poses serious health hazards. Due to the increasing contamination of aquatic systems with Cd 2+ , the increased accumulation of Cd 2+ in fish has become a food safety and public health concern. Heme oxygenase ( HO ) is an important...
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| creator | Jiang, Zhou Zhang, Meng Liu, Kaiyue Xue, Yaguo Li, Xuejun Dong, Chuanju |
| description | The heavy metal cadmium (Cd
2+
) is an environmental pollutant that poses serious health hazards. Due to the increasing contamination of aquatic systems with Cd
2+
, the increased accumulation of Cd
2+
in fish has become a food safety and public health concern. Heme oxygenase (
HO
) is an important antioxidant enzyme that plays a key role in defending the body against oxidative damage, but little research has been done in common carp. In this study, 6
HO
genes were identified in the common carp genome database. Comparative genomics analysis showed considerable expansion of the
HO
genes and verified the four-round whole genome duplication (WGD) event in common carp. Phylogenetic analysis revealed that all
HO
genes of common carp were clustered into orthologous groups, indicating high conservation during evolution. In addition, the tissue distribution results showed that most
HO
genes had extensive tissue distribution and showed tissue-specific expression patterns. Exposure to 0.5 mg/L Cd
2+
significantly reduced the expression of
TGF-β
and
IL-10
in common carp, which may indicate that Cd
2+
exposure can destroy the physical barrier function of the intestine, inhibit intestinal immune defense and induce intestinal inflammation. To find a suitable concentration of
Bacillus coagulans
that could activate
HO-1
genes and the immunity of the organism, we investigated the changes in
HO-1
gene expression levels in the intestinal tract of common carp under Cd
2+
stress at 30 days and 60 days by adding different concentrations of
B. coagulans
to the feed. Compared with the Cd
2+
stress group without supplementation, the expression levels of the
HO-1
gene in the gut of three different concentrations of
B. coagulans
were almost increased. And
B. coagulans
with L2 concentrations had better activation effect on the
HO-1
gene. Similarly, compared to the Cd
2+
stressed group, adding
B. coagulans
to the diet can almost cause the early upregulation of
IL-10
and
TGF-β
genes. Therefore, the addition of appropriate concentrations of
B. coagulans
may be a good way to activate
HO-1
,
IL-10
, and
TGF-β
genes, reduce oxidative damage, and encourage the immune. |
| doi_str_mv | 10.1007/s10695-021-01041-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2618503632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2618503632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-7e8416d8ae9bc4fc1807f1bbfecad1b522eb0571834f193787a737f05085c7233</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi1EJZaFF-BkiQsScpmx49g5wgraSpXKAc6W49jbVFl7sZNDXoDnrrdbqRIHTnP5_m9G8xPyAeESAdSXgtB2kgFHBggNMvmKbFAqwSS2-jXZQMeBoWr4G_K2lAcA6FSLG_L35_06pb2PK02BzveeXt_RYA_jtNIxUrce8xiXQp3NxzFRG4cnKPtyTLH4lxBDWi2ezhUahjHu6Tfrxmk6ZZPdL5ON5WQM3g90iYPPdDfwz7TM1VXekYtgp-LfP88t-f3j-6_dNbu9u7rZfb1ljms-M-V1g-2gre961wSHGlTAvg_e2QF7ybnvQSrUognYCaWVVUIFkKClU1yILfl09h5z-rP4MpvDWJyf6nU-LcXwFrUE0Qpe0Y__oA9pybFeVymuG2hE3bMl_Ey5nErJPpj6sIPNq0Ewp2rMuRpTqzFP1RhZQ-IcKqfv7n1-Uf8n9QiN5pAk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628404318</pqid></control><display><type>article</type><title>Phylogeny of the HO family in cyprinus carpio and the response of the HO-1 gene to adding Bacillus coagulans in feed under Cd2+ stress</title><source>Springer Nature - Complete Springer Journals</source><creator>Jiang, Zhou ; Zhang, Meng ; Liu, Kaiyue ; Xue, Yaguo ; Li, Xuejun ; Dong, Chuanju</creator><creatorcontrib>Jiang, Zhou ; Zhang, Meng ; Liu, Kaiyue ; Xue, Yaguo ; Li, Xuejun ; Dong, Chuanju</creatorcontrib><description>The heavy metal cadmium (Cd
2+
) is an environmental pollutant that poses serious health hazards. Due to the increasing contamination of aquatic systems with Cd
2+
, the increased accumulation of Cd
2+
in fish has become a food safety and public health concern. Heme oxygenase (
HO
) is an important antioxidant enzyme that plays a key role in defending the body against oxidative damage, but little research has been done in common carp. In this study, 6
HO
genes were identified in the common carp genome database. Comparative genomics analysis showed considerable expansion of the
HO
genes and verified the four-round whole genome duplication (WGD) event in common carp. Phylogenetic analysis revealed that all
HO
genes of common carp were clustered into orthologous groups, indicating high conservation during evolution. In addition, the tissue distribution results showed that most
HO
genes had extensive tissue distribution and showed tissue-specific expression patterns. Exposure to 0.5 mg/L Cd
2+
significantly reduced the expression of
TGF-β
and
IL-10
in common carp, which may indicate that Cd
2+
exposure can destroy the physical barrier function of the intestine, inhibit intestinal immune defense and induce intestinal inflammation. To find a suitable concentration of
Bacillus coagulans
that could activate
HO-1
genes and the immunity of the organism, we investigated the changes in
HO-1
gene expression levels in the intestinal tract of common carp under Cd
2+
stress at 30 days and 60 days by adding different concentrations of
B. coagulans
to the feed. Compared with the Cd
2+
stress group without supplementation, the expression levels of the
HO-1
gene in the gut of three different concentrations of
B. coagulans
were almost increased. And
B. coagulans
with L2 concentrations had better activation effect on the
HO-1
gene. Similarly, compared to the Cd
2+
stressed group, adding
B. coagulans
to the diet can almost cause the early upregulation of
IL-10
and
TGF-β
genes. Therefore, the addition of appropriate concentrations of
B. coagulans
may be a good way to activate
HO-1
,
IL-10
, and
TGF-β
genes, reduce oxidative damage, and encourage the immune.</description><identifier>ISSN: 0920-1742</identifier><identifier>EISSN: 1573-5168</identifier><identifier>DOI: 10.1007/s10695-021-01041-5</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Animal Physiology ; Antioxidants ; Aquatic environment ; Bacillus coagulans ; Barriers ; Biomedical and Life Sciences ; Cadmium ; Carp ; Cyprinus carpio ; Damage ; Distribution ; Evolutionary conservation ; Evolutionary genetics ; Feeds ; Fish ; Food contamination ; Food safety ; Freshwater & Marine Ecology ; Freshwater fishes ; Gene expression ; Genes ; Genomes ; Genomics ; Health hazards ; Heavy metals ; Heme ; Heme oxygenase (decyclizing) ; Histology ; Immune system ; Immunity ; Interleukin 10 ; Intestine ; Intestines ; Life Sciences ; Morphology ; Oxygenase ; Phylogeny ; Pollutants ; Public health ; Tissue ; Transforming growth factor-b ; Zoology</subject><ispartof>Fish physiology and biochemistry, 2022-02, Vol.48 (1), p.117-131</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-7e8416d8ae9bc4fc1807f1bbfecad1b522eb0571834f193787a737f05085c7233</citedby><cites>FETCH-LOGICAL-c282t-7e8416d8ae9bc4fc1807f1bbfecad1b522eb0571834f193787a737f05085c7233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10695-021-01041-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10695-021-01041-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Jiang, Zhou</creatorcontrib><creatorcontrib>Zhang, Meng</creatorcontrib><creatorcontrib>Liu, Kaiyue</creatorcontrib><creatorcontrib>Xue, Yaguo</creatorcontrib><creatorcontrib>Li, Xuejun</creatorcontrib><creatorcontrib>Dong, Chuanju</creatorcontrib><title>Phylogeny of the HO family in cyprinus carpio and the response of the HO-1 gene to adding Bacillus coagulans in feed under Cd2+ stress</title><title>Fish physiology and biochemistry</title><addtitle>Fish Physiol Biochem</addtitle><description>The heavy metal cadmium (Cd
2+
) is an environmental pollutant that poses serious health hazards. Due to the increasing contamination of aquatic systems with Cd
2+
, the increased accumulation of Cd
2+
in fish has become a food safety and public health concern. Heme oxygenase (
HO
) is an important antioxidant enzyme that plays a key role in defending the body against oxidative damage, but little research has been done in common carp. In this study, 6
HO
genes were identified in the common carp genome database. Comparative genomics analysis showed considerable expansion of the
HO
genes and verified the four-round whole genome duplication (WGD) event in common carp. Phylogenetic analysis revealed that all
HO
genes of common carp were clustered into orthologous groups, indicating high conservation during evolution. In addition, the tissue distribution results showed that most
HO
genes had extensive tissue distribution and showed tissue-specific expression patterns. Exposure to 0.5 mg/L Cd
2+
significantly reduced the expression of
TGF-β
and
IL-10
in common carp, which may indicate that Cd
2+
exposure can destroy the physical barrier function of the intestine, inhibit intestinal immune defense and induce intestinal inflammation. To find a suitable concentration of
Bacillus coagulans
that could activate
HO-1
genes and the immunity of the organism, we investigated the changes in
HO-1
gene expression levels in the intestinal tract of common carp under Cd
2+
stress at 30 days and 60 days by adding different concentrations of
B. coagulans
to the feed. Compared with the Cd
2+
stress group without supplementation, the expression levels of the
HO-1
gene in the gut of three different concentrations of
B. coagulans
were almost increased. And
B. coagulans
with L2 concentrations had better activation effect on the
HO-1
gene. Similarly, compared to the Cd
2+
stressed group, adding
B. coagulans
to the diet can almost cause the early upregulation of
IL-10
and
TGF-β
genes. Therefore, the addition of appropriate concentrations of
B. coagulans
may be a good way to activate
HO-1
,
IL-10
, and
TGF-β
genes, reduce oxidative damage, and encourage the immune.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animal Physiology</subject><subject>Antioxidants</subject><subject>Aquatic environment</subject><subject>Bacillus coagulans</subject><subject>Barriers</subject><subject>Biomedical and Life Sciences</subject><subject>Cadmium</subject><subject>Carp</subject><subject>Cyprinus carpio</subject><subject>Damage</subject><subject>Distribution</subject><subject>Evolutionary conservation</subject><subject>Evolutionary genetics</subject><subject>Feeds</subject><subject>Fish</subject><subject>Food contamination</subject><subject>Food safety</subject><subject>Freshwater & Marine Ecology</subject><subject>Freshwater fishes</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health hazards</subject><subject>Heavy metals</subject><subject>Heme</subject><subject>Heme oxygenase (decyclizing)</subject><subject>Histology</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Interleukin 10</subject><subject>Intestine</subject><subject>Intestines</subject><subject>Life Sciences</subject><subject>Morphology</subject><subject>Oxygenase</subject><subject>Phylogeny</subject><subject>Pollutants</subject><subject>Public health</subject><subject>Tissue</subject><subject>Transforming growth factor-b</subject><subject>Zoology</subject><issn>0920-1742</issn><issn>1573-5168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFu1DAQhi1EJZaFF-BkiQsScpmx49g5wgraSpXKAc6W49jbVFl7sZNDXoDnrrdbqRIHTnP5_m9G8xPyAeESAdSXgtB2kgFHBggNMvmKbFAqwSS2-jXZQMeBoWr4G_K2lAcA6FSLG_L35_06pb2PK02BzveeXt_RYA_jtNIxUrce8xiXQp3NxzFRG4cnKPtyTLH4lxBDWi2ezhUahjHu6Tfrxmk6ZZPdL5ON5WQM3g90iYPPdDfwz7TM1VXekYtgp-LfP88t-f3j-6_dNbu9u7rZfb1ljms-M-V1g-2gre961wSHGlTAvg_e2QF7ybnvQSrUognYCaWVVUIFkKClU1yILfl09h5z-rP4MpvDWJyf6nU-LcXwFrUE0Qpe0Y__oA9pybFeVymuG2hE3bMl_Ey5nErJPpj6sIPNq0Ewp2rMuRpTqzFP1RhZQ-IcKqfv7n1-Uf8n9QiN5pAk</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Jiang, Zhou</creator><creator>Zhang, 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B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Phylogeny of the HO family in cyprinus carpio and the response of the HO-1 gene to adding Bacillus coagulans in feed under Cd2+ stress</title><author>Jiang, Zhou ; Zhang, Meng ; Liu, Kaiyue ; Xue, Yaguo ; Li, Xuejun ; Dong, Chuanju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-7e8416d8ae9bc4fc1807f1bbfecad1b522eb0571834f193787a737f05085c7233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animal Physiology</topic><topic>Antioxidants</topic><topic>Aquatic environment</topic><topic>Bacillus coagulans</topic><topic>Barriers</topic><topic>Biomedical and Life Sciences</topic><topic>Cadmium</topic><topic>Carp</topic><topic>Cyprinus carpio</topic><topic>Damage</topic><topic>Distribution</topic><topic>Evolutionary conservation</topic><topic>Evolutionary genetics</topic><topic>Feeds</topic><topic>Fish</topic><topic>Food contamination</topic><topic>Food safety</topic><topic>Freshwater & Marine Ecology</topic><topic>Freshwater fishes</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health hazards</topic><topic>Heavy metals</topic><topic>Heme</topic><topic>Heme oxygenase (decyclizing)</topic><topic>Histology</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Interleukin 10</topic><topic>Intestine</topic><topic>Intestines</topic><topic>Life Sciences</topic><topic>Morphology</topic><topic>Oxygenase</topic><topic>Phylogeny</topic><topic>Pollutants</topic><topic>Public health</topic><topic>Tissue</topic><topic>Transforming growth factor-b</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Zhou</creatorcontrib><creatorcontrib>Zhang, Meng</creatorcontrib><creatorcontrib>Liu, Kaiyue</creatorcontrib><creatorcontrib>Xue, Yaguo</creatorcontrib><creatorcontrib>Li, Xuejun</creatorcontrib><creatorcontrib>Dong, Chuanju</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital 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Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Fish physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Zhou</au><au>Zhang, Meng</au><au>Liu, Kaiyue</au><au>Xue, Yaguo</au><au>Li, Xuejun</au><au>Dong, Chuanju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phylogeny of the HO family in cyprinus carpio and the response of the HO-1 gene to adding Bacillus coagulans in feed under Cd2+ stress</atitle><jtitle>Fish physiology and biochemistry</jtitle><stitle>Fish Physiol Biochem</stitle><date>2022-02-01</date><risdate>2022</risdate><volume>48</volume><issue>1</issue><spage>117</spage><epage>131</epage><pages>117-131</pages><issn>0920-1742</issn><eissn>1573-5168</eissn><abstract>The heavy metal cadmium (Cd
2+
) is an environmental pollutant that poses serious health hazards. Due to the increasing contamination of aquatic systems with Cd
2+
, the increased accumulation of Cd
2+
in fish has become a food safety and public health concern. Heme oxygenase (
HO
) is an important antioxidant enzyme that plays a key role in defending the body against oxidative damage, but little research has been done in common carp. In this study, 6
HO
genes were identified in the common carp genome database. Comparative genomics analysis showed considerable expansion of the
HO
genes and verified the four-round whole genome duplication (WGD) event in common carp. Phylogenetic analysis revealed that all
HO
genes of common carp were clustered into orthologous groups, indicating high conservation during evolution. In addition, the tissue distribution results showed that most
HO
genes had extensive tissue distribution and showed tissue-specific expression patterns. Exposure to 0.5 mg/L Cd
2+
significantly reduced the expression of
TGF-β
and
IL-10
in common carp, which may indicate that Cd
2+
exposure can destroy the physical barrier function of the intestine, inhibit intestinal immune defense and induce intestinal inflammation. To find a suitable concentration of
Bacillus coagulans
that could activate
HO-1
genes and the immunity of the organism, we investigated the changes in
HO-1
gene expression levels in the intestinal tract of common carp under Cd
2+
stress at 30 days and 60 days by adding different concentrations of
B. coagulans
to the feed. Compared with the Cd
2+
stress group without supplementation, the expression levels of the
HO-1
gene in the gut of three different concentrations of
B. coagulans
were almost increased. And
B. coagulans
with L2 concentrations had better activation effect on the
HO-1
gene. Similarly, compared to the Cd
2+
stressed group, adding
B. coagulans
to the diet can almost cause the early upregulation of
IL-10
and
TGF-β
genes. Therefore, the addition of appropriate concentrations of
B. coagulans
may be a good way to activate
HO-1
,
IL-10
, and
TGF-β
genes, reduce oxidative damage, and encourage the immune.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10695-021-01041-5</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-1742 |
| ispartof | Fish physiology and biochemistry, 2022-02, Vol.48 (1), p.117-131 |
| issn | 0920-1742 1573-5168 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2618503632 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Animal Anatomy Animal Biochemistry Animal Physiology Antioxidants Aquatic environment Bacillus coagulans Barriers Biomedical and Life Sciences Cadmium Carp Cyprinus carpio Damage Distribution Evolutionary conservation Evolutionary genetics Feeds Fish Food contamination Food safety Freshwater & Marine Ecology Freshwater fishes Gene expression Genes Genomes Genomics Health hazards Heavy metals Heme Heme oxygenase (decyclizing) Histology Immune system Immunity Interleukin 10 Intestine Intestines Life Sciences Morphology Oxygenase Phylogeny Pollutants Public health Tissue Transforming growth factor-b Zoology |
| title | Phylogeny of the HO family in cyprinus carpio and the response of the HO-1 gene to adding Bacillus coagulans in feed under Cd2+ stress |
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