Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy

Ulcerative colitis (UC) is a recurrent chronic inflammatory disease. The symptom of UC is mainly diarrhea including bloody stools. Increasing evidence has suggested that procyanidin A1 (PCA1) exerts an anti-inflammatory effect in several diseases. However, the role of PCA1 in UC is still a mystery....

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Veröffentlicht in:	Journal of physiology and biochemistry 2022-02, Vol.78 (1), p.213-227
Hauptverfasser:	Zhang, Haihua, Lang, Wuying, Liu, Xin, Bai, Jiangsong, Jia, Qinghui, Shi, Qiumei
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animal Physiology Animals Apoptosis Autophagy Biomedical and Life Sciences Biomedicine Catechin Cell growth Cell proliferation Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - metabolism Colon Cytokines Dextran Dextran Sulfate Dextrans Diarrhea Health services Human Physiology In vivo methods and tests Inflammatory bowel disease Inflammatory bowel diseases Length-weight relationships Lipopolysaccharides Mice Original Article Proanthocyanidins Procyanidins Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal transduction Signaling TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Ulcerative colitis Weight loss Weight reduction
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