Diagnosis and treatment monitoring in breast cancer: how liquid biopsy can support patient management
Imaging and tissue biopsies represent the current gold standard for breast cancer diagnosis and patient management. However, these practices are time-consuming, expensive and require invasive procedures. Moreover, tissue biopsies do not capture spatial and temporal tumor heterogeneity. Conversely, l...
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| Veröffentlicht in: | Pharmacogenomics 2022-01, Vol.23 (2), p.119-134 |
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| container_title | Pharmacogenomics |
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| creator | Cucchiara, Federico Scarpitta, Rosa Crucitta, Stefania Scatena, Cristian Arici, Roberta Naccarato, Antonio Giuseppe Fogli, Stefano Danesi, Romano Del Re, Marzia |
| description | Imaging and tissue biopsies represent the current gold standard for breast cancer diagnosis and patient management. However, these practices are time-consuming, expensive and require invasive procedures. Moreover, tissue biopsies do not capture spatial and temporal tumor heterogeneity. Conversely, liquid biopsy, which includes circulating tumor cells, circulating free nucleic acids and extracellular vesicles, is minimally invasive, easy to perform and can be repeated during a patient's follow-up. Increasing evidence also suggests that liquid biopsy can be used to efficiently screen and diagnose tumors at an early stage, and to monitor changes in the tumor molecular profile. In the present review, clinical applications and prospects are discussed. |
| doi_str_mv | 10.2217/pgs-2021-0099 |
| format | Article |
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However, these practices are time-consuming, expensive and require invasive procedures. Moreover, tissue biopsies do not capture spatial and temporal tumor heterogeneity. Conversely, liquid biopsy, which includes circulating tumor cells, circulating free nucleic acids and extracellular vesicles, is minimally invasive, easy to perform and can be repeated during a patient's follow-up. Increasing evidence also suggests that liquid biopsy can be used to efficiently screen and diagnose tumors at an early stage, and to monitor changes in the tumor molecular profile. 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| subjects | biomarkers Biomarkers, Tumor breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Breast Neoplasms - therapy circulating tumor cells circulating tumor DNA diagnosis DNA, Neoplasm - metabolism exosomes Female Humans liquid biopsy Liquid Biopsy - methods Neoplastic Cells, Circulating - pathology prediction Prognosis treatment monitoring |
| title | Diagnosis and treatment monitoring in breast cancer: how liquid biopsy can support patient management |
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