Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russ...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2022, Vol.172 (3), p.359-363 |
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| creator | Kanygin, V. V. Kasatova, A. I. Zavjalov, E. L. Razumov, I. A. Kolesnikov, S. I. Kichigin, A. I. Solov’eva, O. I. Tsygankova, A. R. Taskaev, S. Yu Kasatov, D. A. Sycheva, T. V. Byvaltsev, V. A. |
| description | Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation). |
| doi_str_mv | 10.1007/s10517-022-05392-8 |
| format | Article |
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V.</creatorcontrib><creatorcontrib>Kasatova, A. I.</creatorcontrib><creatorcontrib>Zavjalov, E. L.</creatorcontrib><creatorcontrib>Razumov, I. A.</creatorcontrib><creatorcontrib>Kolesnikov, S. I.</creatorcontrib><creatorcontrib>Kichigin, A. I.</creatorcontrib><creatorcontrib>Solov’eva, O. I.</creatorcontrib><creatorcontrib>Tsygankova, A. R.</creatorcontrib><creatorcontrib>Taskaev, S. Yu</creatorcontrib><creatorcontrib>Kasatov, D. A.</creatorcontrib><creatorcontrib>Sycheva, T. V.</creatorcontrib><creatorcontrib>Byvaltsev, V. A.</creatorcontrib><title>Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. 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V. ; Kasatova, A. I. ; Zavjalov, E. L. ; Razumov, I. A. ; Kolesnikov, S. I. ; Kichigin, A. I. ; Solov’eva, O. I. ; Tsygankova, A. R. ; Taskaev, S. Yu ; Kasatov, D. A. ; Sycheva, T. V. ; Byvaltsev, V. 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| subjects | Adenocarcinoma Adenocarcinoma - radiotherapy Animals Biomedical and Life Sciences Biomedicine Boron Boron Neutron Capture Therapy - methods Boron-neutron capture therapy Brain Neoplasms Cancer Cell Biology Colon Colon cancer Colorectal cancer Colorectal Neoplasms - radiotherapy Comparative analysis Heterografts Humans Immunodeficiency Internal Medicine Laboratory Medicine Mice Mice, SCID Neutrons Nuclear physics Oncology Pathology Radiation Sulfhydryl Compounds Tumors Xenografts |
| title | Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice |
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