Kinetics of atrial and brain natriuretic peptides during hemodialysis are regulated in association with different cardiac functional changes
The blood levels of atrial and brain natriuretic peptides (ANP and BNP) are both increased markedly in hemodialysis patients, but the kinetics of the two are not always parallel. The present study investigated the association of changes in ANP and BNP levels before and after dialysis with changes in...
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| Veröffentlicht in: | Heart and vessels 2022-07, Vol.37 (7), p.1146-1152 |
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| description | The blood levels of atrial and brain natriuretic peptides (ANP and BNP) are both increased markedly in hemodialysis patients, but the kinetics of the two are not always parallel. The present study investigated the association of changes in ANP and BNP levels before and after dialysis with changes in cardiac function in hemodialysis patients. A total of 57 patients (mean age 64 years, 47 males and 10 females) on maintenance hemodialysis with sinus rhythm were enrolled. Blood samples were taken at the beginning and end of dialysis, and plasma levels of ANP and BNP were measured. Changes in cardiac function during dialysis were examined by echocardiography performed just before and after dialysis. Both plasma ANP and BNP concentrations decreased significantly after hemodialysis, but the rate of decrease in BNP [mean ± SD, 555 ± 503 to 519 ± 477 pg/mL (− 6.4%),
P
= 0.011] was much smaller than that in ANP [233 ± 123 to 132 ± 83 pg/mL (− 43.4%),
P
|
| doi_str_mv | 10.1007/s00380-021-02011-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2618500933</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2618500933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-dde827c79204a2a478e7ba167ed0747101df60ca0a3700e14342315e918e55b83</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi0EokvhBTggS1y4BGbsOE6OqOJP1Upc6Nny2pNdV1kn2IlWfQceuk63gMShB8vW-Pd9M5qPsbcIHxFAf8oAsoUKBJYDiNXxGdtgg6oSSsvnbAMdQtVKoc_Yq5xvAVB12L1kZ1KVN9Zqw35fhUhzcJmPPbdzCnbgNnq-TTZEHtfKklaATzTNwVPmfkkh7vieDqMv-F0OmdtEPNFuGexMnhelzXl0wc5hjPwY5j33oe8pUZy5s6noHO-X6Nb_0tHtbdxRfs1e9HbI9ObxPmc3X7_8vPheXf_4dnnx-bpysuvmyntqhXa6E1BbYWvdkt5abDR50LVGQN834CxYqQEIa1kLiYo6bEmpbSvP2YeT75TGXwvl2RxCdjQMNtK4ZCMabMuGOikL-v4_9HZcUpl5pTQ0ohGoCiVOlEtjzol6M6VwsOnOIJg1K3PKypSszENW5lhE7x6tl-2B_F_Jn3AKIE9AntaNU_rX-wnbe5VBoTc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2670626215</pqid></control><display><type>article</type><title>Kinetics of atrial and brain natriuretic peptides during hemodialysis are regulated in association with different cardiac functional changes</title><source>SpringerNature Journals</source><creator>Horio, Takeshi ; Ito, Shogo ; Fujimoto, Kohei ; Izumiya, Yasuhiro ; Yoshiyama, Minoru ; Iwashima, Yoshio ; Nakamura, Satoko ; Yoshihara, Fumiki</creator><creatorcontrib>Horio, Takeshi ; Ito, Shogo ; Fujimoto, Kohei ; Izumiya, Yasuhiro ; Yoshiyama, Minoru ; Iwashima, Yoshio ; Nakamura, Satoko ; Yoshihara, Fumiki</creatorcontrib><description>The blood levels of atrial and brain natriuretic peptides (ANP and BNP) are both increased markedly in hemodialysis patients, but the kinetics of the two are not always parallel. The present study investigated the association of changes in ANP and BNP levels before and after dialysis with changes in cardiac function in hemodialysis patients. A total of 57 patients (mean age 64 years, 47 males and 10 females) on maintenance hemodialysis with sinus rhythm were enrolled. Blood samples were taken at the beginning and end of dialysis, and plasma levels of ANP and BNP were measured. Changes in cardiac function during dialysis were examined by echocardiography performed just before and after dialysis. Both plasma ANP and BNP concentrations decreased significantly after hemodialysis, but the rate of decrease in BNP [mean ± SD, 555 ± 503 to 519 ± 477 pg/mL (− 6.4%),
P
= 0.011] was much smaller than that in ANP [233 ± 123 to 132 ± 83 pg/mL (− 43.4%),
P
< 0.001]. As for the relation to the changes in echocardiographic parameters before and after dialysis, the decrease in inferior vena cava diameter had a close correlation with the decrease in ANP (
r
= 0.528,
P
< 0.001), but not BNP. In contrast, the decrease in left ventricular end-diastolic volume index was correlated only with the decrease in BNP (
r
= 0.297,
P
= 0.035). The peak velocity ratio of early diastolic to atrial filling decreased with preload reduction by dialysis, and its decrease was more strongly correlated with the decrease in BNP (
r
= 0.407,
P
= 0.002) than that in ANP (
r
= 0.273,
P
= 0.040). These results demonstrated that in hemodialysis patients, the decrease in plasma ANP by a single dialysis was essentially caused by blood volume reduction, while BNP decrease was mainly induced by the reduction of left ventricular overload. Our findings indicate that the kinetics of both peptides during dialysis are regulated by different cardiac and hemodynamic factors.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-021-02011-w</identifier><identifier>PMID: 35001145</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Biomedical Engineering and Bioengineering ; Blood ; Blood levels ; Blood volume ; Brain ; Brain natriuretic peptide ; Cardiac function ; Cardiac Surgery ; Cardiology ; Correlation ; Dialysis ; Diameters ; Echocardiography ; Heart ; Hemodialysis ; Hemodynamics ; Kinetics ; Medicine ; Medicine & Public Health ; Original Article ; Peptides ; Plasma levels ; Reduction ; Vascular Surgery ; Ventricle</subject><ispartof>Heart and vessels, 2022-07, Vol.37 (7), p.1146-1152</ispartof><rights>Springer Japan KK, part of Springer Nature 2021</rights><rights>2021. Springer Japan KK, part of Springer Nature.</rights><rights>Springer Japan KK, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-dde827c79204a2a478e7ba167ed0747101df60ca0a3700e14342315e918e55b83</citedby><cites>FETCH-LOGICAL-c399t-dde827c79204a2a478e7ba167ed0747101df60ca0a3700e14342315e918e55b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-021-02011-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-021-02011-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35001145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horio, Takeshi</creatorcontrib><creatorcontrib>Ito, Shogo</creatorcontrib><creatorcontrib>Fujimoto, Kohei</creatorcontrib><creatorcontrib>Izumiya, Yasuhiro</creatorcontrib><creatorcontrib>Yoshiyama, Minoru</creatorcontrib><creatorcontrib>Iwashima, Yoshio</creatorcontrib><creatorcontrib>Nakamura, Satoko</creatorcontrib><creatorcontrib>Yoshihara, Fumiki</creatorcontrib><title>Kinetics of atrial and brain natriuretic peptides during hemodialysis are regulated in association with different cardiac functional changes</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>The blood levels of atrial and brain natriuretic peptides (ANP and BNP) are both increased markedly in hemodialysis patients, but the kinetics of the two are not always parallel. The present study investigated the association of changes in ANP and BNP levels before and after dialysis with changes in cardiac function in hemodialysis patients. A total of 57 patients (mean age 64 years, 47 males and 10 females) on maintenance hemodialysis with sinus rhythm were enrolled. Blood samples were taken at the beginning and end of dialysis, and plasma levels of ANP and BNP were measured. Changes in cardiac function during dialysis were examined by echocardiography performed just before and after dialysis. Both plasma ANP and BNP concentrations decreased significantly after hemodialysis, but the rate of decrease in BNP [mean ± SD, 555 ± 503 to 519 ± 477 pg/mL (− 6.4%),
P
= 0.011] was much smaller than that in ANP [233 ± 123 to 132 ± 83 pg/mL (− 43.4%),
P
< 0.001]. As for the relation to the changes in echocardiographic parameters before and after dialysis, the decrease in inferior vena cava diameter had a close correlation with the decrease in ANP (
r
= 0.528,
P
< 0.001), but not BNP. In contrast, the decrease in left ventricular end-diastolic volume index was correlated only with the decrease in BNP (
r
= 0.297,
P
= 0.035). The peak velocity ratio of early diastolic to atrial filling decreased with preload reduction by dialysis, and its decrease was more strongly correlated with the decrease in BNP (
r
= 0.407,
P
= 0.002) than that in ANP (
r
= 0.273,
P
= 0.040). These results demonstrated that in hemodialysis patients, the decrease in plasma ANP by a single dialysis was essentially caused by blood volume reduction, while BNP decrease was mainly induced by the reduction of left ventricular overload. Our findings indicate that the kinetics of both peptides during dialysis are regulated by different cardiac and hemodynamic factors.</description><subject>Biomedical Engineering and Bioengineering</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Blood volume</subject><subject>Brain</subject><subject>Brain natriuretic peptide</subject><subject>Cardiac function</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Correlation</subject><subject>Dialysis</subject><subject>Diameters</subject><subject>Echocardiography</subject><subject>Heart</subject><subject>Hemodialysis</subject><subject>Hemodynamics</subject><subject>Kinetics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Peptides</subject><subject>Plasma levels</subject><subject>Reduction</subject><subject>Vascular Surgery</subject><subject>Ventricle</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxi0EokvhBTggS1y4BGbsOE6OqOJP1Upc6Nny2pNdV1kn2IlWfQceuk63gMShB8vW-Pd9M5qPsbcIHxFAf8oAsoUKBJYDiNXxGdtgg6oSSsvnbAMdQtVKoc_Yq5xvAVB12L1kZ1KVN9Zqw35fhUhzcJmPPbdzCnbgNnq-TTZEHtfKklaATzTNwVPmfkkh7vieDqMv-F0OmdtEPNFuGexMnhelzXl0wc5hjPwY5j33oe8pUZy5s6noHO-X6Nb_0tHtbdxRfs1e9HbI9ObxPmc3X7_8vPheXf_4dnnx-bpysuvmyntqhXa6E1BbYWvdkt5abDR50LVGQN834CxYqQEIa1kLiYo6bEmpbSvP2YeT75TGXwvl2RxCdjQMNtK4ZCMabMuGOikL-v4_9HZcUpl5pTQ0ohGoCiVOlEtjzol6M6VwsOnOIJg1K3PKypSszENW5lhE7x6tl-2B_F_Jn3AKIE9AntaNU_rX-wnbe5VBoTc</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Horio, Takeshi</creator><creator>Ito, Shogo</creator><creator>Fujimoto, Kohei</creator><creator>Izumiya, Yasuhiro</creator><creator>Yoshiyama, Minoru</creator><creator>Iwashima, Yoshio</creator><creator>Nakamura, Satoko</creator><creator>Yoshihara, Fumiki</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20220701</creationdate><title>Kinetics of atrial and brain natriuretic peptides during hemodialysis are regulated in association with different cardiac functional changes</title><author>Horio, Takeshi ; Ito, Shogo ; Fujimoto, Kohei ; Izumiya, Yasuhiro ; Yoshiyama, Minoru ; Iwashima, Yoshio ; Nakamura, Satoko ; Yoshihara, Fumiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-dde827c79204a2a478e7ba167ed0747101df60ca0a3700e14342315e918e55b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical Engineering and Bioengineering</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Blood volume</topic><topic>Brain</topic><topic>Brain natriuretic peptide</topic><topic>Cardiac function</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Correlation</topic><topic>Dialysis</topic><topic>Diameters</topic><topic>Echocardiography</topic><topic>Heart</topic><topic>Hemodialysis</topic><topic>Hemodynamics</topic><topic>Kinetics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Peptides</topic><topic>Plasma levels</topic><topic>Reduction</topic><topic>Vascular Surgery</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horio, Takeshi</creatorcontrib><creatorcontrib>Ito, Shogo</creatorcontrib><creatorcontrib>Fujimoto, Kohei</creatorcontrib><creatorcontrib>Izumiya, Yasuhiro</creatorcontrib><creatorcontrib>Yoshiyama, Minoru</creatorcontrib><creatorcontrib>Iwashima, Yoshio</creatorcontrib><creatorcontrib>Nakamura, Satoko</creatorcontrib><creatorcontrib>Yoshihara, Fumiki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horio, Takeshi</au><au>Ito, Shogo</au><au>Fujimoto, Kohei</au><au>Izumiya, Yasuhiro</au><au>Yoshiyama, Minoru</au><au>Iwashima, Yoshio</au><au>Nakamura, Satoko</au><au>Yoshihara, Fumiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of atrial and brain natriuretic peptides during hemodialysis are regulated in association with different cardiac functional changes</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>37</volume><issue>7</issue><spage>1146</spage><epage>1152</epage><pages>1146-1152</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>The blood levels of atrial and brain natriuretic peptides (ANP and BNP) are both increased markedly in hemodialysis patients, but the kinetics of the two are not always parallel. The present study investigated the association of changes in ANP and BNP levels before and after dialysis with changes in cardiac function in hemodialysis patients. A total of 57 patients (mean age 64 years, 47 males and 10 females) on maintenance hemodialysis with sinus rhythm were enrolled. Blood samples were taken at the beginning and end of dialysis, and plasma levels of ANP and BNP were measured. Changes in cardiac function during dialysis were examined by echocardiography performed just before and after dialysis. Both plasma ANP and BNP concentrations decreased significantly after hemodialysis, but the rate of decrease in BNP [mean ± SD, 555 ± 503 to 519 ± 477 pg/mL (− 6.4%),
P
= 0.011] was much smaller than that in ANP [233 ± 123 to 132 ± 83 pg/mL (− 43.4%),
P
< 0.001]. As for the relation to the changes in echocardiographic parameters before and after dialysis, the decrease in inferior vena cava diameter had a close correlation with the decrease in ANP (
r
= 0.528,
P
< 0.001), but not BNP. In contrast, the decrease in left ventricular end-diastolic volume index was correlated only with the decrease in BNP (
r
= 0.297,
P
= 0.035). The peak velocity ratio of early diastolic to atrial filling decreased with preload reduction by dialysis, and its decrease was more strongly correlated with the decrease in BNP (
r
= 0.407,
P
= 0.002) than that in ANP (
r
= 0.273,
P
= 0.040). These results demonstrated that in hemodialysis patients, the decrease in plasma ANP by a single dialysis was essentially caused by blood volume reduction, while BNP decrease was mainly induced by the reduction of left ventricular overload. Our findings indicate that the kinetics of both peptides during dialysis are regulated by different cardiac and hemodynamic factors.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>35001145</pmid><doi>10.1007/s00380-021-02011-w</doi><tpages>7</tpages></addata></record> |
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| subjects | Biomedical Engineering and Bioengineering Blood Blood levels Blood volume Brain Brain natriuretic peptide Cardiac function Cardiac Surgery Cardiology Correlation Dialysis Diameters Echocardiography Heart Hemodialysis Hemodynamics Kinetics Medicine Medicine & Public Health Original Article Peptides Plasma levels Reduction Vascular Surgery Ventricle |
| title | Kinetics of atrial and brain natriuretic peptides during hemodialysis are regulated in association with different cardiac functional changes |
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