C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

Osteoarthritis (OA), the most prevalent joint disease, is characterized by the progressive loss of articular cartilage. Autophagy, a lysosomal degradation pathway, maintains cellular homeostasis, and autophagic dysfunction in chondrocytes is a hallmark of OA pathogenesis. However, the cause of autop...

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Veröffentlicht in:	The FASEB journal 2022-02, Vol.36 (2), p.e22145-n/a
Hauptverfasser:	Kuwahara, Masanari, Akasaki, Yukio, Kurakazu, Ichiro, Sueishi, Takuya, Toya, Masakazu, Uchida, Taisuke, Tsutsui, Tomoaki, Hirose, Ryota, Tsushima, Hidetoshi, Teramura, Takeshi, Nakashima, Yasuharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals autophagy Autophagy - physiology C10orf10/DEPP Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Death - physiology Cell Survival - physiology chondrocyte Chondrocytes - metabolism Chondrocytes - pathology Female Forkhead Box Protein O3 - metabolism Humans Intracellular Signaling Peptides and Proteins - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged mitochondria Mitochondria - metabolism Mitochondria - pathology osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology
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