Assessing modes of action, measures of tissue dose and human relevance of rodent toxicity endpoints with octamethylcyclotetrasiloxane (D4)

Octamethylcyclotetrasiloxane (D4), a highly lipophilic, volatile compound with low water solubility, is metabolized to lower molecular weight, linear silanols. Toxicity has been documented in several tissues in animals following mixed vapor/aerosol exposures by inhalation at near saturating vapor co...

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Veröffentlicht in:	Toxicology letters 2022-03, Vol.357, p.57-72
1. Verfasser:	Andersen, Melvin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogens - toxicity Cell Proliferation - drug effects Dose metrics Dose-Response Relationship, Drug Human relevance framework Humans Key events Kidney - drug effects Liver - drug effects Lung - drug effects Modes of action Mutagens - toxicity No-Observed-Adverse-Effect Level Octamethyltetracyclosiloxane (D4) Rats Rats, Sprague-Dawley Reproduction - drug effects Risk Assessment Siloxane Siloxanes - pharmacokinetics Siloxanes - toxicity
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