The discovery of potent small molecule cyclic urea activators of STING

STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-02, Vol.229, p.114087-114087, Article 114087
Hauptverfasser:	Basu, Sourav, Middya, Sandip, Banerjee, Monali, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Shrivastava, Ritesh, Surya, Arjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - pharmacology cGAS Cytosol - chemistry DNA - chemistry Haplorhini Humans Immune oncology Immunity, Innate - drug effects Innate immunity Interferon Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred BALB C Neoplasms - drug therapy Protein Binding Signal Transduction Small Molecule Libraries - chemical synthesis Small Molecule Libraries - pharmacology STING Structure-Activity Relationship
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