Development of hot-melt extruded drug/polymer matrices for sustained delivery of meloxicam

For effective resolution of regional subacute inflammation and prevention of biofouling formation, we have developed a polymeric implant that can release meloxicam, a selective cyclooxygenase (COX)-2 inhibitor, in a sustained manner. Meloxicam-loaded polymer matrices were produced by hot-melt extrus...

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Veröffentlicht in:	Journal of controlled release 2022-02, Vol.342, p.189-200
Hauptverfasser:	Chen, Yun-Chu, Moseson, Dana E., Richard, Coralie A., Swinney, Monica R., Horava, Sarena D., Oucherif, Kaoutar Abbou, Cox, Amy L., Hawkins, Eric D., Li, Yongzhe, DeNeve, Daniel F., Lomeo, Joshua, Zhu, Aiden, Lyle, L. Tiffany, Munson, Eric J., Taylor, Lynne S., Park, Kinam, Yeo, Yoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible polymer Hot-melt extrusion Implant Meloxicam Sustained drug delivery
Online-Zugang:	Volltext
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