Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis
Background An increasing number of studies have shown an association between migraine and cardiovascular disease, in particular cardio- and cerebro-vascular events. Methods Three electronic databases (PubMed, Embase and Scopus) were searched from inception to May 22, 2021 for prospective cohort stud...
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| Veröffentlicht in: | Journal of neurology 2022-05, Vol.269 (5), p.2346-2358 |
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| creator | Ng, Chester Yan Hao Tan, Benjamin Y. Q. Teo, Yao Neng Teo, Yao Hao Syn, Nicholas L. X. Leow, Aloysius S. T. Ho, Jamie S. Y. Chan, Mark Y. Wong, Raymond C. C. Chai, Ping Chan, Amanda Chee Yun Sharma, Vijay Kumar Yeo, Leonard L. L. Sia, Ching-Hui Ong, Jonathan J. Y. |
| description | Background
An increasing number of studies have shown an association between migraine and cardiovascular disease, in particular cardio- and cerebro-vascular events.
Methods
Three electronic databases (PubMed, Embase and Scopus) were searched from inception to May 22, 2021 for prospective cohort studies evaluating the risk of myocardial infarction, stroke and cardiovascular mortality in migraine patients. A random effects meta-analysis model was used to summarize the included studies.
Results
A total of 18 prospective cohort studies were included consisting of 370,050 migraine patients and 1,387,539 controls. Migraine was associated with myocardial infarction (hazard ratio, 1.36; 95% CI, 1.23–1.51;
p
= |
| doi_str_mv | 10.1007/s00415-021-10930-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2618227223</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2652732406</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-52ce150be5e513d610f89724cb9e4df9fc52ae266b86fdb20634ed273e3f3a4a3</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0EosvCH-CALHHh0IA_88ENVRQqteoFztbEmaxcEnuxndL8e9zdAlIPnCzN-8zjkV5CXnP2njPWfEiMKa4rJnjFWSdZdfeEbLiSouJKd0_JhknFKi21OiEvUrphjLUleE5OpOq6RrT1hqxXa7AQBwcTdX6EaLML_pSmHMMPpOAHeojDLSS7TBDpHGKGyeWVwhz8js5uF8F5pHvIDn1OHynQtKaMcxlYGvHW4a-DacYMFXiY1uTSS_JshCnhq4d3S76ff_529rW6vP5ycfbpsrKy0bnSwiLXrEeNmsuh5mxsy-3K9h2qYexGqwWgqOu-rcehF6yWCgfRSJSjBAVyS94dvfsYfi6YspldsjhN4DEsyYiat0I0QsiCvn2E3oQllnvvKV2cQhX9logjZWNIKeJo9tHNEFfDmbkvxhyLMaUYcyjG3JWlNw_qpZ9x-Lvyp4kCyCOQSuR3GP_9_R_tbzBPm4o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2652732406</pqid></control><display><type>article</type><title>Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ng, Chester Yan Hao ; Tan, Benjamin Y. Q. ; Teo, Yao Neng ; Teo, Yao Hao ; Syn, Nicholas L. X. ; Leow, Aloysius S. T. ; Ho, Jamie S. Y. ; Chan, Mark Y. ; Wong, Raymond C. C. ; Chai, Ping ; Chan, Amanda Chee Yun ; Sharma, Vijay Kumar ; Yeo, Leonard L. L. ; Sia, Ching-Hui ; Ong, Jonathan J. Y.</creator><creatorcontrib>Ng, Chester Yan Hao ; Tan, Benjamin Y. Q. ; Teo, Yao Neng ; Teo, Yao Hao ; Syn, Nicholas L. X. ; Leow, Aloysius S. T. ; Ho, Jamie S. Y. ; Chan, Mark Y. ; Wong, Raymond C. C. ; Chai, Ping ; Chan, Amanda Chee Yun ; Sharma, Vijay Kumar ; Yeo, Leonard L. L. ; Sia, Ching-Hui ; Ong, Jonathan J. Y.</creatorcontrib><description>Background
An increasing number of studies have shown an association between migraine and cardiovascular disease, in particular cardio- and cerebro-vascular events.
Methods
Three electronic databases (PubMed, Embase and Scopus) were searched from inception to May 22, 2021 for prospective cohort studies evaluating the risk of myocardial infarction, stroke and cardiovascular mortality in migraine patients. A random effects meta-analysis model was used to summarize the included studies.
Results
A total of 18 prospective cohort studies were included consisting of 370,050 migraine patients and 1,387,539 controls. Migraine was associated with myocardial infarction (hazard ratio, 1.36; 95% CI, 1.23–1.51;
p
= < 0.001), unspecified stroke (hazard ratio, 1.30; 95% CI, 1.07–1.60;
p
= 0.01), ischemic stroke (hazard ratio, 1.35; 95% CI, 1.03–1.78;
p
= 0.03) and hemorrhagic stroke (hazard ratio, 1.43; 95% CI, 1.07–1.92;
p
= 0.02). Subgroup analysis of migraine with aura found a further increase in risk of myocardial infarction and both ischemic and hemorrhagic stroke, as well as improved substantial statistical heterogeneity. Migraine with aura was also associated with an increased risk of cardiovascular mortality (hazard ratio, 1.27; 95% CI, 1.14–1.42;
p
= < 0.001).
Conclusion
Migraine, especially migraine with aura, is associated with myocardial infarction and stroke. Migraine with aura increases the risk of overall cardiovascular mortality.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-021-10930-x</identifier><identifier>PMID: 34997286</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiovascular diseases ; Cardiovascular Diseases - complications ; Cerebral infarction ; Headache ; Heart attacks ; Hemorrhage ; Hemorrhagic Stroke ; Humans ; Ischemia ; Medicine ; Medicine & Public Health ; Meta-analysis ; Migraine ; Migraine Disorders - complications ; Migraine with Aura ; Mortality ; Myocardial infarction ; Myocardial Infarction - complications ; Neurology ; Neuroradiology ; Neurosciences ; Prospective Studies ; Review ; Risk Factors ; Stroke ; Stroke - complications</subject><ispartof>Journal of neurology, 2022-05, Vol.269 (5), p.2346-2358</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-52ce150be5e513d610f89724cb9e4df9fc52ae266b86fdb20634ed273e3f3a4a3</citedby><cites>FETCH-LOGICAL-c375t-52ce150be5e513d610f89724cb9e4df9fc52ae266b86fdb20634ed273e3f3a4a3</cites><orcidid>0000-0002-8099-0598 ; 0000-0002-2764-2869</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-021-10930-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-021-10930-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34997286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Chester Yan Hao</creatorcontrib><creatorcontrib>Tan, Benjamin Y. Q.</creatorcontrib><creatorcontrib>Teo, Yao Neng</creatorcontrib><creatorcontrib>Teo, Yao Hao</creatorcontrib><creatorcontrib>Syn, Nicholas L. X.</creatorcontrib><creatorcontrib>Leow, Aloysius S. T.</creatorcontrib><creatorcontrib>Ho, Jamie S. Y.</creatorcontrib><creatorcontrib>Chan, Mark Y.</creatorcontrib><creatorcontrib>Wong, Raymond C. C.</creatorcontrib><creatorcontrib>Chai, Ping</creatorcontrib><creatorcontrib>Chan, Amanda Chee Yun</creatorcontrib><creatorcontrib>Sharma, Vijay Kumar</creatorcontrib><creatorcontrib>Yeo, Leonard L. L.</creatorcontrib><creatorcontrib>Sia, Ching-Hui</creatorcontrib><creatorcontrib>Ong, Jonathan J. Y.</creatorcontrib><title>Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
An increasing number of studies have shown an association between migraine and cardiovascular disease, in particular cardio- and cerebro-vascular events.
Methods
Three electronic databases (PubMed, Embase and Scopus) were searched from inception to May 22, 2021 for prospective cohort studies evaluating the risk of myocardial infarction, stroke and cardiovascular mortality in migraine patients. A random effects meta-analysis model was used to summarize the included studies.
Results
A total of 18 prospective cohort studies were included consisting of 370,050 migraine patients and 1,387,539 controls. Migraine was associated with myocardial infarction (hazard ratio, 1.36; 95% CI, 1.23–1.51;
p
= < 0.001), unspecified stroke (hazard ratio, 1.30; 95% CI, 1.07–1.60;
p
= 0.01), ischemic stroke (hazard ratio, 1.35; 95% CI, 1.03–1.78;
p
= 0.03) and hemorrhagic stroke (hazard ratio, 1.43; 95% CI, 1.07–1.92;
p
= 0.02). Subgroup analysis of migraine with aura found a further increase in risk of myocardial infarction and both ischemic and hemorrhagic stroke, as well as improved substantial statistical heterogeneity. Migraine with aura was also associated with an increased risk of cardiovascular mortality (hazard ratio, 1.27; 95% CI, 1.14–1.42;
p
= < 0.001).
Conclusion
Migraine, especially migraine with aura, is associated with myocardial infarction and stroke. Migraine with aura increases the risk of overall cardiovascular mortality.</description><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cerebral infarction</subject><subject>Headache</subject><subject>Heart attacks</subject><subject>Hemorrhage</subject><subject>Hemorrhagic Stroke</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Migraine</subject><subject>Migraine Disorders - complications</subject><subject>Migraine with Aura</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - complications</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Prospective Studies</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - complications</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1v1DAQhi0EosvCH-CALHHh0IA_88ENVRQqteoFztbEmaxcEnuxndL8e9zdAlIPnCzN-8zjkV5CXnP2njPWfEiMKa4rJnjFWSdZdfeEbLiSouJKd0_JhknFKi21OiEvUrphjLUleE5OpOq6RrT1hqxXa7AQBwcTdX6EaLML_pSmHMMPpOAHeojDLSS7TBDpHGKGyeWVwhz8js5uF8F5pHvIDn1OHynQtKaMcxlYGvHW4a-DacYMFXiY1uTSS_JshCnhq4d3S76ff_529rW6vP5ycfbpsrKy0bnSwiLXrEeNmsuh5mxsy-3K9h2qYexGqwWgqOu-rcehF6yWCgfRSJSjBAVyS94dvfsYfi6YspldsjhN4DEsyYiat0I0QsiCvn2E3oQllnvvKV2cQhX9logjZWNIKeJo9tHNEFfDmbkvxhyLMaUYcyjG3JWlNw_qpZ9x-Lvyp4kCyCOQSuR3GP_9_R_tbzBPm4o</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Ng, Chester Yan Hao</creator><creator>Tan, Benjamin Y. Q.</creator><creator>Teo, Yao Neng</creator><creator>Teo, Yao Hao</creator><creator>Syn, Nicholas L. X.</creator><creator>Leow, Aloysius S. T.</creator><creator>Ho, Jamie S. Y.</creator><creator>Chan, Mark Y.</creator><creator>Wong, Raymond C. C.</creator><creator>Chai, Ping</creator><creator>Chan, Amanda Chee Yun</creator><creator>Sharma, Vijay Kumar</creator><creator>Yeo, Leonard L. L.</creator><creator>Sia, Ching-Hui</creator><creator>Ong, Jonathan J. Y.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8099-0598</orcidid><orcidid>https://orcid.org/0000-0002-2764-2869</orcidid></search><sort><creationdate>20220501</creationdate><title>Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis</title><author>Ng, Chester Yan Hao ; Tan, Benjamin Y. Q. ; Teo, Yao Neng ; Teo, Yao Hao ; Syn, Nicholas L. X. ; Leow, Aloysius S. T. ; Ho, Jamie S. Y. ; Chan, Mark Y. ; Wong, Raymond C. C. ; Chai, Ping ; Chan, Amanda Chee Yun ; Sharma, Vijay Kumar ; Yeo, Leonard L. L. ; Sia, Ching-Hui ; Ong, Jonathan J. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-52ce150be5e513d610f89724cb9e4df9fc52ae266b86fdb20634ed273e3f3a4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cerebral infarction</topic><topic>Headache</topic><topic>Heart attacks</topic><topic>Hemorrhage</topic><topic>Hemorrhagic Stroke</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Migraine</topic><topic>Migraine Disorders - complications</topic><topic>Migraine with Aura</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - complications</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Prospective Studies</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Chester Yan Hao</creatorcontrib><creatorcontrib>Tan, Benjamin Y. Q.</creatorcontrib><creatorcontrib>Teo, Yao Neng</creatorcontrib><creatorcontrib>Teo, Yao Hao</creatorcontrib><creatorcontrib>Syn, Nicholas L. X.</creatorcontrib><creatorcontrib>Leow, Aloysius S. T.</creatorcontrib><creatorcontrib>Ho, Jamie S. Y.</creatorcontrib><creatorcontrib>Chan, Mark Y.</creatorcontrib><creatorcontrib>Wong, Raymond C. C.</creatorcontrib><creatorcontrib>Chai, Ping</creatorcontrib><creatorcontrib>Chan, Amanda Chee Yun</creatorcontrib><creatorcontrib>Sharma, Vijay Kumar</creatorcontrib><creatorcontrib>Yeo, Leonard L. L.</creatorcontrib><creatorcontrib>Sia, Ching-Hui</creatorcontrib><creatorcontrib>Ong, Jonathan J. Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Chester Yan Hao</au><au>Tan, Benjamin Y. Q.</au><au>Teo, Yao Neng</au><au>Teo, Yao Hao</au><au>Syn, Nicholas L. X.</au><au>Leow, Aloysius S. T.</au><au>Ho, Jamie S. Y.</au><au>Chan, Mark Y.</au><au>Wong, Raymond C. C.</au><au>Chai, Ping</au><au>Chan, Amanda Chee Yun</au><au>Sharma, Vijay Kumar</au><au>Yeo, Leonard L. L.</au><au>Sia, Ching-Hui</au><au>Ong, Jonathan J. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>269</volume><issue>5</issue><spage>2346</spage><epage>2358</epage><pages>2346-2358</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background
An increasing number of studies have shown an association between migraine and cardiovascular disease, in particular cardio- and cerebro-vascular events.
Methods
Three electronic databases (PubMed, Embase and Scopus) were searched from inception to May 22, 2021 for prospective cohort studies evaluating the risk of myocardial infarction, stroke and cardiovascular mortality in migraine patients. A random effects meta-analysis model was used to summarize the included studies.
Results
A total of 18 prospective cohort studies were included consisting of 370,050 migraine patients and 1,387,539 controls. Migraine was associated with myocardial infarction (hazard ratio, 1.36; 95% CI, 1.23–1.51;
p
= < 0.001), unspecified stroke (hazard ratio, 1.30; 95% CI, 1.07–1.60;
p
= 0.01), ischemic stroke (hazard ratio, 1.35; 95% CI, 1.03–1.78;
p
= 0.03) and hemorrhagic stroke (hazard ratio, 1.43; 95% CI, 1.07–1.92;
p
= 0.02). Subgroup analysis of migraine with aura found a further increase in risk of myocardial infarction and both ischemic and hemorrhagic stroke, as well as improved substantial statistical heterogeneity. Migraine with aura was also associated with an increased risk of cardiovascular mortality (hazard ratio, 1.27; 95% CI, 1.14–1.42;
p
= < 0.001).
Conclusion
Migraine, especially migraine with aura, is associated with myocardial infarction and stroke. Migraine with aura increases the risk of overall cardiovascular mortality.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34997286</pmid><doi>10.1007/s00415-021-10930-x</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8099-0598</orcidid><orcidid>https://orcid.org/0000-0002-2764-2869</orcidid></addata></record> |
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| ispartof | Journal of neurology, 2022-05, Vol.269 (5), p.2346-2358 |
| issn | 0340-5354 1432-1459 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Cardiovascular diseases Cardiovascular Diseases - complications Cerebral infarction Headache Heart attacks Hemorrhage Hemorrhagic Stroke Humans Ischemia Medicine Medicine & Public Health Meta-analysis Migraine Migraine Disorders - complications Migraine with Aura Mortality Myocardial infarction Myocardial Infarction - complications Neurology Neuroradiology Neurosciences Prospective Studies Review Risk Factors Stroke Stroke - complications |
| title | Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis |
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