Structures and functions of the gut microbial lipidome
Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to eluci...
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| Veröffentlicht in: | Biochimica et biophysica acta. Molecular and cell biology of lipids 2022-03, Vol.1867 (3), p.159110, Article 159110 |
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| container_issue | 3 |
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| container_title | Biochimica et biophysica acta. Molecular and cell biology of lipids |
| container_volume | 1867 |
| creator | Morozumi, Satoshi Ueda, Masahiro Okahashi, Nobuyuki Arita, Makoto |
| description | Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.
•Structural diversity of the gut microbial lipidome•Structure-activity relationship of bacteria lipids to the host receptors•LC-MS/MS-based untargeted lipidomics and data analysis |
| doi_str_mv | 10.1016/j.bbalip.2021.159110 |
| format | Article |
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| identifier | ISSN: 1388-1981 |
| ispartof | Biochimica et biophysica acta. Molecular and cell biology of lipids, 2022-03, Vol.1867 (3), p.159110, Article 159110 |
| issn | 1388-1981 1879-2618 1879-2618 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bacteria - metabolism Bioactive lipids Gastrointestinal Microbiome Humans Lipid Metabolism Lipidomics Lipidomics - methods Lipids - chemistry Microbiome Structure-Activity Relationship |
| title | Structures and functions of the gut microbial lipidome |
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